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Biomedical subjects

B Barr

Publications and source records attributed to B Barr.

At least 19 recordsLinked to original sources
PubMed1992

Direct measurement of oxygen free radicals following cardiac failure of ischemic dog myocardium with the electron spin resonance technique.

OBJECTIVE: To determine whether the involvement of oxygen-derived free radicals in the pathogenesis of ischemic cardiac failure in dogs. DESIGN: Free radicals were measured in normal and ischemic myocardium from dogs with cardiac failure induced by acute coronary occlusion. The changes in free radical production in ischemic myocardium (compared with normal myocardium with or without polymorphonuclear leukocytes) were studies, with plasma superoxide dismutase and malondialdehyde analyzed concurrently. MAIN RESULTS: The results showed that the oxygen free radicals in the ischemic myocardium were about 42.5% higher than those in the normal myocardium, about 67.8% higher than those in the normal myocardium washed with normal saline and about 60.5% higher than those in the ischemic myocardium washed with normal saline (P < 0.05). Compared with controls, the concentration of malondialdehyde in ischemic dog myocardium was increased markedly. The activity of plasma superoxide dismutase was not significantly different between control dogs and dogs with ischemic cardiac failure. CONCLUSIONS: The current results indicate that there was increased production of free radicals and peroxidative damage in ischemic myocardium of dogs with cardiac failure. Polymorphonuclear leukocytes appear to be a main source of free radicals in dog with ischemic cardiac failure.

Animals↗
PubMed1989

Herpes-like viral dermatitis in a beluga whale (Delphinapterus leucas).

Approximately 3.5 mo following its capture, a beluga whale (Delphinapterus leucas) developed focal pale gray skin lesions. These lesions persisted for at least 8 mo. A biopsy from one of these sites revealed epithelial intranuclear inclusions. Herpes-like viral particles were seen by transmission electron microscopy. The eventual regression of skin lesions and lack of other clinical signs suggests the virus was only mildly pathogenic in this animal.

Animals↗
PubMed1988

A longterm follow-up study of children born to women with contagious diseases at delivery.

Data are presented from a long-term follow-up study of 308 live born children to women admitted post partum to the Department of Infectious Diseases (DID), Danderyd Hospital, Sweden, during a 10-year period (1975-1984) for avoiding nosocomial transmission of infections in the obstetrical wards. The rate of stillbirths (1/309 deliveries) was not higher than reported for all births in Stockholm. 20% of the live born children were transferred within 24 h after birth to the pediatric department for observation, but half of them could return to their mothers at the DID within 6 days (generally 3 days). Four newborns were treated at an intensive care unit. Only 3 fatalities occurred, all of them among newborns to mothers with an overt infection at delivery. The fatality rate (1.8%) was significantly higher among the newborns of these mothers than normally (0.3%) noted among all children born in Stockholm county during the period studied. Two of the 3 newborns, who all died within 3 days of life, had a low birth weight (600 and 1,000 g). The total number of newborns with low birth weights (less than 2,500 g) was, however, not higher in the above-mentioned group of newborns than for all children born in Stockholm county 1980. None of the 3 fatalities was caused by infection transmitted from the mother. No further deaths occurred. Infections in pregnancy at term, at birth or post partum were transmitted from the women to 41 (13%) of their newborns.(ABSTRACT TRUNCATED AT 250 WORDS)

Bacterial Infections↗