PubMed Health⌕ Search

Biomedical subjects

B A Alaev

Publications and source records attributed to B A Alaev.

12 recordsLinked to original sources
PubMed1992

[Ethnic factors and their relation to the pathogenesis and geography of multiple sclerosis].

Epidemiological and immunogenetic studies made in patients with multiple sclerosis (MS), carried out for the first time in Uzbekistan, demonstrated the varying disease incidence in 4 populations: Uzbek, Tadjik, Russian and Tatar. In Uzbeks and Russians, a significant relationship was established between MS and antigen HLA-B7 carriership. A correlation was noted between the low incidence of MS among Uzbeks (0.8:100,000) and the higher among Russians (11.5:100,000) and the low prevalence of antigen HLA-B7 in the Uzbek and the higher one in the Russian population. It has been shown that the use of the medico-geographic mapping to specify the nature of MS is ineffective without regard to ethnic factors.

Asian People↗
PubMed1991

[The characteristics of the prevalence of vertebrogenic lumbosacral radiculalgias among cotton and tobacco growers in Uzbekistan].

An epidemiological study of the prevalence of vertebrogenic lumbosacral radiculalgias (VLSR) was made among 910 cotton growers and 311 tobacco growers of Samarkand Province of Uzbekistan. Out of the 1221 persons aged 18 to 70, VLSR were revealed in 223. The incidence of the disease among cotton growers was 6.3 and among tobacco growers, it amounted to 7.1 per 100 workers. A definite correlation was established between the disease and the character of work and specificity of the working postures: a long stay in a bent position aggravated by the pressure of the apron strap weighing 8-10 kg on the lumbar part of the spine. A correlation was also established between the incidence of VLSR and the length of service.

Age Factors↗
PubMed1990

[Climatic factors and clinical polymorphism of multiple sclerosis].

A study was made of the clinical manifestations of multiple sclerosis (MS) in 106 Russians born in the European part of the USSR, who moved afterwards to Uzbekistan at different times. Analysis of the two patients' groups demonstrated that in those who fell ill in Uzbekistan, MS started at an older age and ran a more malignant course as compared to those who had fallen ill in the European part of the USSR. Therefore, a model has been tried, permitting one to assess the influence of the climatogeographic conditions of the region under study on the clinical polymorphism of MS after exclusion of the populational differences between the examinees.

Adolescent↗
PubMed1987

[Familial cases of multiple sclerosis when siblings reside in different climato-geographical zones].

A clinical study covered 11 patients with multiple sclerosis (MS) from 5 families (4 Russian and 1 Tatar family) born outside the Central Asia and then living for a long time in different climatogeographic regions of the USSR belonging to zones with varying risk of the disease: the probands have stayed in Uzbekistan while their ill siblings live in the Far East, Volga region, Urals, Tajikistan, and Kazakhstan. The ill siblings of each family irrespective of the place they live in have displayed the similarity of their age at the onset of MS, as well as the similarity of the clinical picture and the course of the process which suggests the involvement of genetic factors in the etiology of familial forms of the disease.

Adolescent↗
PubMed1985

[Demyelinating encephalomyelitis in child native to Uzbekistan].

Demyelinizing encephalomyelitis is described in a 7-year-old Uzbek girl. The clinical picture and a wave-like course of the disease were similar to the corresponding findings observed in children with multiple sclerosis who live in the European part of the USSR although both the patient and her parents are indigenous inhabitants of Uzbekistan and have never travelled beyond the borders of the republic.

Child↗
PubMed1985

[Clinical picture and course of multiple sclerosis among inhabitants of the southwest regions of Uzbekistan].

Eighty-two typical cases of disseminated sclerosis (DS) in the population of several regions of Uzbekistan were analyzed. Three groups of patients were identified: group I included indigenous population (21); group II non-indigenous population born in Uzbekistan (14); group III non-indigenous population born in the European part of the country. The clinical study allowed the authors to elucidate the presence of similar signs indicating the unity of etiopathogenetic factors of DS and differences occasioned by the populational characteristics of various ethnic groups of the total population as well as by the influence of the climatic and geographical conditions of the region.

Adult↗
PubMed1983

[Demyelinating diseases in the southern regions of Uzbekistan].

Examination of the clinical archives for 1931-1980, epidemiological survey of the Samarkand and Kashka-Darya regions as well as clinical examination of 49 patients showed disseminated sclerosis to occur more rarely among the aboriginal population (26,8%) than among newcomers (73,2%). General morbidity was 1.7: 100.000 population; this made it possible to attribute the region under study to a low risk zone. The debut, clinical picture and clinical course of disseminated sclerosis in three groups of patients (aboriginal population, persons born in other Uzbekistan regions and newcomers) were similar and did not differ from classical descriptions by European authors.

Demyelinating Diseases↗
PubMed1983

[Clinical polymorphism in a familial case of demyelinating disease].

A family of non-indigenous inhabitants of Uzbekistan whose three generations have produced three cases of demyelinizing disease are described. One female patient was born, while the other two have been living in the South of Uzbekistan for a long period of time. Multiple lesions of the nervous system, spontaneous and drug-induced remissions in the course of the disease constituted a clinical picture similar to that seen in disseminated sclerosis. The polymorphism of the neurologic signs combined with affections of different endocrine organs in each patient showed a predisposing role of the genetic mechanism in a possible impact of damaging exogenous factors.

Adult↗
PubMed1983

[Various regional features of the clinical picture and epidemiology of amyotrophic lateral sclerosis].

An analysis of the incidence of lateral amyotrophic sclerosis (LAS) in the Samarkand region was carried out on the basis of the archive materials collected by a nervous disease clinic over 50 years (1931-1980). A total of 70 patients had been treated, with a tendency toward an increase in the number of such patients over the last two decades. There was a prevalence of patients from the indigenous population (51) in comparison with the non-indigenous one (19). People over 45 years of age contracted LAS more frequently (38 out of 70). The results of the author's own clinical observation of 23 patients are presented (1971-1980). The cervical-thoracic form of LAS occurred most frequently (18 out of 23) and the bulbar form was the most unfavourable. The need for regular epidemiologic examinations of LAS in the South of the Uzbek SSR is emphasized.

ABO Blood-Group System↗
PubMed1981

[Clinical picture of transitional forms between multiple and diffuse sclerosis].

A female patient is described in whom the disease clinical picture, as regards the localization of the multiple lesions in the nervous system (optic nerves, pyramid and cerebellar paths), the undulatory course of the process, and the characteristic manifestations (epileptic seizures, intellect derangement) combined symptoms of both disseminated and diffuse sclerosis. This allowed the author to think that this patient had a transitional form between the disseminated and diffuse sclerosis.

Adolescent↗
PubMed1979

[Facial neuritis in middle-aged and elderly patients].

The progress of facial nerve neuritis was studied clinically in 59 patients of middle and old age with atherosclerosis and arterial hypertension. The patients were divided into 3 groups. An inflammatory genesis of prosoplegia was established in the first group (12 cases). The second group (24 cases) showed symptoms of the inflammatory process with a predominance of vascular insufficiency. This circumstance hampered elucidation of the etiology of the disease, but pointed to crucial significance of vascular factors in the development of prosoplegia. The third group (23 cases) demonstrated a vascular nature of prosoplegia. It is assumed that the importance of insufficiency in the blood supply of the facial nerve in the etiopathogenesis of prosoplegia in most patients should be reflected in the approach to its treatment.

Adult↗