Biomedical subjects

Atsuomi Shundo

Publications and source records attributed to Atsuomi Shundo.

3 recordsLinked to original sources

PubMed2006

Enhancement of molecular-shape selectivity in high-performance liquid chromatography through multi-anchoring of comb-shaped polymer on silica.

Poly(octadecylacrylate) having plural trimethoxysilyl groups in the side chain (co-ODA(n)) was newly synthesized and immobilized onto silica through these groups. The liquid chromatographic behavior of silica-supported co-ODA(n) (Sil-co-ODA(n)) was investigated and compared with that of Sil-ODA(n), in which poly(octadecylacrylate) was immobilized through a terminal trimethoxy group at one side of the polymer main chain. Sil-co-ODA(n) showed higher selectivity for molecular shape, especially molecular planarity of PAHs than Sil-ODA(n).

Acrylates↗

PubMed2005

Molecular-length and chiral discriminations by beta-structural poly(L-alanine) on silica.

Poly(L-alanine)-grafted porous silica (Sil-Ala22) was prepared by polymerization of N-carboxyanhydride of L-alanine initiated by 3-aminopropylated silica. Its selective interaction with aromatic guest molecules was evaluated by the retention time in liquid chromatography using the column packed with Sil-Ala22. Sil-Ala22 showed a specific selective retention with discriminating molecular shapes, such as molecular length, linearity and planarity. This selectivity can be explained by a multiple pi-pi interaction with the carbonyl groups one dimensionally-aligned on the rigid beta-form structure in the peptide main chain. Chiral separation with Sil-Ala22 was also described.

Chromatography, Liquid↗

PubMed2004

Conformational effect of silica-supported poly(octadecyl acrylate) on molecular-shape selectivity of polycyclic aromatic hydrocarbons in RP-HPLC.

Poly(octadecyl acrylate) with a terminal reactive group was synthesized by radical telomerization in various solvents. The polymers were grafted onto porous silica for use in RP-HPLC, and the molecular recognition ability was investigated along with the selectivity for the structural isomers of polycyclic aromatic hydrocarbons. The mechanism of selectivity was also investigated with differential scanning calorimetry and NMR spectroscopic observations.

Journal Article↗