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Biomedical subjects

Aysenur Cila

Publications and source records attributed to Aysenur Cila.

10 recordsLinked to original sources

Biochemical markers of bone turnover in diagnosis of myeloma bone disease.

This study was designed to explore the value of markers of bone turnover, macrophage inflammatory protein-1alpha (MIP-1alpha), and osteopontin (OPN) in the diagnosis of myeloma bone disease. Twenty-five patients with newly diagnosed and untreated multiple myeloma (MM), and 22 age-, sex-, and bone mineral density-matched control subjects were enrolled. Levels of MIP-1alpha, OPN, carboxy-terminal telopeptide of Type-1 collagen (C-telopeptide or Ctx), deoxypyridinoline (DPD), Type-1 collagen propeptide (T1Pro), and bone-specific alkaline phosphatase (BALP) were assessed in both groups. Twenty-two of the patients had bone involvement documented by skeletal surveys and lumbar spinal magnetic resonance imaging. Levels of serum Ctx, OPN, MIP-1alpha, and urine DPD were significantly higher in MM patients with bone disease than in controls (P<0.01). Serum Ctx levels were elevated in 90.9% of patients with MM and 40.9% of controls (P<0.001). Urine DPD levels were elevated in 90.4% of the patients and 31.8% of the controls (P<0.001). The serum OPN and MIP-1alpha levels of the patients were significantly correlated with beta2-microglobulin and lactate dehydrogenase levels (P<0.05). Our study indicates that Ctx and DPD are sensitive markers of bone disease in MM, and higher than normal values suggest presence of bone disease rather than benign osteoporosis in MM. The utility of OPN and MIP-1alpha needs to be further investigated.

Aged↗

Congenital cerebellar primitive neuroectodermal tumor in a newborn.

Neonatal primitive neuroectodermal tumor is a rare clinical entity. The initial presentation in affected newborns is often subtle, nonspecific, and rarely includes neurological signs. Here we report a newborn with congenital cerebellar primitive neuroectodermal tumor. We had detected hydrocephalus and enlarged biparietal diameter at the 36th week of gestational age by fetal ultrasonography.

Cerebellar Neoplasms↗

Quantitative thallium-201 scintigraphy in childhood osteosarcoma: Comparison with technetuim-99m MDP and magnetic resonance imaging in the evaluation of chemotherapeutic response.

The aim of this study was to assess early (15 min) and late 2 h) thallium-201 (201Tl) uptake in children with osteosarcoma and to compare these findings with magnetic resonance imaging (MRI) and technetium-99m methylenediphosphonate (99mTc MDP), with emphasis on evaluating tumor viability before and after chemotherapy. Fifteen patients with biopsy-proven osteosarcoma received standard preoperative chemotherapy with a combination of cisplatin, Adriamycin, and high-dose methotrexate. Their ages ranged between 7 and 18 years (median 14.5 years). All patients had 201Tl, 99mTc MDP, and MRI studies. Thallium scintigraphy was performed at 15 min and 2 h after IV injection of 92 MBq of thallium. Thallium uptake ratio was calculated by dividing the count density of the lesion (L) by that of the controlateral normal (N) area. The percent reduction of 201Tl uptake ratio (alteration ratio) was calculated by [100x(prechemotherapy L/N-postchemotherapy L/N)/prechemotherapy L/N]. Pathologic changes were graded on the basis of % tumor necrosis as defined histologically. Scintigraphic comparisons demonstrated a high-degree of correlation with late 201Tl alteration ration and poor correlation with both early 201Tl and 99mTc MDP alteration ratios. Late 201Tl images were superior to early 201Tl, 99mTc MDP, and MRI in predicting tumor response to chemotherapy as determined by % tumor necrosis (p<.01). The authors found that late 201Tl was an accurate test for evaluating the response to specific therapeutic regimens and it can be useful planning surgery or choosing alternative chemotherapeutic regimens.

Adolescent↗

Course of nonsurgical management of burst fractures with intact posterior ligamentous complex: an MRI study.

STUDY DESIGN: Prospective study. OBJECTIVES: To evaluate the results of nonsurgical management of burst fractures with intact posterior ligamentous complex and to investigate the effect of trauma and/or residual kyphotic deformity on adjacent and next adjacent (neighboring) discs. SUMMARY OF BACKGROUND DATA: Conservative treatment based on integrity of posterior ligamentous complex is controversial, probably because of poor evaluation by clinical and indirect radiographic findings. Degenerative changes in the adjacent discs due to trauma and/or residual kyphotic deformity is a common expectation. MATERIAL AND METHODS: Fifteen consecutive patients who were intact neurologically with burst fractures (T11-L2) were treated nonsurgically with the indication based solely on the integrity of posterior ligamentous complex determined by MRI. Correction of deformity and stabilization with a total body cast under sedation were the mainstays of treatment. Patients were mobilized the next day, and casts were removed at the end of the third month follow-up period with no further external stabilization. Local kyphosis angle, sagittal index, and percent of compression of anterior body height were measured on pretreatment, post-treatment, third month, and latest follow-up radiographs. All of the preoperative and latest follow-up MRI studies of the patients were obtained to examine the discs adjacent and next adjacent to the fractured levels. The self-reported perceptions of the patients of function, pain and appearance were analyzed using the Likert Questionnaire. RESULTS: There were eight female and seven male patients with an average age of 28 (range, 15-49) years. Average follow-up period was 31 (range, 24-51) months. Average local kyphosis angle was found to be 16.5 degrees (0-34 degrees ) after trauma. It was corrected to 5 degrees (range, 19-25 degrees ) and deteriorated to 14.6 degrees (range, 2-25 degrees ) at the third month and to 17 degrees (range, 2-29 degrees ) at the final follow-up review. There was a similar tendency for both sagittal index and percent anterior body height. The pretreatment MRI analysis revealed changes in the shape of the discs (narrowing or herniation into the body) with no change in the signal intensity of nucleus pulposus in eight of the cranial and four of the caudal adjacent discs. On follow-up MRI, there was only one intact disc with a normal shape cranially. All others had height loss, but only one had complete loss of signal intensity. Caudally, two additional discs had changes in shape without any gross changes in signal intensity of nucleus pulposus, whereas two had changes in signal intensity without change in shape. Only two of the next adjacent discs had changes in shape or signal intensity at the time of injury or at latest follow-up review. Average score of function, pain, and appearance were 3.9 (range, 3-5), 3.7 (range, 2-5), and 3.7 (range, 2-5), respectively, at the latest follow-up review. All patients were back at work in 3.6 (range, 1-9) months on average and all were satisfied with their treatment. CONCLUSIONS: The present study revealed that an intact posterior ligamentous complex might not prevent loss of correction gained by nonsurgical management of burst fractures. Significant loss occurs in the first 3 months despite external stabilization. However, the magnitude of residual deformity usually remains close to the initial deformity. Although changes in the shape of adjacent discs occur due to trauma and/or natural course, significant loss in signal intensity of nucleus pulposus is unlikely. Patient outcome seems to be highly satisfactory despite residual deformity.

Adolescent↗

Diastematomyelia: a case with familial aggregation of neural tube defects.

Intrauterine neural tube defects, meningomyelocele, and diastematomyelia are developmental errors at different stages of the closure of the neural tube. The familial aggregation of these neural tube defects is not previously reported in the literature and should make one think about a common embryogenesis and a possible common mechanism of etiopathogenesis leading to anomalies at different stages of this embryogenesis. This paper presents a 12-year-old Turkish boy with diastematomyelia who was suspected with a demonstrative dermatologic finding without any neurologic sign and diagnosed with magnetic resonance imaging (MRI). He has a positive family history of a stillbirth with neural tube defect, an exitus with meningomyelocele, and an epileptic child in his female siblings.

Adult↗

Diffuse spinal and intercostal nerve involvement in chronic inflammatory demyelinating polyradiculoneuropathy: MRI findings.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an uncommon demyelinating disorder with a relapsing and remitting or continuously progressive course. Hypertrophic nerve roots, sometimes associated with gadolinium enhancement, has been reported more commonly in lumbar spine and less commonly in the brachial plexus and cervical roots; however, diffuse involvement of intercostal nerves bilaterally has never been reported previously. We present MRI findings which include diffuse enlargement and mild enhancement of roots and extraforaminal segments of nerves in all segments except a short segment between T12-L2 as well as all the intercostal nerves in a case of CIPD with a 10-year history.

Biopsy, Needle↗

Angiographically occult epidural arteriovenous fistula of the craniocervical junction.

BACKGROUND: Spinal dural and intradural arteriovenous fistulas (AVFs) have been the subject of numerous reports but purely epidural AVFs causing venous congestion within the spinal cord are rare. CASE DESCRIPTION: We describe a patient with an exclusively epidural arteriovenous fistula and congestive myelopathy. There are three interesting features of this case as described below: 1) The presence of a purely epidural AVF of the cranio-cervical junction. According to our knowledge this is the first case of an AVF in this location. 2) The lesion was angiographically occult. This was probably because of the extremely slow flow of the fistula. 3) Despite the negative angiograms, exploratory surgery was conducted because of positive clinical and MR findings. CONCLUSIONS: Epidural AVF/AVM of the foramen magnum should be considered in the differential diagnosis in patients with chronic myelopathy, even if cranial and spinal angiograms are negative. In these cases, we recommend that if clinical and radiological investigations strongly suggest the presence of an arteriovenous fistula, surgical exploration should be performed.

Adult↗

Multifocal fibrosclerosis: a new case report and review of the literature.

A case of multifocal fibrosclerosis is presented with MR images. Bilateral sclerosing orbital pseudotumor invading cavernous sinuses were the presenting disorder. Magnetic resonance imaging showed involvement of paranasal sinuses bilaterally and multiple supratentorial dural masses. Retroperitoneal fibrosis was associated with the condition. Multifocal involvement should be considered in patients with sclerosing orbital pseudotumor and an imaging approach should be performed on the appropriate clinical condition to document possible coexistence of other disorders including retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, and Riedel's thyroiditis

Adult↗

Reliability and necessity of dynamic computerized tomography in diagnosis of atlantoaxial rotatory subluxation.

Dynamic computerized tomography (DCT) has been accepted to be the standard diagnostic method of atlantoaxial rotatory subluxation (AARS) although its reliability and reproducibility has not been shown yet. The purpose of this study was to evaluate the intraobserver reproducibility and interobserver reliability of DCT. Standard DCT scans of 18 patients with acute torticollis and 12 normal subjects were examined two times in between a time interval of 1 month by three specialists and a last-year resident to define any existing AARS. The interobserver reliability kappa coefficient was -0.015 (poor) for the first examination and 0.327(fair) for the second one. The intraobserver reproducibility kappa coefficients were 0.135 (slight), -0.204 (poor), 1.00 (almost perfect), and 0.474 (moderate) respectively. It was found that DCT has a poor reliability and reproducibility in diagnosing AARS in patients with acute torticollis. Therefore, its routine use is not cost effective in patients with acute torticollis where the deformity usually resolves by a simple cervical mobilization.

Acute Disease↗