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Biomedical subjects

B A Smithurst

Publications and source records attributed to B A Smithurst.

At least 19 recordsLinked to original sources
PubMed1989

The pharmacokinetics of amiloride-hydrochlorothiazide combination in the young and elderly.

The pharmacokinetics of amiloride and hydrochlorothiazide were studied in 12 healthy young volunteers following a single dose of a fixed combination of amiloride and hydrochlorothiazide and in 11 elderly hypertensive patients at steady-state. Following modelling of the single dose data, simulated steady-state plasma concentrations for the 2 drugs were generated to examine the effect of age and/or hypertension on pharmacokinetics. The apparent systemic plasma clearance for both amiloride and hydrochlorothiazide was significantly reduced in the elderly when compared to the young (from 753 to 325 ml.min-1, amiloride; and from 418 to 157 ml.min-1, hydrochlorothiazide). The plasma concentrations at steady state for both drugs were greatly increased in the elderly patients (Amiloride: from 7 to 25 ng.ml-1, Css,max; from 2 to 8 ng.ml-1, Css,min; and from 4 to 14 ng.ml-1, Cav; Hydrochlorothiazide: from 184 to 651 ng.ml-1, Css,max; from 31 to 121 ng.ml-1, Css,min; and from 89 to 273 ng.ml-1, Cav). The decreased clearance of the diuretics in the elderly was believed due to deterioration of renal function, and there was a significant correlation between the plasma clearance of hydrochlorothiazide and creatinine clearance in both age groups (r = 0.62, young; r = 0.72, elderly). As a result of the pharmacokinetic findings caution may be indicated in the clinical dosage of the diuretics particularly when in fixed dose combination.

Adult↗
PubMed1989

Implications of AIDS for teachers of medicine to dental students.

A plea is made for a significant input on AIDS to the dental undergraduate curriculum by medical teachers. The suspicion is that in some schools the teaching of medicine to dental students is not treated seriously. Figures are quoted depicting the worldwide spread of AIDS. The risk of dentists acquiring HIV in the health care setting is discussed. Mention is made of infection control in the dental environment. The objectives are given of a medical curriculum for dental students. Some of the oral manifestations of AIDS are named. Symptoms and signs (which a dentist should be able to recognize) are given for pulmonary, neurological, gastrointestinal or neoplastic complications that may be found in HIV infection. The role of the dentist is stressed in continuing surveillance of patients with HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1989

HIV and the dental undergraduate.

Reasons are offered as to why it is imperative that the dental undergraduate is familiar with all aspects of AIDS. The epidemiology of the disease is discussed, as are methods of transmission of the virus. A classification is given of the clinical presentation of HIV infection. The classification is based on the system put forward by the Centers for Disease Control, Atlanta. A brief résumé is given of laboratory diagnosis in HIV infection, and of the risk of health care workers contracting the disease. The precautions recommended for use in dentistry as proposed by the Centers for Disease Control are quoted in full. Finally mention is made of the treatment and control of AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1976

The care of diabetes mellitus at a community health centre.

Diabetes mellitus is a chronic disease with a high prevalence of about 2.0 per cent in the australian community. Although hospital diabetic clinics play an important role in the management of diabetic patients, the majority are managed by their local doctor. In this article the possible role of a health centre in the care of diabetics is outlined.

Ambulatory Care↗
PubMed1975

Social background of 171 women attending a femal venereal disease clinic in Brisbane.

A survey over 12 months was carried out on 171 women and girls attending the State Health Department Women's Clinic in Brisbane. Each person was interviewed to obtain data on occupation and educational and family background, attitude to sex, knowledge of venereal disease and other pertinent attitudes. It was obvious that most patients came from lower socioeconomic groups and had little knowledge of venereal disease. The former finding may have been because women from the upper middle and professional classes seek private advice. The need for social workers in venereal disease clinics has been emphasized.

Abortion, Induced↗