PubMed Health⌕ Search

Biomedical subjects

B Basse-Cathalinat

Publications and source records attributed to B Basse-Cathalinat.

17 recordsLinked to original sources
PubMed1991

Rationale for the design of biomaterials and the evaluation of their biocompatibility.

The biocompatibility of a material can be considered as the ideally expectable result of its interactions with living tissues with which it is interfaced. This property determines the ability of devices involving this material in their constitution, to correctly assume their ascribed function; reciprocally a bad fitting, between devices and their intended use, coming from a non-optimized design or from an inappropriate prescription, may alter the original biocompatibility of constitutive materials. Accordingly, the actual biocompatibility of a biomaterial depends upon both its intrinsic properties and the application in which it is involved. Such considerations must be taken into account by specialists who try to design more performant biomaterials, or new assist devices, should they be implantable or not; but they draw also methodological guidelines for the evaluation of the biocompatibility of these biomedical products.

Biocompatible Materials↗
PubMed1989

Biocompatibility of carbon-carbon materials: blood tolerability.

Carbon-carbon composites are well known in the field of aerospace technology. Such composites have been proposed to be used as biomaterials, particularly in contact with blood. To evaluate their haemocompatibility, samples were tested in vivo and in vitro, using radiotracers. In vivo study showed the accumulation of platelets on the exposed surface material with any surface morphology, whereas platelet concentration in blood remained constant. In vitro study allowed us to distinguish, among entrapped platelets, active adhering platelets from those mechanically retained and it appeared that the bulk structure of materials influenced the adhesion mechanism of platelets.

Animals↗
PubMed1989

Experimental evaluation of a gelatin-coated polyester graft used as an arterial substitute.

Protein coating and endothelial cell preseeding have been proposed and studied as improvements to arterial prostheses. In this paper, an impervious polyester vascular graft which had been coated with cross-linked gelatin was compared to a porous one over a period of up to 8 months in dogs. This evaluation involved in vivo methods using radio tracers to study patency and thrombogenicity and in vitro controls of the healing processes. The main advantages offered by coated grafts over uncoated include the absence of preclotting and better biointegration.

Animals↗
PubMed1986

Topographic and dynamic radioisotopic investigations of interactions between biomaterials and blood components.

Functional investigations using radionuclides to study protein adsorption and platelet adhesion onto biomaterials are described. The authors' novel methods use radiotracers with a dynamic technique. This allows direct observation of the interaction between blood, or simpler biological substances, and artificial materials. Several radiotracers were used in this study, including 111In-platelets, 123I-fibrinogen, 123I-antithrombin III, and 99mTc-tagged red blood cells. The detectors employed were a semiconductor diode or gamma-camera equipped with special collimators. The acquisition and treatment of data were performed with an original device. These methods allowed precise comparisons, especially between platelet adhesion upon different materials in the form of tubes and also protein adsorption and desorption. The results are discussed in terms of materials to be used for work in vivo.

Adsorption↗
PubMed1985

Visualisation of a thyroglossal duct.

After ablation of an autonomously functioning thyroid nodule resulting from an adenoma, a previously suppressed scintigraphic image of a thyroglossal duct was visualised.

Adenoma↗
PubMed1985

Hepatic blood flow in rats with portal branch ligation.

Hepatic arterial blood flow (HABF) in the liver lobes and splanchnic nonhepatic arterial blood flow were measured in rats with and without right portal branch ligation for 1 month using 57Co microspheres. Portal branch ligation led to 60% atrophy of the ligated lobe and to hypertrophy of the nonligated lobe. In nonligated lobes of the portal branch ligation model and in the lobes of controls, HABF expressed per gram liver was comparable. In both models splanchnic non-HABF was also comparable. In the atrophic lobe, HABF remained constant; expressed per gram liver, it increased. In this lobe the net result was a significant decrease in total hepatic blood flow (ml/min/g liver).

Animals↗
PubMed1985

[Study of the muscular perfusion of the lower limbs using thallium 201 scintigraphy before and after lumbar sympathectomy in 13 patients].

Scintigraphy with 201-Thallium is a useful method for exploring muscle circulation in lower limbs of patients with arteritis. Comparative values with time can be obtained by studying respective isotopic activity ratios of the thigh, calf and foot. Unilateral isolated lumbar sympathectomy was performed in 13 patients for arteriopathy of the lower limbs (7 claudications, 4 isolated trophic disorders, 1 thrash-foot and 1 juvenile arteriopathy). Investigations included clinical and arteriographic explorations and functional tests (Doppler, distal pressure, digital plethysmography and 201-Thallium muscle scintigraphy) before and after operation. Pathology of the sympathetic chain was determined in each case. Short-term (2 weeks) follow up examinations gave data showing absence of correlation between the operative procedure and scintigraphy results. Muscle perfusion was improved in only 3 cases: one presented paradoxical improvement contralateral to the sympathectomy, while no change from the pre-operative values was recorded in 9 patients. The findings raise questions concerning the reproducibility of the scintigraphic method, and also confirm the pathogenic hypothesis by which lumbar sympathectomy has only a limited effect on muscle circulation.

Arteriosclerosis↗
PubMed1977

[Isotopic criteria for the assessment of the effects of lumbar sympathectomy (author's transl)].

The authors present a work intended to assess the effects of lumbar sympathectomy using radioactive microspheres. These contain 99mTe and are injected into the femoral artery. The distribution of radioactivity is then measured at the lower limb with a gamma camera linked to a computer. Seventeen patients were tested before and after lumbar sympathectomy. It appears from this short series that lumbar sympathectomy causes a redistribution of the radioactive material directed towards the extremities, mainly the feet.

Aged↗
PubMed1975

[Application of correspondance factor analysis to function testing of the thyroid].

Biological data concerning 249 thyroid patients have been treated by using correspondance factor analysis. This statistical treatment has enabled us to compare 2 types of associated tests (in vitro, in vivo) and to evaluate their respective contribution to the diagnosis of different thyroid diseases. There appeared also certain possibilities for the use of such a method in the future: determination of a biological profile for thyroid disease and for Grave's disease patients in course of treatment.

Binding, Competitive↗
PubMedDate not supplied

[Xenon 133 pulmonary scintigraphy. Its significance in the preoperative evaluation of pulmonary function in adolescents with kyphoscoliosis prior to vertebral arthrodesis].

The pulmonary scintigraphy with xenon 133. On its interest in the pre-operative exploration of the kyphoscoliotic youth's lung function before vertebral arthrodesis. The classical functional lung exploration (spirometry, arterial blood gas) gives only a general aspect of the pulmonary function. On the other hand, the pulmonary scintigraphy with Xe 133 studying perfusion as well as ventilation gives into evidence some troubles concerning the distribution of the regional lung volumes together with a general or local increase of the lung on the scoliotic convex side; the base of the latter, whose volume is more important, is the seat of a physiological dead space. The lung on the scoliotic concave side shows a proportional reduction of perfusion and ventilation. We consider this investigation, harmlessly and easily carried out, as essential to observe the evolution of the young scoliotic patients' lung function.

Adolescent↗