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Biomedical subjects

B Adelusi

Publications and source records attributed to B Adelusi.

At least 19 recordsLinked to original sources

Pretreatment urographic evaluation in invasive carcinoma of the cervix uteri.

The urographic findings in 52 patients with histologically proven carcinoma of the cervix were studied. Obstructive changes observed were classified according to the severity of calyceal distension and related to the clinical staging of the disease. Obstructive urographic changes were present in 46% of cases, which is three times as high as reported in Caucasian populations, and the severity correlated significantly with the stage of disease. Urography is advocated as a useful pre and post-treatment index of the progress of cervical treatment.

Adult

Reproductive performance after eclampsia.

Eclampsia is a common complication of pregnancy in Ibadan, although its long term effects on subsequent pregnancies is unknown. In a prospective study of 64 women who had eclampsia in their previous pregnancies and were followed up in their current pregnancies, 15.6% of them had recurrent eclampsia, in spite of optimal antenatal care. Of the 18 patients with diastolic blood pressure of 80 mmHg 22.2% or over at booking had antepartum or intrapartum eclampsia as compared with only 2.2% of 46 patients with diastolic blood pressure of less than 80 mmHg at booking. This finding was statistically significant (P less than 0.01), showing that the diastolic blood pressure at booking can be a measure of the potential for developing eclampsia because of the possibility of residual hypertension on which pre-eclampsia may be superimposed. Similarly, there was a significant association (P less than 0.05) between the birthweight of the babies and the diastolic blood pressure at booking, and may be a measure of the effect of vascular effect of pre-eclampsia on the placenta. However, there was no difference in the perinatal mortality rate in this study and the overall hospital figures in spite of the high risk pregnancies being managed. It was concluded, therefore, that the outcome of these pregnancies would depend much on the standard of antenatal care provided for the patients.

Adolescent

Sero-epidemiology of type--2 (genital) herpes simplex virus infection in Ibadan.

Herpes Type 1 (HT-1) virus infection is prevalent in Ibadan, Nigeria. In a study to determine the prevalence of Herpes Type-2 (HT-2) virus infection in this environment by the complement fixation (CF) test, it was shown that antibodies to the virus were not found below the age of 14 years, after which there was a gradual rise from the 16-25-year age group to a peak in the 26-35-year age group. It was suggested that the pattern of distribution of HT-2 antibodies is compatible with the sexual habits of the different age groups, and is in support of the venereal mode of transmission of the virus.

Adult

Histopathological studies of carcinoma of cervix uteri in Ibadan.

Carcinoma of the cervix is by far the commonest gynecologic malignancy in Ibadan. In a histopathologic study of the disease, 93.9% of all the cases were found to be of the squamous cell carcinoma variety while 6.1% were of the adenocarcinoma group. It was found that most patients with the well differentiated squamous cell carcinoma were above the age of 45 years in contrast to the undifferentiated carcinoma. Even though the difference was not statistically significant, it was speculated that cervical cancer manifesting itself before the age of 45 years may be more aggressive than that occurring in older women. Similarly, it was shown that increasing age, more frequent marriages and parity may augment the possibilities, at least in the negro population, of a woman developing adenocarcinoma of the cervix.

Adenocarcinoma

Carcinoma of the cervix uteri in Ibadan: coital characteristics.

Carcinoma of the cervix uteri has been found to be the most common female malignancy in Ibadan, excluding the reticuloendothelial tumors. In a study to investigate associated etiological factors in this environment, it was demonstrated that certain coital characteristics of women with cervical cancer can be identified. These were a common denominator which could explain the frequency of the disease among some categories of patients who engage in early sexual practice, have intercourse frequently and with multiple partners, and have many pregnancies. Support was given to the view that a sexually transmitted factor might be important in the cause of carcinoma of the cervix.

Adolescent

Sero-epidemiology of herpes type-2 virus and carcinoma of the cervix in Ibadan.

Various sero-epidemiologic studies, including the preliminary report from Ibadan, have established that most women with premalignant and malignant carcinoma of the cervix have serologic evidence of infection of herpes type-2 virus. Using immunofluorescence method, the earlier report in Ibadan was confirmed, whereby the prevalence of HT-2 virus antibodies was shown to be significantly associated with carcinoma of the cervix, especially the squamous cell type. However, there was no such association with the grade and stage of the disease.

Adult

Haemoglobin genotype, ABO blood groups and carcinoma of the cervix.

Genetic factors have been suggested as having a possible aetiological role in the incidence of carcinoma of the cervix. With the high frequency of carcinoma of the cervix in Ibadan as well as the high incidence of sickle-cell trait, the haemoglobin genotypes and ABO blood groups were analysed in patients managed for carcinoma of the cervix uteri in the University College Hospital, Ibadan. No significant association was found between any haemoglobin genotype or blood group and carcinoma of the cervix. The protection afforded against malaria by the haemoglobin S trait does not seem to protect against the development of invasive carcinoma of the cervix.

ABO Blood-Group System

Herpes type-2 viruses and gynaecological malignancies.

Numerous sero-epidemiologic studies have noted an association between Herpes Type 2 (HT-2) virus and carcinoma of the cervix. In a study to evaluate the role of this virus, if any, on the etiology of extra cervical pelvic malignancies in Ibadan, the prevalence of HT-2 virus antibodies was found not to be significantly different in patients with extra cervical pelvic malignancies (carcinoma of the vulva and malignant trophoblastic disease) and cases of chronic cervicitis when compared with healthy controls. It was therefore concluded that no association could be found between HT-2 virus and extra cervical pelvic malignancies.

Adult

Polycystic ovaries. Presentation and response to wedge resection.

Polycystic ovarian disease has been recognised for quite a long time, although its presentations have varied from place to place. In a report of cases of polycystic ovaries seen in the University College Hospital, Ibadan, Nigeria, over a six-year period, it was shown that the syndrome of Stein-Leventhal identifies only a very small and probably artificial fraction of the much larger number of patients who actually have polycystic ovarian disease. It was further shown that the benefit derived from wedge resection in our cases was marked. Of the cases that were subsequently seen at follow-up, there was restoration of regular ovulatory menstrual flow in 83.3% and achievement of pregnancy in 33.3%. Hence, the observation that wedge resection is beneficial, and at times curative in polycystic ovarian disease seems to have a sound foundation.

Adult

Preterm and other babies with low birthweights in Ibadan.

Earlier studies on the incidence of low birthweight babies were unanimous in the belief that this is a peculiarity of the developing countries, especially of the negro race. However, the more recent studies have shown that the differences in the incidence of low birthweights between the developed and developing countries might be due to other factors. In a study of birthweights in Ibadan, Nigeria, evidence was presented which showed that the level of socio-economic standards, rather than the peculiarity of geographical location or race, accounted for a high percentage of low birthweight babies. The various other factors associated with low birthweight babies in Ibadan were also highlighted.

Female

Herpes type-2 virus antibody status in groups of patients with neoplasm in Ibadan.

Various studies have associated Herpes Type-2 (HT-2) virus with carcinoma of the cervix, especially the squamous cell type. In the present study, prevalence of HT-2 virus antibodies was found to be significantly higher in patients with squamous cell carcinoma of the cervix than in cases with squamous cell carcinoma of sites other than the cervix, and other pelvic and extrapelvic malignancies (P less than 0.001). It was concluded that no association could be found between Herpes Type-2 virus and malignancies of sites other than the cervix.

Antibodies, Viral

Herpes type-2 virus antigens in human cervical carcinoma.

Exfoliated cells from the cervices of 22 patients with histologically diagnosed squamous cell carcinoma of the cervix and from those of 24 control women were examined for herpes subtype 2 (HT-2) antigens by indirect immunofluorescence studies. This method demonstrated that cells from all the patients with carcinoma contained antigens related to HT-2 virus. In contrast, squamous cells from the cervices of 24 control women with no cervical disease and of 2 women with chronic cervicitis did not contain such HT-2 antigens. Although an etiologic role of HT-2 virus infection cannot yet be established, it is probable that such infection precedes neoplastic changes.

Adult

Antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in Ibadan, Nigeria.

Carcinoma of the cervix is by far the commonest gynecologic malignancy seen in Ibadan, Nigeria. In a study aimed at investigating the role of herpesvirus type 2 (HT-2) in its pathogenesis, antibodies to HT-2 were detected by immunofluorescence above a titer of 640 in 31 (70.5 percent) of 44 women with invasive carcinoma of the cervix as compared with five (11.1 percent) of 45 healthy women of the same age group. Analysis according to histologic types of growths showed that 31 (83.8 percent) of 37 cases of squamous-cell carcinoma had antibodies above a titer of 640, whereas none of the other types (one adenocarcinoma and six undifferentiated carcinoma of the cervix) had antibodies above this titer. It was concluded that the results of the present study support the hypothesis of an association between HT-2 and carcinoma of the cervix, most especially the squamous-cell type.

Antibodies, Neoplasm