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Biomedical subjects

B Alday

Publications and source records attributed to B Alday.

4 recordsLinked to original sources
PubMed1984

Heterotopic ossification and HLA antigens.

Thirty patients with neurogenic (nontraumatic) heterotopic ossification following spinal cord injury in 20 and head injury in 10, were comprehensively screened for HLA antigens. The frequencies of 68 HLA-A, -B and -C antigens were examined. The HLA-A2 locus was present in 18 patients (60%) as compared to the phenotypically adjusted normal of 48.4% and was not statistically significant at the 0.05 level. No statistically significant increased frequency of the HLS-B18 or HLA-B27 antigens was detected. A positive correlation does not exist between the HLA antigen system and patient susceptibility to heterotopic ossification following head injury or spinal cord injury.

Adult↗
PubMed1983

Diphosphonate treatment for heterotopic ossification in spinal cord injury patients.

Nine patients who had spinal cord injury and were receiving diphosphonate therapy for established neurogenic heterotopic ossification in 14 hips were followed up for an average of 14 months. Diphosphonate therapy at a dosage of 10 mg/kg/day when prescribed an average of 26 days after diagnosis did not prevent radiographically evident progression of heterotopic ossification. The interval of one to 30 days between clinical diagnosis and institution of diphosphonate treatment did not appear to affect the duration of radiographic progression or the final radiographic grade at maturity. Disodium etidronate therapy did not prevent the appearance of heterotopic ossification in three previously unaffected hips, although the final radiographic grade was mild. The radiographic progression of heterotopic ossification averaged 5.3 months. No clinically detectable side effects were attributable to the medication at the dosage prescribed after an average of 14 months of therapy. Due to the radiographic progression noted in patients who received 10 mg/kg/day, diphosphonate has been increased to dosages of 20 mg/kg for six months after early diagnosis.

Adolescent↗
PubMed1982

Hematologic features of chronic renal failure associated with spinal cord injury.

We examined the available hematologic data on 43 spinal cord injury (SCI) patients with end-stage renal disease (ESRD) treated with hemodialysis since 1972. A control group consisting of 45 ESRD patients without SCI was included for comparison. Moderate to severe anemia was found in all patients. The observed anemia was generally normocytic, normochromic, and associated with a low reticulocyte response. Transfusion requirement in the SCI group was considerably more than in the control group. There was a high incidence of splenomegaly, splenic amyloidosis, and lymph node enlargement in the SCI group. Lymph node and bone marrow amyloid deposits were found in some SCI patients but not in the control subjects.

Adult↗