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Biomedical subjects

B B Baker

Publications and source records attributed to B B Baker.

At least 19 recordsLinked to original sources
PubMed1991

Fine structure of the human synovial lining cell in osteoarthritis: its prominent cytoskeleton.

The cytoskeleton of the human osteoarthritic synovial lining cell (SLC) consists of an extensive number of vimentin intermediate filaments (IFs) in addition to microfilaments and microtubules. The IFs are especially prevalent in the SLC processes, but are commonly seen in a paranuclear arrangement. Processes, ending in numerous microvilli and blebs, project into the joint space. Scanning electron microscopy (SEM) further reveals the processes that may parallel the synovium surface for a short distance. IFs extend to the termination of such Numerous pinocytotic vesicles and extensive rough endoplasmic reticulum (rER) are characteristic of the type B cells. Lysosomes and long microvilli identify the type A cell. Punctate adherens, gap junctions, and cilia are the cell membrane specializations of the osteoarthritis (OA) synovium. A comparison with synovium from rheumatoid arthritis (RA) patients is made in order to assess the effect o this inflammatory disease on the SLC cytoskeleton, cell type relationship, and cell arrangement. The prominent cytoskeleton appears to play an important role in the architecture of the synovium. Our findings are further presented in the form of a drawing which in some aspects could describe the morphology of the normal synovium.

Actin Cytoskeleton↗
PubMed1987

Formation of acute pulmonary toxicants following thermal degradation of perfluorinated polymers: evidence for a critical atmospheric reaction.

In some small-scale tests of combustion-product toxicity, perfluorinated polymers (FP) have been shown to be much more toxic than other common materials. These studies were conducted to determine the conditions under which highly toxic decomposition products of FP are formed. A modification of the National Bureau of Standards exposure system (Levin et al. National Bureau of Standards 1982, NBS IR 82-2532) was used, in which materials could be heated either in a cup furnace or above a small methane flame. At 700 degrees C, the approximate lethal concentrations (ALCs) of the products formed from polytetrafluoroethylene (pTFE) and from hexafluoropropylene/tetrafluoroethylene copolymer (FEP) in the CH4 flame (applied for 1 min) are approximately 850 times higher than the ALCs of the products formed in the cup furnace. Analytically, the major products formed initially from pTFE at 700 degrees C under either condition (flame or cup furnace) are similar but they disappear rapidly in the presence of continuous heat. When the cup furnace is removed 1 min after pTFE is added (a procedure temporally similar to the use of the flame) the toxicity of the products is again low. However, when heat from either the cup furnace or from a small secondary flame is applied continuously (for up to 30 min) to the initial products formed from pTFE in the flame, high toxicity is observed. These observations are supported by pathological evaluation of the respiratory tracts of exposed rats. Thus, the inhalation toxicity of FP thermal decomposition products is related to a heat- and time-dependent atmospheric reaction. Such mechanisms should be considered in estimating the fire hazard of these materials in use.

Animals↗
PubMed1987

Epidermal cell renewal in seborrheic skin of dogs.

Epidermal cell renewal time of seborrheic skin was estimated in 8 adult Cocker Spaniels and 5 adult Irish Setters, using autoradiography after [3H]thymidine was given intradermally. Cell renewal time of the viable epidermis was approximately 7 days. Seemingly, the seborrheic skin observed in these Cocker Spaniels and Irish Setters was associated with an altered rate of epidermal keratinization.

Animals↗
PubMed1977

Sudden deafness and facial palsy from metastatic bronchogenic carcinoma.

A 52-year-old man developed sudden total bilateral deafness, and unilateral facial palsy, without other symptoms and findings. He died two months later of of bronchogenic carcinoma metastatic to dura, brainstem, pons, carebellopontine angle, cerebellum and cranial nerves III, VI, VII and VIII. There was bilateral internal auditory canal erosion. Tumour replaced right facial, acoustic and vestibular nerves. Tumour infiltrated spiral ganglion, cochlear nerve, cochlear aqueduct, and destroyed nearly all facial nerve fibres to the level of the stapedius muscle. No tumour cells were found on the left, but few fibres of facial, acoustic and vestibular nerves survived. Both ears showed some cochlear outer hair cell destruction. Metastatic tumour to temporal bone or dura should be considered when loss of peripheral VIIth or VIIIth nerve function occurs.

Brain Neoplasms↗
PubMed1976

Evaluation of topical application of ronnel solution for generalized demodicosis in dogs.

Of 20 dogs with generalized demodicosis, 18 responded favorably to treatment with 8.5% ronnel solution applied to one-third of the body every 3rd day, in rotation. Duration of treatment was from 5 to 20 weeks. In 2 dogs, the demodicosis recurred and required additional treatment with ronnel. Two dogs died during the study. One death was attributed to ronnel toxicosis; the other was unexplained. Eight of 10 control dogs treated orally and topically for pyoderma associated with demodicosis still had demodicosis 1 year after initiation of the study.

Animals↗
PubMed1975

Nodular panniculitis in the dog.

Nodular panniculitis, a granulomatous inflammatory disease of the subcutaneous fat, was diagnosed in 11 dogs. Clinically, the disease was characterized by development of subcutaneous nodules and intermittent fever and anorexia. Short-term corticosteroid therapy was effective in 10 of the 11 dogs.

Animals↗
PubMed1975

Drug eruption in a dog.

Scaly, slightly erythematous dermatitis developed in a young adult Vizsla dog after parenteral administration of acepromazine. The dog recovered after treatment with water baths, but the dermatitis recurred 4 months later, again after parenteral administration of the tranquilizer.

Acepromazine↗
PubMed1975

Eversion of the laryngeal ventricle.

Eversion of the laryngeal ventricle is a rare lesion that presents with cough and/or voice changes. Laryngoscopy reveals a polypoid mass arising from the ventricle. Microscopically a polyp covered with ventricular mucosa and containing normal laryngeal mucous glands is seen. Chronic inflammation is usually present. Treatment in symptomatic cases consists of surgical removal endoscopically or by laryngofissure. The management of one patient is reported with a discussion of the cause, symptoms, and treatment of this condition.

Diagnosis, Differential↗
PubMed1975

Nevus sebaceous of Jadassohn.

The nevus sebaceous of Jadassohn is a little known entity to most otolaryngologists. Most of the reported cases have occurred on the face or scalp. The lesion is usually congenital. It is a hairless, yellowish-red plaque until puberty when it becomes verrucous and unsightly. Benign or malignant tumors frequently develop. Associated ocular and central nervous system defects are occasionally present. The treatment is full-thickness excision as early as is feasible for cosmetic purposes and to avert the potential development of benign or malignant tumors.

Humans↗
PubMed1975

Suppression of in vitro lymphocyte transformation by serum from dogs with generalized demodicosis.

Serum from dogs with generalized demodicosis suppressed the in vitro reactivity of peripheral lymphocytes to phytohemagglutinin. Suppression occurred with peripheral lymphocytes from normal dogs or from dogs with generalized demodicosis. Serums from dogs in remission were no longer suppressive. The data indicate that peripheral lymphoid cells obtained from dogs with generalized demodicosis do not respond differently in vitro to phytohemagglutinin than do lymphoid cells from normal dogs when either is cultured in the presence of serum from normal dogs.

Animals↗
PubMedDate not supplied

Cervical esophagostomy in dogs: endoscopic, radiographic, and histopathologic evaluation of esophagitis induced by feeding tubes.

Prolonged tube feeding is frequently necessary in patients with head and neck cancer, facial trauma, or central nervous system disease. The advantages of cervical esophagostomy over nasogastric and gastrostomy tube feeding are established. One frequently overlooked complication of tube feeding is distal esophagitis and subsequent stricture formation. This complication has been widely reported in the medical literature although the pathophysiologic mechanism has in part been speculative. We have completed a prospective, randomized, controlled animal study in an attempt to delineate the mechanism of feeding tube esophagitis and to devise a method of avoiding it. Twelve dogs underwent cervical esophagostomy and were studied by endoscopy, contrast fluoroscopy, gross and microscopic pathology. The esophageal effects of placement of polyethylene and silicone rubber esophagostomy tubes in the customary position, through the cardioesophageal junction into the stomach, were compared with placement of the distal end of the tube only as far as the midesophagus. Midesophageal placement of silicone rubber tubes greatly reduced esophageal injury inherent is esophagostomy tube feeding. A new esophagostomy feeding tube is presented with advantages over previously used tubes.

Animals↗