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Biomedical subjects

B A Webber

Publications and source records attributed to B A Webber.

At least 19 recordsLinked to original sources
PubMed1994

The Flutter VRP1 as an adjunct to chest physiotherapy in cystic fibrosis.

The Flutter VRP1 (Flutter) is claimed to increase the clearance of excess bronchial secretions and to improve lung function and oxygenation, but these claims were based on computer models, laboratory assisted experiments and uncontrolled clinical trials. A prospective randomized clinical trial was undertaken, in subjects with cystic fibrosis, using the active cycle of breathing techniques as the 'gold standard'. The claims could not be substantiated and the possibility of sputum retention was of concern when the Flutter was used as significantly more sputum (P < 0.001) was cleared with the active cycle of breathing techniques alone. There were no significant changes in lung function or oxygenation.

Adult↗
PubMed1990

Effect of chest physiotherapy on oxygen saturation in patients with cystic fibrosis.

Decreasing arterial oxygen saturation has been reported in patients with cystic fibrosis during postural drainage when this was combined with other manoeuvres, which did not, however, include thoracic expansion exercises or pauses for relaxation and breathing control. When these features were included in an active cycle of breathing techniques during postural drainage in 20 patients with cystic fibrosis there was no fall in arterial oxygen saturation during the procedure (mean values 87.1%, 87.9%, and 86.7% before, during, and after treatment).

Adult↗
PubMed1986

Effects of postural drainage, incorporating the forced expiration technique, on pulmonary function in cystic fibrosis.

Detailed pulmonary function tests were performed on 12 patients with cystic fibrosis (CF) before and after 3 days treatment with postural drainage incorporating the forced expiration technique. The results following treatment showed a statistically significant improvement in FEV1 (P less than 0.001), FVC (P less than 0.001), PEFR(P less than 0.001), PIFR (P less than 0.001), and VEmax50 (P less than 0.025). The study demonstrates objective benefit from this form of physiotherapy in cystic fibrosis patients with copious bronchial secretions.

Adolescent↗
PubMed1986

Evaluation of positive expiratory pressure as an adjunct to chest physiotherapy in the treatment of cystic fibrosis.

It has been suggested that positive expiratory pressure may assist the clearance of bronchial secretions in the treatment of cystic fibrosis. It has been compared with currently used postural drainage techniques. Three treatment regimens were compared in 18 patients with cystic fibrosis. Treatment A consisted of breathing exercises emphasising inspiration, interspersed with the forced expiration technique in gravity assisted positions; treatment B comprised breathing exercises with positive expiratory pressure alternating with the forced expiration technique in the same gravity assisted positions; and treatment C comprised breathing exercises with positive expiratory pressure and the forced expiration technique in the sitting position. During treatment A a significantly greater quantity of sputum was produced than during treatments B and C (p less than 0.025 and p less than 0.001 respectively). Treatment B produced more sputum than treatment C (p less than 0.005). There were no significant differences in arterial oxygen saturation, FEV1 or forced vital capacity. Most adolescent and adult patients are able to carry out their treatment independently using gravity assisted positions, breathing exercises emphasising inspiration, and the forced expiration technique. Sputum clearance was less effective when positive expiratory pressure was included in the treatment regimen.

Adolescent↗
PubMed1983

Assessment of the forced expiration technique, postural drainage and directed coughing in chest physiotherapy.

The Forced Expiration Technique (FET), postural drainage (PD) and directed coughing have been evaluated in 10 patients with copious sputum (mean value 63.3 ml/24 h) with an inhaled radioaerosol method over a 30-min treatment period. FET alone and FET + PD (but not directed coughing) cleared more radioaerosol than during the control period (P less than 0.01). The wet weight of sputum obtained following FET, FET + PD and directed coughing were all significantly greater than control (P less than 0.01). However, sputum obtained by FET + PD was significantly greater than FET alone (P less than 0.05). Both FET and particularly FET + PD have been shown to be more effective than directed coughing alone and it is suggested that these manoeuvres should be incorporated into standard chest physiotherapy.

Adult↗
PubMed1982

Severe acute asthma: a comparison of three methods of inhaling salbutamol.

The effects of salbutamol inhaled by three different methods were compared in groups of adult patients with severe acute asthma. 2 x 400 micrograms Rotacaps was the optimum dose of dry powder but about 40% of patients failed to respond to it. 5 mg salbutamol nebulized with IPPB resulted in a significant increase in peak expiratory flow rate when given before or after either Rotacaps or salbutamol nebulized without IPPB, whereas neither the dry powder nor the nebulized drug without IPPB resulted in significant change when given after salbutamol nebulized with IPPB. The extra benefit derived with IPPB is only slight and requires a device of appropriate characteristics. Occasional patients fail to respond to salbutamol inhaled by any means, generally those with the most severe airflow limitation.

Acute Disease↗
PubMed1979

Evaluation of the forced expiration technique as an adjunct to postural drainage in treatment of cystic fibrosis.

Sixteen patients with cystic fibrosis were treated with conventional physiotherapy aided by an assistant. The results were compared with those produced by physiotherapy using the forced expiration technique cleared more sputum in less time than conventional physiotherapy. A sputum in less time than conventional physiotherapy. A second study showed that an assistant did not further improve the results obtained by the patient performing the forced expiration technique himself. These findings mean that patients with cystic fibrosis who have had to rely on the help of others for their home treatment may now perform more effective treatment without help. The forced expiration technique might also be helpful for patients with chronic bronchitis, asthma, or bronchiectasis.

Adolescent↗
PubMed1979

IPPB and hypercapnia in respiratory failure: the effect of different concentrations of inspired oxygen on arterial blood gas tensions.

Fourteen patients with acute exacerbations of chronic bronchitis and hypercapnia received two treatment periods with Intermittent Positive Pressure Breathing, the ventilator being driven by gas containing about 24% or about 45% oxygen. Arterial PO2 and PCO2 were measured before, during and after each treatment. The results demonstrated that increasing hypercapnia did not, as a rule, occur when 45% oxygen was used as the driving gas. When hypercapnia did occur it appeared to be independent of the inspired oxygen concentration. The importance of short treatment periods, correct ventilator settings and supervision of the patient during and after treatment is emphasised.

Carbon Dioxide↗
PubMed1977

Effects of sputum on pulmonary function.

The specific airways conductance (SGAW) of 23 patients with copious sputum production and airflow obstruction was measured before and after physiotherapy to determine the effect of bronchial secretions on pulmonary function. Chest physiotherapy to remove these secretions had the effect of reducing airflow obstruction, as measured by SGAW. These findings suggest that sputum has a detrimental effect on pulmonary function and that physiotherapy can reduce airways obstruction.

Adolescent↗