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Biomedical subjects

B Bagni

Publications and source records attributed to B Bagni.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Circadian variations of plasma TSH in patients with severe hypothyroidism.

Five patients with severe hypothyroidism were studied to determine diurnal variations in serum TSH and thyroid hormones. The results were based on blood samples withdrawn at 1-h intervals during a 24-h period. A statistically significant circadian rhythm in TSH was detected with the acrophase at 23(30); no significant diurnal periodicity was observed for serum T3. The TSH pattern was similar to that observed in normal and midly hypothyroid subjects, with low levels during the day and higher levels at night. The findings are consistent with the following concepts: a. the TSH circadian rhythm is retained in patients with severe hypothyroidism; b. the abnormality in thyroid function does not effect the regulation of the TSH periodicity.

Adolescent↗
PubMedDate not supplied

Endocrine assessment of hypogonadism in patients affected by thalassaemia major.

Gonadotrophin releasing hormone (GRH) was administered to 54 patients (39 prepubertal and 15 pubertal) with beta-thalassaemia major to assess pituitary gonadotrophin secretory reserve. Human chorionic gonadotrophin (HCG) was also administered to 10 of the prepubertal boys to assess gonadal endocrine function. Many patients, some with and some without pubertal changes and including prepubertal children aged from 7 to 12 years, had evidence of pituitary hypofunction. A normal pituitary response to GRH stimulation, with decreased gonadal hormone response to the HCG test, found in 3 subjects, demonstrated that gonadal endocrine failure may also occur.

Adolescent↗
PubMedDate not supplied

Hypoparathyroidism in chronic alcohol intoxication: a preliminary report.

It is well known that osteoporosis is more common in chronic alcoholists than in age-matched controls. Possible aetiological factors could be: malabsorption of calcium and vitamin D, liver disease, abnormal parathyroid function. With this study, the authors investigated parathyroid hormone (PTH) behaviour in thirteen selected patients with alcohol abuse, free from any clinical or humoral sign of hepatopathy, and in ten healthy subjects as a control group. In alcohol abusers a significant reduction of plasmatic PTH, compared to normal calcium levels were found. A possible direct interaction effect between ethyl alcohol and PTH may be suggested, even if further studies are required.

Adult↗
PubMedDate not supplied

99mTc-MAG3 versus 131I-orthoiodohippurate in the routine determination of effective renal plasma flow.

99mTc-mercaptoacetyltriglycine (MAG3) has been proposed as an alternative to 131I-orthoiodohippurate (OIH) for the scintigraphic determination of effective renal plasma flow (ERPF). The purpose of this study was to compare the ERPF values determined simultaneously with MAG3 and OIH by a dual channel technique in a large group of subjects with widely ranging renal function. During the last two years, we administered a simultaneous injection of 74 MBq of MAG3 and 0.74 MBq of OIH to each subject who underwent a renal scintigraphic study in our hospital. They were 53 females and 50 males (mean age: 52 years; range: 18-70 years), either normal (30) or with a diagnosis of essential hypertension (53), chronic renal failure (14), renal calculi (5), or renal transplant (1). Plasma clearance and ERPF were calculated with both radiocompounds by using the exponential formula of Tauxe and coworkers and a single plasma concentration determination sampled 44 min after injection of the two tracers. The time-activity curves for kidney and blood were of the same bi-exponential type. The mean ratio between the two plasma clearances was 0.49. The linear regression of the ERPF values obtained with the two radiocompounds was highly significant (r = 0.69; p less than 0.0001) and is expressed by the equation: ERPF (MAG3) = 0.453 ERPF (OIH) + 25.7. These data suggest that the routine calculation of ERPF from MAG3 clearance is consistent with the results obtained from OIH clearance. In conclusion, MAG3 appears to be a good predictor of ERPF in routine clinical practice.

Adult↗