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Biomedical subjects

B A Kudriashov

Publications and source records attributed to B A Kudriashov.

At least 19 recordsLinked to original sources
PubMed1992

[Fibrinolytic complexes of low-molecular heparin and acetylsalicylic acid].

Complexes of low-molecular heparin with acetylsalicilic acid was formed in vitro when the weight ratio of components was 1:1, 1:5 and 5:1, respectively. All the complexes possessed fibrinolytic and anticoagulating activities. The complex possessed the highest activity when the ratio of heparin to acetylsalicilic acid was 5:1. This complex at a dose 1 mg/200 g of rat weight had the largest thrombolytic effect on the experimental fresh thrombus.

Animals↗
PubMed1990

[A method of determining the anti-, de- and fibrin-polymerization activity of the blood plasma].

The suggested method is based on measuring the changed level of polymerized fibrin monomer and nonstabilized fibrin under the effects of agents enhancing or inhibiting fibrin monomer polymerization. This method permits measurement of plasma specific activity influencing fibrin monomer and unstabilized fibrin polymerization in human and animal blood plasma in health and various diseases involving disorders of hemostasis system, as well as in various drug exposures.

Animals↗
PubMed1990

[Platelet aggregation induced by fibrinmonomer and the effect of the heparin-adrenaline complex or plasmin on this process].

Addition of purified fibrin-monomer in a concentration of 0.5 mg/ml induces aggregation in a suspension of washed rat platelets in the absence of aggregants. Maximum aggregation takes place 1-3 min after fibrin-monomer addition, and then the disaggregation phase follows. Complex heparin compounds with adrenalin or plasmin possessing antipolymerization and fibrinolytic activity with respect to ++non-stabilized fibrin prevent, or to a great extent decrease fibrin-monomer-induced aggregation of washed platelets.

Animals↗
PubMed1990

[Process of fibrin depolymerization and non-enzymatic fibrinolysis in rabbits receiving atherogenic rations with addition of antioxidants].

The rabbits were kept on atherogenic ration for 2 months. This diet contained 0.3 mg/kg of cholesterol. In blood plasma of animals the authors observed a sharply reduced non-enzymatic fibrinolysis and depolymerization activity of non-stabilized fibrin. The addition of antioxidants and alpha-tocopherol (10 + 10 mg/kg) for 1 month to the atherogenic ration protected from the disturbance of the system hemostasis and normalized the depolymerization of non-stabilized fibrin.

Animals↗
PubMed1990

[Effect of defensin on the process of healing of aseptic skin wound and on the permeability of blood vessels].

It was shown, for the first time, that polypeptide of rabbit's neutrophils, defensin (D) has the ability to accelerate the reparation process (RP). D was infused intramuscular to rats (125 micrograms/kg) 2 days before the operation, then the skin on the back was dissected through all layers (the length of the wound was constant-10 mm). The rate of the RP was estimated by the changes of the wound length on 2, 5, 7, 13-15 days after the operation. The injection of D or physiological solution was continued during 2 weeks. It was shown, that beginning from the fifth postoperative day the RP in the experimental rats developed faster, than in control rats. In the experimental group the full reparation appeared earlier, than in the control group (on 21-22 and 24-26 days correspondingly. Qualitative (with trypan blue) and semi-quantitative (with colloid coal) methods have shown, that D augmented the permeability of blood vessels. It was proposed, that the RP acceleration was induced by D augmentation of the blood vessels permeability.

Animals↗
PubMed1988

[Function of the anticoagulant system when difensin is administered into the blood stream].

I. v. administration of defensin, nonenzyme cationic protein consisting of some peptides, to the rats with either activation or depression of anticoagulating system produced a moderate decrease of anticoagulating and fibrinolytic properties of the blood and did not intensify the depression of anticoagulating system. Neither did defensin affect the response of anticoagulating system when administered prior to injection of tromboplastin. These properties of defensin make it an efficient hemostatic drug.

Animals↗
PubMed1987

[Inhibitor of nonenzymatic fibrinolysis from spleen tissue].

A homogeneous protein factor was obtained from healthy rat spleen tissue. The factor selectively inhibited non-enzymatic fibrinolysis both in vitro and in vivo in normal functioning of anticoagulating system as well as in activation and depression of this system. The duration of the factor action in the blood stream ia about 1.5 hrs.

Animals↗
PubMed1986

[Dependence of the blood plasma activity of the diabetogenic factor in animals on the functional depression of the anticoagulating system induced by an atherogenic diet].

It has been found that in blood plasma of rats keeping on an atherogenic diet for a long time the diabetogenic factor activity appears. The direct dependence between the level of the diabetogenic factor activity and the degree of the anticoagulating system depression caused by long keeping of the animals on the atherogenic diet has been revealed.

Animals↗
PubMed1986

[Hemostatic system function as affected by thromboplastic agents from higher plants].

It has been determined that the thromboplastic agents from the inflorescence of the birch Betula pendula Roth, blossoms of the willow Salix daphnoides Vill., seeds of the pea Pisum sativum L. provoke protective reaction of the animal's anticoagulation system, though weaker expressed than the reaction of thromboplastin from brain. The mechanisms of action of thromboplastic agents of plant origin is similar to the mechanism of action of tissue thromboplastin.

Animals↗
PubMed1986

[Role of the diabetogenic factor in hypercoagulation of the blood].

I.v. injection of the diabetogenic factor induced disfunction of anticoagulation system in rats. The endogenous heparin concentration decreases in the blood and no proper defensive response to thrombosis provocation occurs. The diabetogenic factor seems to play an important role in the development of thrombosis and other complications in diabetes.

Alloxan↗
PubMed1986

[Prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin administration].

The possibility of prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin devoid of proteolytic activity and capable of stimulating the reaction of anticoagulation system was studied. The injection of lethal thromboplastin dose was shown to produce a sharp increase in soluble fibrin blood content, total disappearance of fibrinolytic activity and intravascular blood coagulation. The animals died of thrombosis in 90% of cases. It was established that the injection of lethal thromboplastin dose 5 min after DIP-alpha-thrombin injection caused a 13% lethality from thrombosis. No reliable changes in fibrinolytic activity and soluble fibrin content were observed. A significant increase in thrombin and recalcification time was recorded. It is suggested that DIP-alpha-thrombin prevents intravascular blood coagulation induced by lethal thromboplastin dose due to mobilization of the reserve capacities of neuro-humoral anticoagulation system.

Animals↗