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Biomedical subjects

Atilla Iyisoy

Publications and source records attributed to Atilla Iyisoy.

At least 19 recordsLinked to original sources
PubMed2006

Safety of gadodiamide mixed with a small quantity of iohexol in patients with impaired renal function undergoing coronary angiography.

Gadolinium-based contrast agents can be used in diagnostic and interventional angiography, and are safe in recommended doses in patients with impaired renal function, but the image quality is usually unsatisfactory. The objective of the present study is to evaluate the safety of gadolinium mixed with a small quantity of iodine-based contrast agent and the image quality of this mixture in patients with renal insufficiency undergoing diagnostic coronary angiography. Forty-two patients with baseline creatinine level>1.5 mg/dl were randomized into gadolinium or iodine groups. In the gadolinium group gadodiamide was mixed with 1:3 iohexole and in the iodine group only this agent was used as contrast material. Peak creatinine levels 48-72 h after the procedure were measured. The primary end point was the development of contrast-induced nephropathy (CIN), defined as >25% increase of baseline creatinine levels, and the secondary end points were absolute and relative changes in baseline creatinine levels. Total contrast volumes used were not different between groups (57+/-11 ml in gadolinium and 55+/-10 ml in iodine; P=0.68). Mean creatinine level did not increase significantly in the gadolinium group (from 1.9+/-0.3 to 1.9+/-0.4 mg/dl; P=0.06), but did in the iodine group (from 2.0+/-0.4 to 2.3+/-0.5 mg/dl; P=0.001). No patient had CIN in the gadolinium group whereas 5 (23%) patients had this phenomenon in the iodine group (P=0.048). Contrast regimen was very well tolerated in the gadolinium group, with only transient headache in two patients. Gadodiamide mixed with a small quantity of iohexol is safe in patients with azotemia undergoing diagnostic coronary angiography. The image qualities obtained with this combination are also satisfactory in all of the cases. Further evaluation of the safety of this technique is warranted, especially in other types of diagnostic and interventional procedures in which a higher amount of contrast dye is needed.

Aged↗
PubMed2006

Chitosan-coated alginate microspheres for embolization and/or chemoembolization: in vivo studies.

In this study, chitosan-coated alginate microspheres were prepared by the ionic complexation of alginate and chitosan biopolymers to use in embolization and/or chemoembolization studies. Biopolymeric microspheres were prepared by the ionic gelation technique of alginate with a suitable divalent cation (i.e. CaCl2) in a suspension medium composed of mineral oil and petroleum ether including emulsifier (i.e. Tween-80) and then obtained microspheres were coated with chitosan in an aqueous chitosan solution while the medium was magnetically stirred. The obtained microspheres are in the size range of 100-400 microm and they can be prepared as required by changing the preparation conditions (i.e. stirring rate, concentration of biopolymers, molecular weight and concentration of chitosan, etc.). In the in vivo studies, New Zealand rabbits were used as the test animals. Both complete and partial embolization of the kidney were achieved by using the microspheres. The renal angiograms obtained before/after embolization and the histopathological observations showed the feasibility of the chitosan-coated alginate microspheres as an alternative embolization and/or chemoembolization agent.

Alginates↗
PubMed2006

[The effect of paclitaxel-eluting stents on restenosis].

OBJECTIVE: In our study we aimed to investigate the effects of paclitaxel-eluting stent on restenosis. METHODS: Sixteen porcine were randomly assigned to two groups (n=8 per group): control group animals received conventional stent implantation and study group animals -paclitaxel-eluting stent implantation. Both groups were treated with 300 mg acetylsalicylic acid and 75 mg clopidogrel daily. The degree of neointimal proliferation and effect of drug-eluting stent on restenosis were evaluated 6 weeks after by angiography and intravascular ultrasound (IVUS). RESULTS: Angiographic in-stent restenosis was lower in paclitaxel-eluting stent group (12.50 +/- 7.07% versus 41.25 +/- 28.50%, p=0.001). The IVUS data demonstrated that paclitaxel group animals had larger minimal lumen area (8.76 +/- 1.09 mm2 versus 6.23 +/- 3.10 mm2, p=0.028), smaller mean neointimal proliferation area (1.03 +/- 0.75 mm2 versus 3.55 +/- 2.86 mm2, p=0.01) and mean percent stenosis (10.71 +/- 8.10% versus 36.85 +/- 30.93%, p=0.01). CONCLUSION: This study suggests that drug-eluting stents may also have a preventive effect for the in-stent restenosis.

Animals↗
PubMed2005

Effect of octreotide in the prevention of doxorubicin cardiotoxicity.

OBJECTIVE: A precise method for prevention from doxorubicin cardiotoxicity is not known. We examined whether octreotide has a protective effect against doxorubicin cardiotoxicity. METHODS: New Zealand rabbits (n=44) were divided into 4 groups according to drugs given: Group A (n=12) doxorubicin and octreotide, Group B (n=12) only doxorubicin, Group C (n=10) only octreotide and Group D (n=10) only saline. Effects of the drugs were evaluated in terms of histopathological score, fractional shortening (FS) and prolongation of the QTc interval. RESULTS: Mean pathological score for cardiotoxicity (Group A: 3.7+/-0.5, Group B: 3.9+/-0.3), prolongation of QTc (Group A: from 244.5+/-21.2 ms to 282.9+/-25.9 ms, p<0.0001; Group B: from 248.5+/-17.7 ms to 298.3+/-13.7 ms, p<0.00001) and the rate of decrease in FS (Group A: from 34.4+/-2.0 to 28.0+/-2.0, p<0.05; Group B: from 35.1+/-1.9 to 24.8+/-1.3, p<0.05) were higher in Group B when compared to Group A, but only difference in the rate of decrease in FS was statistically significant (p<0.001). None of these variables changed significantly in groups C and D. CONCLUSION: In this preliminary study, octreotide seems not to reduce doxorubicin cardiotoxicity. On the other hand, a consistent tendency of decreased cardiotoxicity in octreotide+doxorubicin group was observed, although only the difference in FS decrease was significant. Further investigations are needed to address the issue of the extent and the mechanisms of this effect.

Animals↗
PubMed2004

Single coronary artery with anomalous origin of the right coronary artery from the left anterior descending artery with a unique proximal course.

A 62-year-old man with hypertension and hypercholesterolemia was referred to our unit for evaluation of chest pain. A very rare variant of single coronary artery, in which the anomalous right coronary artery originated as a separate branch from the left anterior descending artery, was incidentally found on his coronary angiography. The anomalous right coronary artery in our case appears to be unique in that it courses intraseptally rather than rightwards proximally and has obstructive atherosclerotic lesions resulting in inferior ischemia. Moreover, the acute angle made by the anomalous right coronary artery to turn toward the atrioventricular groove may have reduced the flow velocity and contributed to the development of inferior ischemia.

Coronary Angiography↗
PubMed2004

Angiographic restenosis after myocardial bridge stenting.

Data on restenosis after stent implantation in myocardial bridges (MB) are very limited. Six-month angiographic results for 12 symptomatic patients who underwent stent implantation for myocardial bridges were compared retrospectively with those of 39 patients who underwent direct stent implantation for de novo atherosclerotic lesions in the left anterior descending artery. Diameter stenosis decreased from 69 +/- 8% to 4 +/- 5% in the MB group and from 79 +/- 8% to 7 +/- 6% in the control group after stent deployment. Systolic narrowing was abolished in all patients with MB. In follow-up, quantitative angiography revealed late loss of 1.8 +/- 1.3 mm in the MB group and 0.9 +/- 0.9 mm in the control group (P = 0.025). The in-stent restenosis rate was also higher in the MB group compared to the control group (67% versus 28%; P = 0.037). Despite favorable immediate results, stent implantation in MBs may not be promising because of the higher in-stent restenosis rate compared to stenting in de novo atherosclerotic lesions.

Angioplasty, Balloon, Coronary↗
PubMed2004

Intercoronary communication with unidirectional blood flow.

Intercoronary communication is a rare condition in which there is an open-ended circulation with bidirectional blood flow between two coronary arteries. This report highlights a case of an intercoronary connection between the right coronary and circumflex arteries with unidirectional flow. Selective injection of the right coronary artery showed retrograde filling only of the circumflex artery, but left coronary injection did not fill the right coronary artery.

Chest Pain↗
PubMed2003

Relationship between noninvasive reperfusion criteria and pulsed-wave tissue Doppler parameters in patients with acute myocardial infarction receiving thrombolytic therapy.

Several studies have proven that noninvasive reperfusion criteria (NRC) have prognostic significance in patients receiving thrombolytic therapy (TT) after acute myocardial infarction (acute MI). In this study, we investigated the relationship between NRC and pulsed tissue Doppler (PTD) parameters in patients receiving TT after acute MI, and the role of PTD in the management and follow-up of patients with acute MI. The study group(n= 41)was divided into four subgroups defined as: anterior and posterior MI, with or without NRC. In the first PTD measurements (2-3 days after acute MI), all acute MI patients had significantly smaller peak systolic (S-wave) velocity in all evaluated segments and longer Q-Speak durations (time elapsed from the inscription of the Q-wave on the surface ECG to the peak of the S-wave in PTD) as compared with control patients(n= 22; P < 0.001 for both). Among the diastolic parameters, the E/A ratio was significantly smaller in the study group compared with the control group(P < 0.001). Among the patients who had received TT in the first 2 hours, those patients who had NRC displayed significantly higher peak S-wave values in all evaluated segments than those without NRC(P < 0.05). The second PTD study (4-5 weeks after acute MI), revealed that the difference between the systolic PTD parameters of the noninfarcted regions of the study and control groups disappeared. Infarct-related segments, however, displayed significant improvement only in patients having NRC. There was a significant positive correlation between the mean mitral annular S-wave velocity and left ventricular ejection fraction(r = 0.59, P < 0.001). In conclusion, a significant relationship was observed between the PTD parameters and the NRC, which are known to have prognostic significance.

Case-Control Studies↗
PubMed2003

Seasonal variability of QT dispersion in healthy young males.

BACKGROUND: There are few data related to the seasonal influences on the QT dispersion. METHODS: We analyzed the effects of seasons on QT dispersion in a large group of healthy young males. We studied the seasonal variability of QT dispersion in 523 healthy male subjects aged 22 +/- 4 years (ranging from 20 to 26). Four seasonal 12-lead resting electrocardiograms (ECGs) recorded at double amplitude were performed at 25 mm/s at intervals of 3 months. Subsequent ECGs were recorded within 1 hour of the reference winter recording. QT dispersion was defined as the difference between the longest and the shortest mean QT intervals. RESULTS: There was a significant seasonal variation in QT dispersion (P = 0.001), with the largest QT dispersion in winter (71 +/- 18 ms) and the smallest one in spring (43 +/- 19). CONCLUSION: There exists a significant seasonal variation in QT dispersion of healthy subjects and such variability should be taken into consideration in the evaluation process of QT dispersion.

Adult↗
PubMed2002

Seasonal variation of P-wave dispersion in healthy subjects.

We studied the seasonal variability of P dispersion in 523 healthy male patients, aged 22 +/- 4 years (range, 20-26). Four seasonal 12-lead resting electrocardiograms were recorded at 2 mV/cm standardization and at 50 mm/s paper speed at intervals of three months. Electrocardiograms were recorded between the hours 10 to 12 AM. The difference between the maximum P-wave duration and minimum P-wave duration was calculated and defined as "P dispersion." There was a significant seasonal variation in the maximum P-wave duration (P = .001) and P dispersion (P = .001), with the longest maximum P-wave duration (121 +/- 16 ms) and P dispersion (41 +/- 7 ms) observed in winter and the shortest maximum P-wave duration (106 +/- 15 ms) and P dispersion (24 +/- 8 ms) observed in summer. The minimum P-wave duration did not show any significant seasonal variation. In conclusion, there exists a significant seasonal variation in the maximum P-wave duration and P dispersion in healthy patients. Seasonal variation of P dispersion resulted from the significant variation of maximum P-wave duration.

Adult↗
PubMed2002

Idiopathic ventricular fibrillation in a patient with Wolff-Parkinson-White syndrome.

Ventricular fibrillation in a patient with ventricular preexcitation is usually due to atrial fibrillation with an extremely rapid ventricular rate from which it degenerates. We present a case with Wolff-Parkinson-White syndrome and coexistent idiopathic ventricular fibrillation. The patient, a 23-year-old male, had had a cardiac arrest four years earlier. In electrophysiological study, the accessory pathway was located in the left posteroseptal region and successfully eliminated with radiofrequency catheter ablation. After the ablation procedure, ventricular fibrillation was induced with programmed ventricular stimulation. A dual chamber implantable cardioverter defibrillator was implanted in the patient.

Adult↗
PubMedDate not supplied

Radiofrequency catheter ablation of a left lateral accessory pathway in a patient with persistent left superior vena cava.

Persistent left superior vena cava is an unusual congenital anomaly that can coexist with accessory atrioventricular pathways. This anomaly can cause difficulty in mapping because of the dilated coronary sinus. This study describes a successful catheter ablation in a young male with persistent left superior vena cava and Wolff-Parkinson-White Syndrome as a result of a left lateral accessory pathway.

Accessory Nerve↗