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B B Gorzalka

Publications and source records attributed to B B Gorzalka.

89 records · Page 5Linked to original sources
PubMed1979

Isolation-induced facilitation of male sexual behavior in mice.

Sexual performance of male mice housed individually or in groups of 3 or 12 was compared. Experiment 1 examined naive males presented at weekly intervals with ovariectomized, estrogen-primed, progesterone-treated females. Performance in isolates was consistently superior and reached an asymptote that was twice that of grouped animals. Reversal of housing conditions reversed performance. Experiment 2 varied intervals of isolation among subjects, finding facilitation at several intervals. Experiment 3 compared animals under different population densities. Density did not alter the effects of isolation and grouping. In all experiments, additional tests with target males indicated that aggressive and sexual performance were moderately correlated and responded similarly to parametric manipulations. These results parallel and extend studies of isolation-induced aggression.

Aggression↗
PubMed1976

Effects of genotype on differential behavioral responsiveness to progesterone and 5alpha-dihdroprogesterone in mice.

Thirty female CD-1 mice, 30 female Swiss-Webster mice, 45 hybrid female mice of the strain SWCD1F1, AND 45 HYBRId female mice of the strain CD1SWF1 were ovariectomized and administered estradiol benzoate once weekly for 6 weeks. Estrogen injections were followed 2 days later by injections of progesterone, dihydroprogesterone (DHP), or oil and the animals were tested for receptivity 7 hr later. Over the six tests, there was a progressive increase in the frequency of lordosis responses in all strains following progesterone treatment. However, lordosis scores varied widely across animals within strains. Following DHP treatment, lordosis frequency was not increased in the Swiss-Webster strain. Females in the other strains did show a progressive increase in lordosis frequency over weeks. The data indicate that the hybrid strains develop the potential to respond to DHP and thus behave like the CD-1 strain, suggesting that sensitivity to DHP is a dominant trait.

20-alpha-Dihydroprogesterone↗
PubMedDate not supplied

Inhibition not facilitation of sexual behavior by PCPA.

It has been proposed that estrous behavior in the female rat may be under tonic inhibition by a central serotonergi system. Studies conbining estrogen priming and the pharmacological depletion of serotonin have provided some support for this hypothesis. Some evidence, however, is not consistent with this hypothesis. In the present study estrogen primed ovariectomized-adrenalectomized rats were administered p-chlorophenylalanine and were tested for lordosis behavior 66 and 70 hr later. Lordosis was not facilitated. The animals were then administered progesterone and retested at hour 74. PCPA inhibited progesterone-induced lordosis behavior in a dose dependent manner.

Adrenal Glands↗
PubMedDate not supplied

Short and long term inhibitory actions of alpha-melanocyte stimulating hormone on lordosis in rats.

The effects of 200 ng of intracerebroventricularly (ICV) and 20 micrograms of subcutaneously (SC) administered alpha-melanocyte stimulating hormone (MSH) on lordosis in rats were examined. Previous research, employing crossover designs, has revealed significant effects of MSH on lordosis. The results of Experiments 1a and 1b suggest that similar designs produce significant effects even in the absence of MSH. Thus, it is not clear that previous results were due exclusively to an action of MSH. Experiment 2 employed a modification of previous procedures and indicated that MSH administered either SC or ICV inhibited receptivity in subjects displaying high levels of responding. Moreover, MSH administered SC was also found to facilitate receptivity in subjects displaying low levels of responding. However, a possible long term inhibitory action of MSH on receptivity was also revealed. Because animals were tested repeatedly, this brought into question the results of Experiment 2. Procedures were revised accordingly and the effects of MSH re-examined. The results of Experiment 3 indicated that MSH administered SC facilitated receptivity while MSH administered ICV inhibited receptivity. In addition, MSH administered ICV exerted an inhibitory effect one week after administration. Therefore, MSH appears to exert both short and long-acting effects on sexual receptivity.

Animals↗
PubMedDate not supplied

Selective activation of opioid receptors differentially affects lordosis behavior in female rats.

The effects of opioid peptides that are highly selective ligands for mu receptors (morphiceptin). delta receptors (delta-receptor peptide), kappa receptors (dynorphin 1-9), and the mu/delta complex (beta-endorphin), were tested on lordosis behavior in ovariectomized rats primed with estrogen and progesterone. Intracerebroventricular infusions of beta-endorphin or morphiceptin both inhibited and facilitated lordosis in a dose-dependent fashion whereas all doses of delta-receptor peptide facilitated lordosis. Dynorphin 1-9 had no significant effect at any dose, although a trend toward increased lordosis quotients was observed 30 min after infusion. The effects of beta-endorphin, morphiceptin, and delta-receptor peptide were reversed with naloxone, although naloxone alone had no effect on lordosis behavior. These results indicate that the specific activation of opioid receptor subtypes differentially affects lordosis behavior. It appears that binding to high-affinity mu 1 receptors exerts an inhibitory influence on lordosis, whereas binding to low-affinity mu 2 receptors or delta receptors exerts a facilitatory influence. Binding to kappa receptors does not appear to affect lordosis behavior.

Angiotensin II↗
PubMedDate not supplied

Psychoactive drugs and human sexual behavior: the role of serotonergic activity.

A wide range of both prescription and nonprescription drugs has been reported to affect human sexual functioning. While the sexual side effects resulting from drug use have often been attributed to adrenergic, anticholinergic or dopaminergic activity, the present review considers the potential role of serotonin. Based on animal studies, serotonin has been shown to either facilitate or inhibit sexual activity depending on which serotonin receptor subtype is activated. However, few studies have been done in the human that assess the effects of drugs that bind selectively to serotonin receptors. Consequently, little is known about the role of serotonin in human sexual functioning. In this review, a wide range of drugs that affect both brain serotonergic systems and human sexual behavior is examined in an effort to determine the possible role of serotonin in human sexual behavior. A review of the literature is consistent with the hypothesis that the 5-HT1A and the 5-HT2 receptor subtypes play a facilitatory role in human sexual behavior. The evidence suggests that drugs that act as agonists on these receptor sites enhance sexual functioning in the human, while those that act as antagonists inhibit sexual functioning.

Animals↗
PubMedDate not supplied

Inhibition of subjective and physiological sexual arousal in women by clonidine.

OBJECTIVE: The present investigation was designed to provide the first empirical examination of the effects of clonidine, a selective alpha 2-adrenergic agonist, on sexual arousal in women with and without prior sympathetic nervous system [SNS] stimulation by exercise. The purpose was to help elucidate the influence of adrenergic mechanisms on sexual function in women. METHODS: Thirty sexually functional women participated in two experimental sessions in which subjective (self-report) and physiological (vaginal photoplethysmograph) sexual responses to erotic stimuli were measured after either clonidine (0.2 mg) or placebo administration in a randomized, double-blind, crossover protocol. Before viewing the experimental films, 15 subjects engaged in 20 minutes of intense exercise designed to elicit significant SNS activation. RESULTS: Clonidine significantly decreased vaginal pulse amplitude, vaginal blood volume, and subjective sexual responses to the erotic films in subjects who were in a state of heightened (via exercise), but not baseline (no exercise) SNS arousal. CONCLUSIONS: Clonidine can significantly inhibit subjective and physiological sexual arousal in women. These findings have implications for deriving an etiological theory of sexual function in women and for understanding the effects of psychotherapeutic drugs on female sexual function.

Adolescent↗