Single dose peroperative antibiotic prophylaxis in gastro-intestinal surgery.
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Biomedical subjects
Publications and source records attributed to B A Shorey.
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In Britain abdominal tuberculosis is an uncommon condition and most cases come to laparotomy for diagnosis. A high index of suspicion is required in areas with a large immigrant population and in areas which are overcrowded and nutritionally deprived. Nine of 28 patients presented acutely and a wide variety of preoperative diagnoses were entertained. Most of the remainder had a long history of vague constitutional symptoms and laparotomy was required for diagnosis in all but 5. Histology proved the surest way of establishing the diagnosis.
Three symptomatic cases of congenital solitary cyst are reported, one in the liver and two in the spleen. Recurrence of the hepatic cyst after partial excision and drainage was complicated by fistula formation between the cyst and the duodenum. The fistula was successfully closed at a second operation. Calcification of the cyst wall occurred in one of two epithelial cysts of the spleen in young women, which were treated by splenectomy. Besides their rarity, congenital solitary cysts of the liver and spleen have several other features in common. Isotopic and ultrasonic scanning assist diagnosis in both conditions.
A case of carcinoma of the gall bladder presenting as a retrograde intussusception of the duodenum is described. Although this is a rare presentation of the disease, adequate radiography and endoscopy will help to establish the diagnosis.
A case of Behçet's syndrome with mucosal ulcerations of the ascending colon and three perforations of the caecum is described. It is the first documented case of this syndrome where colitis has occurred without concomitant rectal lesions. The reported cases of Behçet's syndrome with associated colonic lesions make up a heterogeneous group. It is suggested that the different patients may have suffered from pathogenetically different diseases.
A single intravenous dose of tobramycin and lincomycin, given at the start of gastrointestinal operations, significantly reduced the incidence of postoperative wound infection from 34% to 5%. The occurrence of both anaerobic and aerobic bacteria was reduced. Therapeutic concentrations of the antibiotics were maintained throughout the operative period in most cases. No toxic effects of the antibiotics were detected, no anaesthetic complication occurred, and resistant strains of bacteria normally sensitive to the antibiotics were not isolated from wounds.
Seven patients are presented each with symptomatic malignant melanoma metastases to the alimentary tract. Where practicable, surgical excision of the metastases is justified because two patients have had worthwhile periods of survival.
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The method of using phenol injections for the treatment of pilonidal sinus is described in detail. This is a simple, safe and painless method which may be used as a day case procedure. The results are discussed and compare very favourably with the more radical forms of treatment.
Peroperative pancreatic aspiration biopsies were performed on 21 patients with pancreatic lesions using a standard 20-ml disposable syringe and a 21-gauge needle. No complications were recorded which could be attributed to this procedure. A further 10 aspiration biopsies were carried out on postmortem specimens in an attempt to determine the accuracy of this method in the diagnosis of carcinoma of the pancreas. It is concluded that peroperative pancreatic needle biopsy is a safe procedure which is easily performed without special instruments. In can be of enormous value to the surgeon in planning the treatment of patients with pancreatic lesions. In cases where there is an operable mass in the pancreas it offers a simple and quick method of determining the presence of malignant cells and thus definitive surgery may be performed with confidence. For the inoperable cases it offers a method of histological confirmation of the operative findings.
Two cases of adenocarcinoma of the bowel occurring in association with Crohn's disease are described. The first affected the terminal ileum and the second the terminal ileum and caecum. The 28 cases so far described in the world literature are briefly reviewed. It is suggested that adenocarcinoma of the small bowel may be a complication of longstanding Crohn's disease. Eleven patients developed the carcinoma in a surgically bypassed segment of bowel, and it is therefore recommended that where surgery is undertaken excision rather than bypass should be the treatment of choice.
An analysis is presented of 247 retropubic prostatectomies performed under hypotensive anaesthesia using a non-catheter technique wherever possible. The mortality rate was 2% which compares favourably with other series. A catheter was not used postoperatively in 67% of the patients operated on by the consultant in charge. Even when those operated on by the registrars in training are considered well over half did not require a catheter. It is suggested that this procedure should be adopted more widely in view of its safety, lack of complications, and increased patient comfort.
Incompetent perforating veins of the legs were located by dynamic thermography at 69 sites and by the fluorescein test at 31. All the sites were explored by multiple local incisions. Incompetence of the veins was determined by demonstrating retrograde blood flow through these veins when severed. Explorations of these sites showed that thermography detected 94% and gave false-positive results in 6%, while the fluorescein test detected 16% and contributed 84% false-positive results. These findings show a highly significant difference (P <0.0005) in favour of the thermographic technique. Detection of 16% of incompetent perforating veins by the fluorescein test is statistically insignificant. This inaccuracy is thought to be due to inadequate dermal penetration of the ultraviolet rays. A positive fluorescein test probably indicates the presence of incompetent perforating veins but has little anatomical relationship to their actual site.