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Biomedical subjects

B A De Souza

Publications and source records attributed to B A De Souza.

14 recordsLinked to original sources
PubMed1986

Degenerated muscle grafts used for peripheral nerve repair in primates.

The basement membrane matrix of skeletal muscle has a tubular configuration resembling that of peripheral nerves. Grafts made of autogenous skeletal muscle denatured by freezing and thawing were used to repair the ulnar nerve in marmosets. By six months, normal hand function had returned and the grafts were shown to transmit normal compound extracellular action potentials in both directions. Morphological examination of the grafts and distal nerves revealed normal axon numbers and axon maturity. Myelination in the graft was found to take place more slowly than in the distal nerve segment. It is suggested that such grafts might be of use in the repair of human peripheral nerves.

Animals↗
PubMed1986

Nerve growth in cardiac muscle.

The failure of reinnervation after cardiac transplantation is probably a consequence of scar formation at the suture lines. However, it must be established whether there are any intrinsic properties of the muscle that prevent reinnervation. This is examined in experimental peripheral nerve implants using cardiac muscle isografts. The results show extensive growth of regenerating axons into the implanted cardiac muscle. It is therefore unlikely that the failure of reinnervation depends upon the physical or chemical properties of the muscle itself.

Journal Article↗