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Asgeir Theodórs

Publications and source records attributed to Asgeir Theodórs.

4 recordsLinked to original sources
PubMed2006

[The relationship of gastrointestinal symptoms and menstrual cycle phase in young healthy women].

BACKGROUND: Abdominal discomfort is a common complaint by women and may vary with the menstrual cycle. The aim of this study was to investigate abdominal symptoms and general well being of women in relation to different phases of the menstrual cycle as well as gastrointestinal transit time. METHODS: Fourteen young women who were not using any contraceptive medications were recruited. Questionnaire was used to exclude functional gastrointestinal problems. Questionnaires on abdominal symptoms and general well being were used. Gastric emptying time, small intestinal transit time and colonic transit time were measured and serum sex hormone concentrations were measured at three points in the menstrual cycle. RESULTS: Abdominal symptoms were significantly more pronounced at the beginning of the follicular phase. Gastric emptying and colonic transit times were not significantly different between the follicular and the luteal phase of the menstrual cycle. Small bowel transit was faster in the luteal phase (75,7 min) compared with the follicular phase (99,3 min). There was no correlation between the transit times, symptoms or hormone concentrations. CONCLUSIONS: Results indicate that women experience more abdominal symptoms at the beginning of the follicular phase compared to the early luteal phase. Small bowel transit appears to be faster in the luteal phase than in the follicular phase. Further studies on the relationship of gastrointestinal symptoms and the menstrual cycle are needed.

Adult↗
PubMed2004

[The effect of diclofenac on the small intestine studied by wireless endoscopy.].

INTRODUCTION: It is well known that NSAIDs cause erosions and ulcers in the stomach and duodenum but little is known about a possible damage to the small intestine. Direct visualization of the small intestine has not been possible until recently with the introduction of wireless endoscopy. OBJECTIVES OF STUDY: Primary. To assess the effect of diclofenac on the small intestine using wireless endoscopy and measurement of calprotectin in the stools. Secondary. To assess the possible effect of diclofenac on gastro-intestinal symptoms and on the level of hemoglobin. METHODS: Twenty healthy volunteers 21-61 years of age, 10 males and 10 women, received diclofenac 75 mg twice daily for 14 days. Wireless endoscopy was performed before and after diclofenac and also measurements of calprotectin in the stools. The volunteers kept a diary of gastro-intestinal related symptoms during the treatment. In order to eliminate injury and symptoms from the stomach and duodenum, omeprazole 20 mg twice daily was given with the diclofenac. RESULTS: Wireless endoscopy before diclofenac showed no abnormalities in the 20 volunteers. After diclofenac treatment wireless endoscopy showed injuries in 14 volunteers but six had no injury. The number of small intestinal injuries found in each volunteer varied from 2-30. The injuries were equally distributed throughout the small intestine. Two volunteers had an injury in the caecum (ulcer, free blood). Stool calprotectin (normal value <60 mg/L) before diclofenac was 29 mg/L (+/-28) but increased to 148 mg/L (+/-108) (p<0.01) after diclofenac. Fourteen volunteers had gastro-intestinal related symptoms. The mean Hemoglobin concentration decreased from 145.1 to 136.8 g/L (p<0.05) with diclofenac treatment. CONCLUSIONS: The administration of diclofenac is associated with injuries in the small intestine similar as have been described in the stomach and duodenum. The symptoms associated with diclofenac in this study could be related to the small intestinal injury.

English Abstract↗
PubMed2002

[Carcinoma of the colon in Iceland 1955-1989. An investigation of survival according to various pathological parameters.].

OBJECTIVE: The purpose of this study was to estimate various pathological parameters of colon carcinoma over a 35 year time period and evaluate their effect on survival of the patients. MATERIAL AND METHODS: All pathological specimens from patients diagnosed with colon carcinoma in Iceland in the period 1955 to 1989 were re-evaluated in order to determine the following pathological parameters: Tumour size, gross appearance, tissue type, grade, Dukes stage, lymphatic and/or blood vessel invasion, lateral margin involvement, Jass-group of tumour, peritumoural lymphocytic infiltrate, limitation of tumour growth to bowel wall, lymph node metastases, invasive tumour margin and colloid component in adenocarcinoma. Also the following parameters were determined in every case: Age at diagnosis, sex, year of diagnosis and tumour location within the bowel. All these parameters were evaluated with respect to survival of the patients. RESULTS: According to the Icelandic Cancer Registry 1265 patients were diagnosed with colon cancer in Iceland in the period under investigation. After re-evaluation 1205 patients fulfilled the criteria of a primary colon cancer and of those we were able to re-evaluate specimens from 1109 patients to determine histopathological parameters. In a univariable analysis most of the parameters investigated proved significant with respect to survival, except sex, anatomical location of tumour within the bowel, and the proportion of colloid component of tumour. In a multivariable analysis the age at diagnosis proved important as well as the year/period of diagnosis. The following pathological parameters evaluated had a significant prognostic input with regard to survival: Tumour grade, Dukes stage, number of lymph nodes with metastases, peritumoral lymphocytic infiltrate, lateral margin involvement in the surgical specimen and invasive growth pattern of tumour margin. CONCLUSIONS: Many pathological parameters are important in regard with prognostic evaluation of patients diagnosed with colon cancer. We suggest that pathologists should include in their surgical pathology specimen reports of colon cancer, in addition to traditional parameters, an evaluation of peritumoral lymphocytic infiltrate, lateral margin involvement with tumour and the growth pattern of tumour at the invasive margin.

English Abstract↗