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B B Sheth

Publications and source records attributed to B B Sheth.

2 recordsLinked to original sources

Evaluation of adsorption from dispersion charge profile.

The evaluation of adsorption behavior from the charge profile of an adsorbent dispersion determined as a function of the adsorbate concentration was investigated by the streaming current measurement, using methylene blue and erythrosine as adsorbates and activated charcoal, microcrystalline cellulose, and polyvinylpolypyrrolidone as adsorbents. Adsorption capacity was evaluated using streaming current versus solute concentration plots of dye solutions and of corresponding dye solutions equilibrated with the adsorbent. It was also determined by adsorption isotherm measurement and application of the Langmuir equation. Good agreement was obtained between the adsorption capacity values from streaming current data and adsorption isotherm measurements for microcrystalline cellulose, suggesting that adsorption here was a surface phenomenon without water-soluble extractives affecting particle charge. Similar agreement was not obtained for charcoal adsorption, and this result was attributed to the unusual adsorption behavior of charcoal. Since polyvinylpolypyrrolidone gave a dispersion with high particle charge, the streaming current method could not be used with this system. The charge profile could be useful in characterizing powders for unusual adsorption behavior and possible water-soluble extractives as well as for surface area estimation in the absence of these factors.

Adsorption

Effect of polymers on dissolution from drug suspensions.

The effect of three viscosity grades of methylcellulose on the dissolution-dialysis rate of nitrofurantoin suspensions was investigated using a cell designed to provide a large surface area for dialysis. Apparent dialytic rate constants of drug dispersions and solutions were measured in 0.1 N HC1 and in pH 7.4 buffer. Samples containing methylcellulose had lower rates of dialysis, with the lowest rate being observed for samples in which the polymer was used as the suspending agent. The reduced rate of dialysis of the drug suspension containing methylcellulose is thought to be due to complexation of the drug in solution with the polymer as well as formation of microscopic regions of high viscosity surrounding the undissolved drug particles leading to a reduction in the dissolution rate of the drug. An empirical relationship was obtained to enable the estimation of the effective drug concentration in the dissolution chamber for drug dispersions. The method is based on utilizing dialysis rate data of drug solutions. This relationship could be used for comparing suspension formulations in terms of the amount of drug available for dialysis.

Chemistry, Pharmaceutical