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Biomedical subjects

B A Waisbren

Publications and source records attributed to B A Waisbren.

At least 19 recordsLinked to original sources
PubMed1987

Observations on the combined systemic administration of mixed bacterial vaccine, bacillus Calmette-Guerin, transfer factor, and lymphoblastoid lymphocytes to patients with cancer, 1974-1985.

Herein are reported the results of treating 139 cancer patients with combined immunomodulation that consisted of bacillus Calmette-Guerin, transfer factor, and mixed bacterial vaccine. In addition 28 patients were given infusions of lymphoblastoid lymphocytes. Patients were admitted to this treatment program who either had failed to respond to other modalities, had elected to add immunomodulation to usual therapy, or had refused chemotherapy and/or radiation therapy. The results suggested that combined immunomodulation therapy is well tolerated and safe and that this approach on a prima facie basis had a salutary effect on the courses of a number of the patients treated. The results also illustrate alternative pathways that can be taken by patients and physicians who are not comfortable with protocolized double-blind methods of approaching patients with poor prognosis cancer.

Adolescent↗
PubMed1985

The benefits of systematic fiberoptic flexible sigmoidoscopy.

We used the flexible fiberoptic sigmoidoscope (FFS) on 656 subjects who were receiving their yearly physical examinations. Neoplastic disease was disclosed by the FFS in 138 subjects (21%), including 26 adenocarcinomas, 19 of which were out of reach of a rigid sigmoidoscope. Nineteen of the subjects whose adenocarcinomas were found by the FFS had barium enemas, which detected the carcinomas in only 11. Routine FFS in asymptomatic persons is helpful in detecting both premalignant and malignant lesions, it should be seriously considered as a part of regular preventive physical examinations.

Adenocarcinoma↗
PubMed1982

Hyperbaric oxygen in severe burns.

When a preliminary analysis suggested that treatment with HBO might cause an increased mortality due to HBO, a paired control study of 36 patients treated with HBO and 36 matched controls was carried out. While mortality, mean day of death, and total hospital days were the same between the two groups, the HBO group suffered more kidney damage, had more positive blood cultures. The paired control method showed that the increased mortality observed in both groups of patients studied was not due to HBO treatment but to some other undetected selection factor. The findings that the HBO-treated patients had increased sepsis and renal damage warrants further investigation.

Acute Disease↗
PubMed1980

Morphological expressions of antibiotic synergism against Pseudomonas aeruginosa as observed by scanning electron microscopy.

Antibiotic-induced changes in Pseudomonas aeruginosa were observed by means of a scanning electron microscope. Seven frequent and five less frequent morphological changes were noted. The frequent changes were: (i) elongation; (ii) chain formation; (iii) nub formation; (iv) spheroplasts; (v) surface holes or pits; (vi) super-elongation; and (vii) increased filamentation. The less frequent changes were: (i) rounded ends; (ii) streptococcal forms; (ii) stalked nubs; (iv) surface bulges; and (v) convoluted surfaces. A morphological equivalent of antibiotic synergism was found in which changes were noted due to synergistic combinations of antibiotics that were not observed when the antibiotics were used alone or when a nonsynergistic combination of antibiotics was used.

Anti-Bacterial Agents↗
PubMed1979

Human lymphocyte-tumor cell interaction. A scanning electron microscopy study.

Cells from the metastatic chest wall lesions of a patient with adenocarcinoma of the breast were incubated with autologous lymphocytes. Their interactions were observed in the scanning electron microscope. The lymphocytes first surrounded the cancer cells; cancer cells then were destroyed while the lymphocytes in contact with them lost their microvilli. The heterologous human lymphocytes being used as controls surrounded the tumor cells but did not destroy them. Lymphocytes in the presence of tumor cells showed interconnections through cytoplasmic bridging.

Adenocarcinoma↗
PubMed1979

Morphologic expression of the interactions of human lymphocytes and Pseudomonas aeruginosa as observed by scanning electron microscopy.

When human lymphocytes and Pseudomonas aeruginosa were incubated together and then observed under the scanning electron microscope, four distinct morphologic observations were made: (1) filopods extending between lymphocytes and bacteria; (2) globular structures bulging out in many of the filopods; (3) filopods connecting lymphocytes to each other in the presence of bacteria; and (4) bacteria adhering to the lymphocytes in areas where decreased numbers of microvilli were present.

Adult↗
PubMed1979

Comparison of methods of predicting burn mortality.

Recent suggestions that patients "hopelessly burned" be permitted to die peacefully have refocused attention on the accuracy of different methods of predicting whether an individual burn patient will survive. The purpose of this presentation is to compare the accuracy of mortality predictions based upon four different statistical methods: (1) Baux's rule which adds the patient's age in years to the percentage of his body surface area burned--the original assertion was that values over 75 meant a very poor prognosis. (2) probit analysis, (3) discriminant analysis, and (4) logistic risk function analysis. Each of these methods was applied to data for over three thousand consecutive admissions to St. Mary's Hospital Burn Center in Milwaukee, Wisconsin. This data base and the four statistical models are described. Mortality predictions derived from the four models are compared, and some observations are made concerning the selection of an appropriate model for predicting burn mortality.

Adolescent↗