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Biomedical subjects

B A Ivin

Publications and source records attributed to B A Ivin.

At least 19 recordsLinked to original sources
PubMed1998

[Alkyl nitrosoureidodioxans and alkyl nitrosoureidopropane diols -- new groups of antitumor compounds].

1,3-dioxan- and 1,3-propane diol derivatives of alkyl nitrosourea have been synthesized and studied. Like other 2/chloroethylnitrosoureas, they exerted pronounced influence on a wide range of transplantable tumors, including those transplanted intracranially. Antitumor effect was found to depend on C5 and C2 atom substituent in the 1,3-dioxan cycle and 1,3-propane diol, respectively. The therapeutic effect and toxicity of 1,3-propane diol derivatives were higher than those of 1,3-dioxan. The substances lost all antitumor properties if a methyl group was substituted for the 2-chloroethyl one, even though a nitroso group was retained in their structure.

Animals↗
PubMed1998

[Antitumor activity and toxicity of combined doxorubicin and disodium salt of methylene-1,1-diphosphonic acid].

In experiments using mice and rats with transplantable Ehrlich ascites tumors, sarcoma-180 and adenocarcinoma of Walker, antitumor activity of doxorubicin in combination with disodium salt of 1,1-methylenediphosphonic acid proved higher than that of doxorubicin alone. Most advantage was gained with daily treatment. The toxic effect of said complex treatment seemed to differ slightly from that of doxorubicin as judged on the basis of survival, changes in body mass and peripheral blood count.

Animals↗
PubMed1998

[Multicenter clinical trial of the antitumor drug Dioxadet (phase II)].

A stage II of the joint clinical study of Dioxadet, an ethylene imine drug, was carried out to evaluate its therapeutic effect in 229 patients and side-effects in 239 patients with malignancies of various sites. Marked therapeutic effect was observed in ascitic malignancies of the ovary and a moderate one--in disseminated breast cancer. The most frequent side-effect was reversible myelodepression, often delayed.

Adolescent↗
PubMed1996

[The suppression of the repair of radio-induced DNA damage in Escherichia coli cells by indazolin derivatives and proksifein].

A study was made of the postradiation effect of five indasoline derivatives and proxyfeine on the survival rate and repair of DNA single-strand breaks in E. coli exposed to gamma-irradiation. Some indasoline derivatives (three substances) and proxyfeine added in postradiation medium in nontoxic concentrations decreased the survival rate of radioresistant strains WP2 hcr+, Hr30 and Hs30, but do not influence survival rate of radiosensitive mutant Bs-1. These substances inhibit the repair of DNA single-strand breaks in E. coli WP2 hcr+. Substances, which do not inhibit the survival rate of radioresistant strains, do not inhibit the repair of breaks. Proxyfeine in non-toxic concentrations in non-irradiated cells induces DNA degradation. Indazoline derivatives do not induce DNA degradation. Data presented suggest that indasolines are new class inhibitors of DNA repair. It is possible that proxyfeine is too an inhibitor of DNA repair.

Caffeine↗
PubMed1995

Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients.

The results of Sehydrin (Hydrazine Sulfate, HS) treatment of 740 patients with the advanced, recurrent or metastatic solid tumours of various localizations or malignant lymphomas, for whom all the methods of specific treatment (surgery, radiation, chemotherapy) had been exhausted are presented in this work. The objective response, symptomatic therapeutic effects and toxicity were estimated. Clinically significant objective responses were registered in patients with the soft tissue sarcomas, including neuroblastomas, and paradoxically--in such semimalignant tumours as desmoids. Although the objective response in patients with the lung cancer (90%--non-small cell) was only 4%, stabilization of long duration was registered in 22% of cases connected with the impressive relief of heavy common symptoms in 38.5% of the treated patients. Such a subjective response was established in 46.6% of all the 740 cases. The drug given per os was well tolerated by patients in primary and subsequent courses and did not induce myelosuppression or other significant side effects. On the basis of observations available, Sehydrin may be assessed as an alternative drug for the treatment and symptomatic therapy of patients with some advanced solid tumours and malignant lymphomas at a disease stage when the other methods of treatment can not be used. A possible mechanism of antitumour and symptomatic action is being discussed.

Adolescent↗
PubMed1994

[Therapy of primary brain tumors with segidrin].

The results of segidrin administration to 46 patients with malignant and 6 patients with benign tumors of the brain are presented. Pronounced therapeutic effect for the whole group was 63.5% and 73%, if partial regression of neurologic symptoms in the entire brain and separate foci is considered. These indexes for patients with malignant tumors only were 61 and 71.7%, respectively. Since segidrin has virtually no significant untoward side-effects, it is considered a most safe medicine for managing brain tumors. It is recommended in cases of inoperable tumor and for post-operative adjuvant chemotherapy with a view to extending the patient's survival time and improving the quality of life.

Adolescent↗
PubMed1994

[Basic and salvage pathways of NAD biosynthesis in organs of normal rats, tumor-bearing rats and in tumors].

The rates of quinolinic and nicotinic acids and nicotinamide utilization for NAD biosynthesis in organs of normal rats and those with lymphosarcoma of Pliss and Walker's carcinosarcoma were studied. All three compounds were shown to be NAD's precursors in the liver and kidneys of normal animals. Quinolinic acid failed to stimulate the increase in NAD concentration in the liver of Walker carcinosarcoma-bearing rats. An insignificant rise in NAD concentration was registered in the liver of rats with lymphosarcoma of Pliss following quinolinic acid treatment. The rates of nicotinic acid and nicotinamide utilization in the liver of tumor-bearing animals were lower than in healthy controls. Quinolinic acid utilization was the most intense in the kidney of rats with Walker's carcinosarcoma while nicotinic acid and nicotinamide were mostly utilized in the kidney of rats with lymphosarcoma of Pliss. None of the three precursors caused NAD concentration to rise in Walker's carcinosarcoma cells whereas nicotinamide injection was followed by an increase in NAD concentration in Pliss lymphosarcoma cells. To summarize, the neoplastic cells under study do not use the basic pathway of NAD biosynthesis and are characterized by different rates of nicotinic acid and nicotinamide utilization.

Animals↗
PubMed1990

[The results of a clinical study of the preparation hydrazine sulfate].

The paper discusses results of a cooperative study of effectiveness of hydrazine sulfate therapy in 740 patients with primary advanced, recurrent and metastatic solid tumors and malignant lymphomas who had failed all other treatment modalities. Both objective response and symptomatic effect were assessed. Objective response was observed in neuroblastoma, recurrent desmoid, Hodgkin's disease, lung cancer, fibrosarcoma and other tumors. Since hydrazine sulfate provided relief of a wide spectrum of cancer symptoms, it may be recommended for patients with end-stage cancer.

Adolescent↗
PubMed1989

Methylation of thymine and uracil with free methyl cations formed due to beta-decay of tritiated methane: possible implication in mutagenesis and carcinogenesis.

Exposure of solid thymine and uracil at room temperature to free methyl cations, produced due to beta-decay of tritiated methane, resulted in formation of their 1-, O2-, 3-, O4-, and 6-methyl derivatives. In addition, uracil formed a 5-methyl derivative (thymine); tritium-containing thymine and uracil were also detected. Both thymine and uracil formed predominantly unidentified products which resulted presumably from their oligomerization. Incubation at -195 degrees C did not markedly change the pattern of reaction products. Aqueous-ammonia solutions of these pyrimidines formed methylated derivatives and considerable amounts of methanol and tritiated water. The possible implication of these reactions in mutagenic and carcinogenic effects of tritium-substituted hydrocarbons is discussed.

Alkylating Agents↗
PubMed1985

[Antitumor activity and pharmacological properties of furizil].

The paper discusses the biological properties of 2-(2-furyl)-5-oxymethyl-5-(2,4-diethyleneimino-1,3,5-triazine- 6-yl) amino-1,3-dioxane (furizil), synthesized by substituting ethyleneimine groups for chlorine atoms in individual stereoisomer of a dichlorotriazine derivative. Furizil was found to inhibit the growth of Ehrlich's tumor, Walker's carcinosarcoma, sarcoma 45 and rat ovarian tumors, the inhibition rate ranging 76-100%. Parenterally administered, LD50 appeared to be 6 mg/kg for rats and 15 mg/kg for mice. Studies of chronic toxicity established damaging effects of furizil on hematopoietic, gastrointestinal and reproductive organs. Toxic effects subsided 1-2 weeks after the drug withdrawal.

Animals↗
PubMed1983

[Blood concentration of halothane and its effect on catecholamine levels and hemodynamics in cancer patients during surgery].

The investigation of 22 patients has established the concentration of fluothane in the blood to influence the catecholamine content and the cardio-vascular system. Its increased concentration in the blood results in certain decrease of the level of general catecholamines in the blood, decreased value of systolic arterial pressure and increased frequency of cardiac contractions.

Anesthesia, Endotracheal↗
PubMed1979

[Quantitative aspects of the relationship of the antitumor activity and toxicity of diaziridinyl-sym. triazines to their physicochemical properties].

The experiments on rats have shown that there is a linear dependence of the logarithms of reciprocal molar toxic (LD50) and therapeutic (ED50) for sarcoma 45 doses of 6-oxyalkyl-amino-2,4-bis(I-aziridinyl)-sym-triazines and 6-(5-substituted-2,2-dimethyl-1,3-dioxan-5-yl)-amino-2,4-bis(I-aziridinyl)-sym-triazines upon the induction constants of substituents at tertiary carbon, the antitumor activity being more sensitive to the substituent effect compared with the toxicity. The dependence of the logarithms of reciprocal molar therapeutic (ED50 for sarcoma 45 and ED95 for Walker sarcoma) and toxic (LD50 and LD100) doses of the compounds, both synthesized by us and taken from the literature, upon the logarithms of their distribution coefficients in the octanol-water system (IgP) shows a parabolic character with the maximum effect at the extreme point of the parabola. The antitumor activity was more sensitive to a changed IgP than the toxicity.

Animals↗