Biomedical subjects

Ashwin Sivakumar

Publications and source records attributed to Ashwin Sivakumar.

3 recordsLinked to original sources

PubMed2006

From sequences to a functional unit.

Functional insights at the gene product level would help the drug discovery industry to effectively tap targets for therapeutics and biomedical applications. A complete functional unit can be multidomain, and it is the co-occurrence and interaction of these multiple domains that determine the function and functional diversity of their gene products. With at least 10% of genes from complete genomes existing in fused form, identifying gene fusion events helps us categorize the protein universe into distinct functional units with only sequence information.

Animals↗

PubMed2005

ADDA: a domain database with global coverage of the protein universe.

We used the Automatic Domain Decomposition Algorithm (ADDA) to generate a database of protein domain families with complete coverage of all protein sequences. Sequences are split into domains and domains are grouped into protein domain families in a completely automated process. The current database contains domains for more than 1.5 million sequences in more than 40,000 domain families. In particular, there are 3828 novel domain families that do not overlap with the curated domain databases Pfam, SCOP and InterPro. The data are freely available for downloading and querying via a web interface (http://ekhidna.biocenter.helsinki.fi:9801/sqgraph/pairsdb).

Algorithms↗

PubMed2002

2D gels and bioinformatics--an eye to the future.

2-D Gel Technology has had profound impact on proteomic research over the years. Informatics support brought a new dimension to 2D gels and associated technologies. But with advent of new and emerging technologies, it will be interesting to observe the trends of 2D gel technology in the years to come. Here we review 2D gel technology and its applications besides looking at the future scope of 2D gels in the post genome era.

Computational Biology↗