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Biomedical subjects

B Andreasson

Publications and source records attributed to B Andreasson.

49 records · Page 3Linked to original sources
PubMed1984

Diuresis and urine concentration during CPAP in newborn infants.

The impact of continuous positive airways pressure (CPAP) on diuresis and urine concentration was studied in newborn preterm infants with respiratory insufficiency with and without pulmonary X-ray changes. Urine output and osmolality, sodium balance and blood pressure were measured before, during and after CPAP application. In all infants urine osmolality rose and urine output decreased significantly when high CPAP (8 cm H2O) was applied, especially in infants without radiographic pulmonary changes. Three infants also developed hyponatremia at high CPAP levels. The results indicate that high CPAP levels per se may affect fluid balance inadvertently. Therefore fluid intake and urine output should be monitored closely during CPAP treatment.

Blood Pressure↗
PubMed1984

Pregnancy in Crohn's disease.

Over a 13-year period, the course of 109 pregnancies in 68 women with Crohn's disease was studied. A total of 76 children were delivered. There were no gemellary deliveries, and none of the children had congenital malformations. Pregnancy entailed no increased risk of an exacerbation of the bowel disease. As compared with the reference population and with women with ulcerative colitis, the total material showed an increased risk of premature delivery and spontaneous abortion, but a further analysis showed that this was due only to an increased risk in women with active disease at the time of conception and in women who had undergone bowel resection during pregnancy. Birth weight and birth length corresponded to those in the reference population. The frequency of neonatal hyperbilirubinaemia was not higher in children of mothers with Crohn's disease than in children of healthy mothers. Treatment with sulphasalazine, salazosulphadimidine, and corticosteroids did not influence the course of pregnancy or the frequency of neonatal jaundice or malformations. Consequently, in Crohn's disease a pregnant woman should be given the same medical treatment as when not pregnant. Generally, the women should be advised preferably to conceive at a time when their bowel disease is inactive. The risk groups should be followed up with frequent obstetrical examinations throughout pregnancy.

Abortion, Spontaneous↗
PubMed1983

Verrucous carcinoma of the vulval region.

Verrucous carcinoma is a variant of epidermoid carcinoma with distinctive clinical and pathological features. The diagnosis is often difficult. To date, 20 verrucous carcinomas involving the vulva have been reported in the literature. Metastases to the inguino-femoral lymph nodes have not been described. The treatment of choice is wide local excision. Clinical features, histological findings, and therapy are discussed.

Aged↗
PubMed1983

Pregnancy in ulcerative colitis.

The course of pregnancy in 97 women with ulcerative colitis was studied over a 12-year period. During this period they had 173 pregnancies and delivered 136 children. There were two gemellary deliveries. Nine women had a spontaneous and 16 an induced abortion, of which 4 were performed on therapeutic indication. For a woman with ulcerative colitis the risk of an exacerbation of the bowel disease was 32% per year in her fertile years, whereas it was 34% per year during pregnancy. This difference is not statistically significant. As compared with women with an inactive bowel disease, women in whom the disease was active at the start of pregnancy had a small but significantly greater risk of spontaneous abortion and premature delivery. The frequency of malformations, prematurity, and neonatal hyperbilirubinaemia was not higher in the children of ulcerative colitis mothers than in those of healthy mothers. Treatment with sulphasalazine, salazosulphadimidine, and corticosteroids had no influence on the course and outcome of pregnancy. Birth length and weight of the children of mothers with ulcerative colitis equalled those for children of healthy mothers. In conclusion, pregnancy does not necessitate any change in the usual medical treatment of ulcerative colitis. Women with ulcerative colitis should be advised preferably to conceive at a time when their bowel disease is inactive. Generally, ulcerative colitis constitutes no indication for induced abortion.

Abortion, Induced↗
PubMed1982

Invasive cancer in the vulvar region.

During the past 25 years there has been a tenfold increase in the incidence of vulvar cancer in Denmark. For this reason a material of 195 patients treated during the period 1960-77 is reviewed. There had been a considerable delay in treatment, due partly to the patients and partly to the doctor first seen. The five-year survival rate was 63.3%, corrected 84.2%. The prognosis is highly influenced by the size of the tumor, its appearance, the presence of unilateral or bilateral metastasization to the inguinal nodes, the histological type, and localization of the tumor. On the basis of these features, it is possible to single out groups having a particularly poor prognosis in whom the surgical treatment is insufficient and ought to be supplemented. Clinical assessment of the inguinal lymph nodes carries a considerable uncertainty, yet the FIGO staging is based mainly upon this assessment. This goes some way towards explaining why no prognostic differences were found between stages I, II, and III. Postoperative staging based upon the histological diagnosis would provide greater prognostic certainty.

Adult↗
PubMed1981

Influence of 2 mg estradiol-17 beta on circulating FSH, LH, total and unconjugated estradiol levels in post-menopausal women.

The 24-hour variation in total and unconjugated serum estradiol-17 beta as well as the daily variation in one-hour serum concentration values of FSH and LH have been examined in 9 post-menopausal women given 2 mg tablets of estradiol-17 beta daily for 14 days. The tablets were manufactured according to a new dispersion method aiming at producing essentially smaller crystals, thereby enhancing the bioavailability of the estradiol-17 beta. In comparison with other preparations, this one provides a more rapid absorption, reaching peak effect after only 1 or 2 hours and presenting a higher peak than has been found with any of the others. The elimination from serum combines a rapid initial phase followed by a very slow one. Thus serum levels of estradiol-17 beta 24 hours after administration are significantly higher than the levels measured before administration of the first tablet. A rather small but significant reduction in serum LH and FSH was observed on the third and subsequent treatment days.

Aged↗
PubMed1975

Neuroendocrine dysfunction in galactorrhea-amenorrhea after oral contraceptive use.

Nonpuerperal alactorrhea and amenorrhea have been reported following the use of oral contraceptives. Treatment of this condition with ergot alkaloids has proved to be of great therapeutic value. Pretreatment plasma hLH and hFSH concentrations in 13 women with postqill galactorrhea-amenorrhea (PPGA) were 6.6 plus or minus 0.6 (SE.) and 5.0 plus or minus 0.8 mlU/ml, respectively. The mean prolactin concentration was 80.7 plus or minus 13.2 ng/ml. After complete evaluation in which diagnostic evidence of pituitary tumor was absent, the patients were treated with ergocryptine (CB-154). The mean hPRL concentration at 14 days of therapy was 7.8 p;us or minus 1.9 ng/ml. Cyclic gonadotropin secretion resumed in all but one instance; ovulation was confirmed on the basis of a biphasic temperature chart and in 5 cases, endometrial biopsy. Measurement of serum dopamine-beta-hydroxylase (DBH) activity indicated a significant decline at the end of 8 weeks of CB-154 therapy. The fall in hPRL was not necessarily associated with a fall in DBH. The majority of women in this study exhibited a consistent personality suggesting varying degrees of anxiety unrelated to the PPGA and usually antedating the use of oral contraceptives. PPGA was found in women without hyperprolactinemia, but altered hPRL secretion was evident in all instances. The data suggest that the disorder of cyclic gonadotropin secretion is related to altered hPRL secretion, but the mechanism is possibly related to a catecholamine abnormality. The data support the presence of an inherent cyclic mechanism for the secretion of gonadotropins. CB-154 therapy does not affect conception, and no teratogenic effects were observed in 2 infants born to women who had received CB-154 during the first 40 days of gestation.

Abortion, Induced↗