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Biomedical subjects

B A Tsudzevich

Publications and source records attributed to B A Tsudzevich.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[ATP metabolism under conditions of radiation injury and the ways of its modification].

Content, methylation and an intensity of restoration of phosphoric components of ATP were studied in cross-striated muscles, brain and liver tissue of normal animals. These patterns were also studied in animals, subjected to irradiation: within 3 hrs after X-ray treatment (800 r); with subcutaneous administration of prozerine (0.5 mcg/kg) and nicotinic acid (20 microng/) 4 hrs before decapitation; and also in animals with vagus, cut off at the level of neck two weeks before irradiation. In different experimental conditions the character of regularity and interrelation between methylation and phosphorylation of ATP were established.

Adenosine Triphosphate↗
PubMedDate not supplied

[Kinetic characteristics of Ca2+-phospholipid-dependent protein kinase from the rat liver in the early stages after x-ray irradiation].

The changes of kinetic characteristics (apparent Km and Vmax) of the Ca2+ phospholipid-dependent protein kinase (protein kinase C) from the rat liver for substrates ATP and histone Hl 2 and 24 hours after total X-ray irradiation have been established. The obtained results evidence for the important role of these changes in early radiosensitivity of protein kinase C.

Adenosine Triphosphate↗
PubMedDate not supplied

[The possibility of using the preparation MIGI-K in districts exposed to radioactive contamination following the accident at the Chernobyl AES].

A preparation from mussels, MIGI-K, used as an additive to the diet of people working at the Chernobyl power plant has proved to be efficient in increasing the total resistance of the body, including the resistance to ionizing radiation. In experiments with animals, MIGI-K has been shown to accelerate excretion of 45Ca and 86Rb from the body. The combination of these properties of MIGI-K permits us to consider it an efficient drug to be used within the regions affected by the Chernobyl disaster.

Accidents↗
PubMedDate not supplied

[Activity of antioxidant system enzymes and lipid peroxidation product content in the liver and thymus of rats in the early stages of irradiation].

The activity of enzymes of the antioxidation system and the content of some lipid peroxidation products in the liver and thymus of irradiated (0.21 C/kg) rats have been investigated. Glutathione reductase and glutathione transferase activity in the liver and thymus of rats decreased during the first 24 h after irradiation. There was a phase change in the catalase activity during the initial postirradiation period. The content of malonic dialdehyde increased immediately after irradiation and somewhat decreased during the first 24 h. In 24 h, there observed a radiation-induced increase in the diene conjugate content in the liver and thymus of rats, against the background of low activity of such antioxidation system enzymes as glutathione transferase, glutathione reductase and catalase.

Animals↗
PubMedDate not supplied

[The biological effects in animals in relation to the accident at the Chernobyl Atomic Electric Power Station. 7. The content of lipid peroxidation products and free fatty acids and the catalase activity in a number of organs and tissues of rats].

The content of malonic dialdehyde, dienic conjugates and free fatty acids, and catalase activity were determined in some organs and tissues of chronically irradiated rats. Certain regularities were found in lipid metabolism changes. The MIGI-K preparation was shown to normalize some indices under study.

Accidents↗
PubMedDate not supplied

[The content of phospholipids and free fatty acids in the sarcoplasmic reticulum membranes in the early stage of an x-ray radiation lesion].

One and 24 h following single X-irradiation (0.21 C/kg) of rabbit hind leg the content of free fatty acids and phospholipid lysoforms increased in the sarcoplasmic reticulum (SR) membrane of skeletal muscles. The results obtained are important in estimating the mechanisms of action of ionizing radiation on the structural and functional properties of SR.

Animals↗
PubMedDate not supplied

[Electrogenic activity of Ca2+-ATPase fragments of the sarcoplasmatic reticulum during the early stages of radiation injury].

It is established that local X-ray irradiation of the rabbit hind limb produces a decrease in Ca2+, Mg2+-ATP-dependent formation of electric potentials difference on the membrane of the sarcoplasmic reticulum (SR). These results agree with the observed decrease in the Ca2+-ATPase activity of SR membranes and increase in their electric conduction after irradiation.

Animals↗
PubMedDate not supplied

[Cyclic nucleotide levels in the regenerating liver of rats following irradiation and protection by serotonin].

Changes in cAMP and cGMP levels after X-irradiation and radioprotective treatment with serotonin were studied using a model of impulse inhibition and repair of transcription, translation and replication by cycloheximide in rat hepatocytes in vivo. Irradiation was shown to inhibit the cyclic nucleotide synthesis. Serotonin increased the contents of cAMP and cGMP maintaining their elevated level after X-irradiation.

Animals↗
PubMedDate not supplied

[Study of the effect of phosphorylation of histones on their interaction with DNA-cellulose].

Data about the influence of phosphorylation levels of histones isolated from the prereplicative and replicative phases induced to proliferation by cycloheximide of rat hepatocytes, on their interaction with DNA-cellulose are presented. It is shown that the DNA-cellulose chromatography of histones is a sensitive model for the investigation of the effect of phosphorylation of histones on their electrostatic interaction with DNA. Using this method it is possible to separate high-phosphorylated subtype of rat liver H1 histones from other subtypes and also to show a direct dependence between the phosphorylation levels of histones and stability of their binding with DNA in prereplicative and replicative phases not only under conditions of proliferation induction by cycloheximide, but also under the subsequent influence of X-irradiation and serotonin.

Animals↗
PubMedDate not supplied

[Effect of irradiation on the intensity of chromatin protein synthesis in the rat liver during protection with serotonin in pulsed inhibition of translation by cycloheximide].

The model of impulse translation inhibition by cycloheximide in the rat liver was used for studying the combined and separate effect of serotonin and irradiation on the intensity of synthesis of chromatin proteins (histones and nonhistone proteins). Irradiation induces a considerable inhibition of the protein synthesis intensity, while serotonin has a contrary action, that under conditions of subsequent irradiation provides an increase in the synthesis level of histones and nonhistone proteins. Possible mechanisms of the irradiation and serotonin effect on the synthesis processes of chromatin proteins in the organism are discussed.

Animals↗
PubMedDate not supplied

[Adenylate cyclase system and structural modifications of nuclear proteins in organisms radioprotection].

The paper deals with modern ideas of ways and mechanisms for realization of the radioprotector antiradiation effect. The data on the effect of biogenic amines (serotonin in particular) and radiation on the cAMP system are analyzed. It is shown that one of the most important mechanisms of the radioprotective effect is realized by changing the levels of histones and nonhistone proteins modifications through the adenylate cyclase system which leads to regulation of the chromatin template activity.

Adenylyl Cyclases↗