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Biomedical subjects

B B Adams

Publications and source records attributed to B B Adams.

At least 19 recordsLinked to original sources

Immunofluorescence in dermatology.

The accurate diagnosis of bullous and other immune diseases of the skin requires evaluation of clinical, histologic, and immunofluorescence findings. Immunofluorescence testing is invaluable in confirming a diagnosis that is suspected by clinical or histologic examination. This is especially true in subepidermal bullous diseases that often have overlap in the clinical and histologic findings. Direct immunofluorescence is performed on perilesional skin for patients with bullous diseases and lesional skin for patients with connective tissue diseases and vasculitis.

Connective Tissue Diseases↗

A center's callosities.

We present a case report of a 14-year-old white male who developed hyperkeratotic plaques on the distal aspects of 2 toes. He was referred by his primary care physician for the treatment of onychomycosis. With questioning, the patient stated that he played center for his high school basketball team. After physical examination, he was diagnosed with callosities caused by his basketball activities. Proper nail hygiene and wearing of larger footwear resulted in improvement of his callosities. Sports-related cutaneous injuries should be included in the differential diagnosis of nail and toe abnormalities.

Adolescent↗

Annular lichen sclerosus et atrophicus.

Lichen sclerosus et atrophicus (LSA) is an idiopathic skin condition characterized by ivory-colored, atrophic papules and plaques. Many variants of LSA have been described. Only rarely has an annular variant been noted. We present a case of annular LSA and discuss the other reported cases exhibiting an annular shape.

Anal Canal↗

Water-slide alopecia.

A 29-year-old male presented with large, symmetric, alopecic patches on the posterolateral aspects of both calves. A detailed history revealed that the individual had recently attended a water-slide amusement park. Repeated frictional trauma between the legs and the slide resulted in these alopecic patches. Friction, especially when encountered during sports-related and recreational activities, should be included in the differential diagnosis of well-defined alopecic patches.

Adult↗

Sports dermatology.

Sports-related skin disorders are among the most common ailments affecting adolescent athletes and may significantly impact their performance and that of their team. These conditions may be due to infection, sun exposure, trauma, inflammation or chemical changes. Knowledge of the various disorders and their unique presentations are paramount to the caring for athletes. When making decisions regarding treatment, the clinician should consider the implications for both the individual athlete and the team.

Adolescent↗

Karate cicatrices.

A 46-year-old male presented with linear scars on the dorsal aspects of both hands. The lesions were caused by trauma occurring during the practice of karate. Sports-related scars should be included in the differential diagnosis of scars on the dorsal aspects of the hands.

Cicatrix↗

Sports dermatology.

Sports-related dermatoses are among the most common ailments affecting athletes, from the neophyte to the professional. The general types of skin conditions related to athletic activity include infections, aberrant growths, inflammatory reactions, traumatic conditions, and environment-related conditions. Knowledge of the skin disorders common to athletes and familiarity with the specific activities of each sport which place these athletes at greater risk are critical to making accurate clinical diagnoses, and educating athletes regarding treatment interventions and prevention.

Dermatitis↗

Acquired port-wine stains and antecedent trauma: case report and review of the literature.

BACKGROUND: While cases of congenital port-wine stains (PWSs) are relatively common, cases of acquired PWSs are quite rare. Many of the reported cases of the acquired type have been reported to be related to previous trauma. OBSERVATIONS: We encountered a case of acquired PWSs in a 3-year-old girl. Her parents noted that the lesions appeared in areas of antecedent trauma. This prompted us to review all reported cases of acquired PWSs and to assess the relationship to trauma. Among the 59 cases reported, there was a slight female predominance (female-male ratio, 35:24). Seventeen (29%) of the cases were related to trauma. One report evaluated the effectiveness of lasers in the treatment of acquired PWSs and found that 54% of patients treated with pulsed dye lasers had an excellent response or complete clearance. CONCLUSIONS: Port-wine stains are not only congenital but can be acquired as well. Trauma can be one of the causes of acquired PWSs. To explain this phenomenon, various theories, including abnormal vascular repair and altered vascular innervation, have been proposed. Lasers are the treatment of choice in all cases of PWSs and may be more effective in those that are acquired.

Child, Preschool↗

A practical guide for serologic evaluation of autoimmune connective tissue diseases.

UNLABELLED: Serologic testing is important in the evaluation of patients with autoimmune connective tissue diseases (CTD). There are many techniques. Each of the tests has different sensitivity and specificity with varying diagnostic value. These serologic tests detect antibodies to numerous cellular components. The diagnostic significance and specificity of each antibody vary. Choosing the appropriate test and understanding its clinical utility is an important aspect in the diagnostic evaluation of patients with CTD. (J Am Acad Dermatol 2000;42:159-74.) LEARNING OBJECTIVE: At the conclusion of this learning activity, participants should be familiar with the various serologic tests for CTD, should understand the associations of specific antibodies with individual CTD, and should identify the factors that influence the predictive value of these serologic tests.

Autoimmune Diseases↗

Tinea corporis gladiatorum: a cross-sectional study.

BACKGROUND: Tinea corporis gladiatorum has been an infrequently reported condition in the dermatological literature. Two previous reports have investigated wrestlers during recognized epidemics of tinea corporis gladiatorum, but no study has examined wrestlers to determine the point prevalence of tinea corporis gladiatorum in a team without a known epidemic. Furthermore, no comparative study exists. OBJECTIVE: The purpose of this article is to determine the prevalence of tinea corporis gladiatorum in high school wrestlers in comparison with high school indoor track athletes. METHODS: Members of both the high school wrestling and indoor track teams were examined for the presence of tinea corporis. Students with clinical lesions of tinea corporis were evaluated with potassium hydroxide examination. The prevalence of tinea corporis in each group was compared. RESULTS: Seven of the 29 high school wrestlers (24%) had lesions of tinea corporis. No members of the track team had evidence of tinea corporis. There was a statistical difference between the two groups (P =.005). CONCLUSION: Tinea corporis gladiatorum can be found quite frequently among high school wrestlers. Because infection with dermatophytes can disqualify a wrestler from competing in matches, vigilant surveillance and rapid initiation of therapy can reduce the suspension of a team's practice and competition.

Adolescent↗

Cicatricial pemphigoid diagnosed by the use of indirect immunofluorescence.

BACKGROUND: A thorough work-up is paramount in the accurate diagnosis of oral erosive diseases. OBJECTIVE: A case of pemphigoid with negative direct immunofluorescence but positive indirect immunofluorescence is presented. METHODS AND RESULTS: A 77-year-old man presented with erosions of the oral and glans mucosa and with esophageal stenosis. Histologic examination revealed nonspecific mucositis. Indirect immunofluorescence was characteristic of pemphigoid. CONCLUSION: This case illustrates the importance of performing a complete diagnostic work-up in the evaluation of patients with oral erosive disease.

Aged↗

Periorbital comedones and their relationship to pitch tar: a cross-sectional analysis and a review of the literature.

BACKGROUND: Comedones, often in a periorbital distribution, have been claimed to be associated with pitch tar. OBJECTIVE: This cross-sectional study compares the incidence of periorbital comedones between a group of individuals exposed to pitch tar and a control group. METHODS: The incidence of periorbital comedones was determined in workers (n = 55) at a tar distillation plant. A comparison group (n = 55) not exposed to pitch tar was also examined for the presence of facial comedones. The respective incidence rates were compared by using the Fisher exact test. RESULTS: Eighteen percent (10/55) of the study group and 4% (2/55) of the control group had periorbital comedones. The study group had a significantly greater incidence of periorbital comedones (P =.01). CONCLUSION: The incidence of periorbital comedones is significantly greater in individuals exposed to pitch tar. Further studies are needed to elucidate the potential relationship between pitch tar and periorbital comedones.

Acne Vulgaris↗

Myelodysplastic syndrome presenting as cutaneous purpura.

Myelodysplastic syndrome is a preleukemic, clonal disorder of the hematopoetic stem cell. Cutaneous manifestations include infections, vasculitis, neutrophilic dermatoses, and leukemia cutis. Senile purpura is a common condition occurring in elderly individuals who lack other systemic or hematologic diseases. We present a case of myelodysplastic syndrome in which cutaneous lesions resembling senile purpura were the initial clinical manifestation.

Aged↗

Adult onset verrucous epidermal nevus.

Epidermal nevi are hamartomas of the skin and have multiple clinical variants, including a verrucous type. Usually verrucous epidermal nevi present at an early age, are found on the lower extremities, have a female predominance, and are refractory to treatment. Only very rarely do verrucous epidermal nevi have an adult onset. We describe a 60-year-old woman with a 5-year history of multiple verrucous plaques on her face, scalp, and neck. Histologic examination revealed the characteristic findings of verrucous epidermal nevus. This is the oldest patient reported with an adult onset verrucous epidermal nevus.

Diagnosis, Differential↗