PubMed Health⌕ Search

Biomedical subjects

B Ali

Publications and source records attributed to B Ali.

71 records · Page 4Linked to original sources
PubMed1976

Anticonvulsant activity and selective inhibition of nicotinamide adenine dinucleotide-dependent oxidations by 10-(2-arylimino-3-acetylamino-4-thiazolidonyl) phenothiazines.

Several Several 10-(1-acetyl-4-arylthiosemicarbazido) phenothiazines and their corresponding cyclized 10-(2-arylimino-3-acetylamino-4-thiazolidonyl)phenothiazines were synthetized and characterized by their sharp melting points and elemental analyses. All compounds inhibited nicotinamide adenine dinucleotide (NAD)-dependent oxidation of pyruvate and alpha-ketoglutarate selectively, whereas NAD-independent oxidation of succinate remained unaltered. All phenothiazine derivatives exhibited anticonvulsant activity, which was reflected by the 20-60% protection observed against pentylenetetrazol-induced convulsions in mice. The ability of substituted thiosemicarbazidophenothiazines to inhibit cellular respiratory activity was reduced considerably by cyclization to the corresponding substituted thiazolidinophenothiazines. On the other hand, cyclization generally resulted in increased anticonvulsant activity. Thus, the anticonvulsant activity possessed by these substituted phenothiazines bore no relationship with their ability to inhibit selectively the NAD-dependent oxidations. Selective inhibition of NAD-dependent oxidation of pyruvate and alpha-ketoglutarate in isolated rat brain mitochondria by some 10-(1-acetyl-4-arylthiosemicarbazido) phenothiazines was concentration dependent and competitive in nature.

Animals↗
PubMed1975

Antihemolytic and anticonvulsant activities of 1-(2,4-dichloro/2,4,5-trichlorophenoxyacetyl)-4-alkyl/arylthiosemicarbazides and their inhibition of NAD-dependent oxidations and monoamine oxidase.

Several 1-(2,4-dichloro and 2,4,5-trichlorophenoxyacetyl)-4-alkyl/arythiosemicarbazides were synthesized and characterized by their sharp melting points and elemental analyses. All substituted thiosemicarbazides protected in vitro hypoosmotic hemolysis of dog red blood cells. These thiosemicarbazides selectively inhibited nicotinamide adenine dinucleotide (NAD)-dependent oxidation of pyruvate and alpha-ketoglutarate, while NAD-independent oxidation of succinate was not affected. These compounds inhibited the activity of monamine oxidase in rat brain homogenate, and the degree of inhibition ranged from 26.5 to 89.2 percent at a final concentration of 0.03mM, with kynuramine as the substrate. Almost all thiosemicarbazides possessed anticonvulsant activity; protection against pentylenetetrazol-induced convulsions in mice ranged from 10 to 70 percent at a dose of 100 mg/kg ip. These results provided evidence of some similarity between the membrane-stabilizing property of these substituted thiosemicarbazides with their ability to exhibit selective inhibition of NAD-dependent oxidations and inhibition of monoamine oxidase. On the other hand, the anticonvulsant activity possessed by these substituted thiosemicarbazides was unrelated to their in vitro antihemolytic and enzyme inhibitory properties.

Animals↗
PubMedDate not supplied

The Barthel index in clinical practice: use on a rehabilitation ward for elderly people.

Primary activities of daily living (ADL) were monitored weekly in 102 patients admitted to a rehabilitation ward for elderly people using the Barthel index. The three commonest diagnoses were 'stroke', 'fractured neck of femur' and 'dementia recovering from acute illness'. Multiple disabling diagnoses were common: 60% of patients had dementia and 23% had a live-in carer; mean (median) length of stay in the rehabilitation ward was 98 (62 days). Over 18 months, the weekly assessment of patients in the ward was omitted once. No extra resources were needed. There was a significant rise in Barthel scores between admission to the rehabilitation ward (median Barthel 6) and discharge (median 13) for the group as a whole (median change 6, 95% CI 5-7; p < 0.001) and for each of the three main diagnostic groups. Barthel scores on discharge were significantly lower than in patients discharged from an acute ward for elderly people. Barthel scores and mental test scores (MTS) at discharge were significantly related to destination on discharge, with a characteristic pattern for patients unable to return home and having to be placed in nursing homes (Barthel < 10, MTS < 7). Our experience confirms that routine clinical use of the Barthel in this setting is feasible and responds to clinically important change, at least in group evaluation. It suggests that the Barthel may be useful in outcome measurement, case-mix adjustment and audit of discharge practices.

Activities of Daily Living↗