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Ashok K Malani

Publications and source records attributed to Ashok K Malani.

16 recordsLinked to original sources
PubMed2007

Pulmonary tumor thrombotic microangiopathy from metastatic gallbladder carcinoma: an unusual cause of severe pulmonary hypertension.

Pulmonary hypertension and cor pulmonale due to tumor emboli causing pulmonary tumor thrombotic microangiopathy (PTTM) is rare and extremely difficult diagnosis to make prior to death. Pulmonary hypertension due to metastatic tumor emboli should be included in the differential diagnosis of various causes of dyspnea in patients with a history of cancer or more common causes, including infection, thromboembolism, metastasis, adverse effects of drugs, and recurrent effusions. We describe a patient with gallbladder carcinoma who presented with progressive dyspnea and severe pulmonary hypertension. The etiology was tumor emboli and PTTM from gallbladder carcinoma, which remained elusive prior to her death despite appropriate clinical investigations and was established on autopsy. To the best of our knowledge, this is likely the second reported case of PTTM from metastatic gallbladder carcinoma.

Carcinoma, Signet Ring Cell↗
PubMed2006

Breast metastasis of ilial carcinoid tumor: case report and literature review.

BACKGROUND: Metastatic breast carcinoids are rare neoplasms. They can be mistaken for primary breast carcinoma both clinically and radiologically, even with known history of carcinoid tumor elsewhere in the body. CASE PRESENTATION: We report a case of unilateral breast metastasis from carcinoid tumor of the small intestine in a 52-year-old woman who was successfully treated by lumpectomy and radiation therapy. An extensive review of the literature reveals only a few cases of metastatic carcinoid to the breast from small intestinal primaries. CONCLUSION: Clinical suspicion for metastasis should be high in a patient with breast mass and history of known carcinoid elsewhere in the body. Lumpectomy alone may be effective in these patients. Mastectomy and especially axillary dissection could be avoided. Their histological appearance may mimic ductal adenocarcinoma of the breast. However, the distinction is important due to differences in management and prognosis.

Journal Article↗
PubMed2006

Pure primary squamous cell carcinoma of the breast: a rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breast.

Pure and primary squamous cell carcinomas of the breast are exceedingly uncommon lesions. To the best of our knowledge, based up on review of the literature, only four studies of patients with these tumors, which presented clinically as breast abscess, have been reported previously. We present a woman who sought medical attention for breast pain and was initially diagnosed with a breast abscess. When she did not respond to antibiotic therapy, an incision as well as drainage was performed. Histologic examination of the material revealed a pure squamous cell carcinoma. An extensive work up ruled out other primary sites. She was treated with mastectomy and radiation therapy and has seen disease-free 3 years postdiagnosis. We also review the literature for presenting features, value of imaging studies, role of cytology in diagnosis, and therapy of such tumors in comparison to the usual ductal carcinomas of the breast.

Adult↗
PubMedDate not supplied

Palmar skin lesions reversed by propylthiouracil therapy.

Antithyroid thioureylene compounds such as propylthiouracil, methimazole, and thiamazole have been shown to have some beneficial effect in the treatment of plaque psoriasis in small clinical trials. An incidental finding is reported here on a patient with autoimmune polyendocrine syndrome type II who had dermatitis-like palmar skin lesions on the right palm, which was reversed with propylthiouracil therapy.

Adult↗