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Biomedical subjects

B B Floyd

Publications and source records attributed to B B Floyd.

4 recordsLinked to original sources
PubMed1985

Fibronectin in human trabecular drainage channels.

Fibronectin, an extracellular glycoprotein, has been shown to be produced by human trabecular cells in culture by our group as well as Polansky and co-investigators. Studies of Rodrigues et al suggested that fibronectin may be one of several glycoproteins found in increased amounts in the corneoscleral trabecular meshwork of glaucomatous eyes. The authors have developed a sensitive immunoassay utilizing avidin-biotinylated enzyme complex (ABC) to detect low levels of fibronectin in frozen sections of human eyes. The authors have used this immunoassay together with a perfusion technique to demonstrate distribution patterns of fibronectin present in human aqueous drainage channels. The authors found that fibronectin is present in larger quantities in the aqueous drainage channels than in the surrounding tissues in 18 eyes from older patients.

Aged↗
PubMed1983

Increased vascular permeability in disc swelling produced by ocular hypotony.

Chronic hypotony and swelling of the optic disc was produced in monkey eyes by ciliary body freezing. Associated changes in vascular permeability were detected with horseradish peroxidase (HRP) used as a marker of vascular integrity. Extravascular infiltration of HRP was seen in eyes with disc swelling in the lamina retinalis, lamina choroidalis, lamina scleralis and retrolaminar myelinated portion of the nerve head. In the anterior lamina retinalis, HRP was found in perivascular connective tissue and in interaxonal spaces around some vessels. Our findings suggest that the major source of extravascular HRP in the optic nerve head in disc swelling is leakage from the choriocapillaris through the perineural connective tissues, although focal leakage from vessels in the anterior portions of the swollen disc probably also occurs.

Animals↗
PubMed1982

Pseudorheumatoid nodule involving the orbit.

We report a clinicopathologic study of an unusual case of pseudorheumatoid nodule involving the right orbit of a child. Pathologically, the orbital lesion was similar to subcutanous nodules of rheumatoid arthritis and rheumatic fever. The physical findings and laboratory studies in our case did not reveal any evidence of systemic disease. Based on a review of reported cases involving other locations, this lesion appears clinically benign in children.

Child↗