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Biomedical subjects

B Bazelly

Publications and source records attributed to B Bazelly.

At least 19 recordsLinked to original sources
PubMed2006

[Spontaneous hemothorax: a rare but serious complication of intralobular pulmonary sequestration].

Pulmonary sequestration is a rare congenital malformation characterized by a non-functional portion of pulmonary parenchyma devoid of any connection with the bronchial tree and pulmonary artery. If not identified antenatally or at birth, the sequestration may not be discovered until complications, mainly repeated infections, arise. Hemorrhage is another but much rarer complication which is generally severe. We report a new case of intralobular pulmonary sequestration revealed by hemoptysis then massive hemothroax with shock requiring emergency thoracotomy for hemostasis.

Adult↗
PubMed2005

[Left strangulated diaphragmatic hernia: an unusual complication of gastric bypass].

The appearance of left strangulated diaphragmatic hernia doesn't seem to have been described in the past as a progressive complication after gastric bypass surgery. The authors describe the case of a 54 year old patient suffering from a strangulated gastric hernia pushing through a diaphragm defect located next to the gastric band. The gastric band had been placed two years previously in this patient suffering from morbid obesity. Strangulation of the hernia resulted in the sphacelation of the entire stomach fundus. Therefore a partial gastrectomy and removal of the band was necessary. Recovery from procedure was without complications. The past history of a major spinal trauma in this patient, could have led to a discussion regarding the etiology of this hernia, however the delay between the two events (28 years) makes this unlikely. It seems, therefore, that the placement of a gastric band was the responsible factor. The authors emphasize the importance of pre-procedure pulmonary X-ray, prior to any general anesthesia, as well as a post procedure cliché following any intervention that might have lead to diaphragmatic lesion.

Gastric Bypass↗
PubMed2004

[An exceptional but serious complication of benign intercostal schwannoma: hemothorax].

Spontaneous serious hemothorax has not been described previously as an inaugural signor secondary complication of benign intercostal schwannoma. We report a case in a 45-year-old woman who was hospitalized in an emergency setting after development of massive left hemothorax. After evacuation of the effusion, imaging demonstrated a voluminous apparently neurogenic tumor in an intercostal position. Thoracotomy was required for hemostasis due to persistent bleeding. Tumor resection was performed. At histology, the surgical specimen was found to be a benign schwannoma presenting hemorrhagic remodeling. Resection provided complete cure with no sequelae. This secondary complication favors resection of benign intercostal schwannoma.

Female↗
PubMed2003

[Moderately abundant hemoptysis revealing endobronchial hamartochondroma].

Hemoptysis is rarely the inaugural sign of endobronchial hamartoma. Abundance may range from moderate to massive, and may be life-threatening. We report the case of a 44-year-old woman who was referred to our center with moderate and persistent hemoptysis. A left upper lobe lobectomy was performed. We discuss the therapeutic options in such cases.

Adult↗
PubMed2003

[Intrapulmonary rupture of a dermoid cyst: MRI findings].

We report a case of dermoid cyst of the mediastinum ruptured into the lung. Only a few reports of ruptured mediastinal dermoid cyst have appeared in the literature. A 18-year-old female patient developed a tumor in the anterior mediastinum, which was coincidentally detected by a conventional chest X-ray. CT and MRI demonstrated two components: a cystic mediastinal mass and adjacent parenchymatous condensation. The cystic mass (no enhancement during or after injection) had a fatty structure: high-intensity T1 signal and low-intensity T2 signal. The thin wall (low-intensity signal on T1 and T2) was strongly enhanced during the systemic time and was ruptured. The parenchymatous condensation included a fatty effusion and an inflammatory reaction with the same T1 signal as the cyst, remaining slightly hyperintense on T2 with enhancement after injection. Cine-MRI demonstrated that the mass and the compressed right atrium were independent.

Adolescent↗
PubMed2002

[Retrotracheal cystic mass in the mediastinum].

We describe a case of retro-tracheal mass of the visceral compartment of the mediastinun in a 79-year-old woman revealed by signs of tracheal compression. Visualization of a vascular image coming from the cervical zone on reconstructed injected CT, and biological demonstration of a primary hyperparathyroidism led to the diagnosis of ectopic parathyroid adenoma, in spite of the cystic aspect of that tissular mass. Surgery by cervical approach was able to remove this mass without any problem. Pathological examination confirmed that it was a parathyroid adenoma with necrotic modifications. Follow up show a clinical and a biological improvement.

Adenoma↗
PubMed2001

[Standards, options and recommendations for the management of locally advanced non small cell lung carcinoma].

CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of the French Cancer Centres (FNCLCC), the 20 French Cancer Centres and specialists from French Public Universities, General Hospitals and Private Clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and outcome for cancer patients. The methodology is based on literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. OBJECTIVES: To develop clinical practice guidelines according to the definitions of the Standards, Options and Recommendations project for the management of locally advanced non small cell lung carcinoma. METHODS: Data were identified by searching Medline and the personal reference lists of members of the expert groups. Once the guidelines were defined, the document was submitted for review to independent reviewers and to the medical committees of the 20 French Cancer Centres. RESULTS: The main recommendations are: 1) The management of the locally advanced non small cell lung carcinoma has two main goals: firstly to obtain local control of the disease (or to at least delay local progression in order to improve the survival or relapse free survival), and secondly to prevent the development of metastases. 2) There is a consensus that locally advanced non small cell lung carcinoma should be irradiated. External beam radiotherapy should be of optimal quality and delivered at a minimal dose of 60 Gy by standard fractionation. For patients with a poor life expectancy, this can be delivered as a split-course or hypofractionated scheme. 3) Treatment for patients with a performance status of 0-1 should consist of short duration induction chemotherapy (with a least two drugs one of which must be cisplatin), combined sequentially with conventional radiotherapy. 4) Surgery is contraindicated in extensive N3 disease. Combined radio-chemotherapy (adjuvant or neoadjuvant) is not indicated outside clinical trials. Surgery is justified in stage N2 disease as good local control can be achieved. T4-N0 disease should be treated surgically with curative intent.

Adult↗
PubMed2001

[Standards, Options and Recommendations for the management of stage I or II primary bronchial cancers treated exclusively with radiotherapy].

CONTEXT: The 'Standards, Options and Recommendations' (SOR) project, started in 1993, is a collaboration between the Federation of the French Cancer Centres (FNCLCC), the 20 French cancer centres and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and outcome for cancer patients. The methodology is based on literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. OBJECTIVES: To develop clinical practice guidelines according to the definitions of the Standards, Options and Recommendations project for the management of stage I and II non small cell lung carcinoma treated by radiotherapy alone. METHODS: Data were identified by searching Medline and personal reference lists of members of the expert groups. Once the guidelines were defined, the document was submitted for review to independent reviewers, and to the medical committees of the 20 French cancer centres. RESULTS: The main recommendations for the management of stage I and II non small cell lung carcinoma treated by radiotherapy alone are: 1) The curative external irradiation with a continual course is an alternative to surgery only in the case of medically inoperable tumors or because the patient refuses surgery; 2) The external irradiation of the primary tumor only without the mediastinum could be proposed in peripheral stage IA. In proximal stage IA and IB, external irradiation should be carried out only as part of prospective randomised controlled trials comparing a localised irradiation of the primary tumor with a large irradiation of the mediastinum and the primary tumor. The treated volume must include the macroscopic tumoral volume with or without the microscopic tumoral volume and with a security margin from 1.5 to 2 cm; 3) There is a benefit to delivering a total dose in the primary tumor higher than 60 Gy in so far as the proposed irradiation, taking into account the respiratory function, does not increase the likelihood of severe adverse events due to radiation; and 4) The change in fractionation, the radiochemotherapy combination, the endobronchial brachytherapy with high dose rate alone or with external irradiation could be proposed only as part of prospective controlled trials for tumors classified as stage IB or II.

Aged↗
PubMed2000

Pulmonary complications following lung resection: a comprehensive analysis of incidence and possible risk factors.

STUDY OBJECTIVES: To assess the incidence and clinical implications of postoperative pulmonary complications (PPCs) after lung resection, and to identify possible associated risk factors. DESIGN: Retrospective study. SETTING: An 885-bed teaching hospital. PATIENTS AND METHODS: We reviewed all patients undergoing lung resection during a 3-year period. The following information was recorded: preoperative assessment (including pulmonary function tests), clinical parameters, and intraoperative and postoperative events. Pulmonary complications were noted according to a precise definition. The risk of PPCs associated with selected factors was evaluated using multiple logistic regression analysis to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Two hundred sixty-six patients were studied (87 after pneumonectomy, 142 after lobectomy, and 37 after wedge resection). Sixty-eight patients (25%) experienced PPCs, and 20 patients (7.5%) died during the 30 days following the surgical procedure. An American Society of Anesthesiology (ASA) score > or= 3 (OR, 2.11; 95% CI, 1.07 to 4.16; p < 0.02), an operating time > 80 min (OR, 2.08; 95% CI, 1.09 to 3.97; p < 0.02), and the need for postoperative mechanical ventilation > 48 min (OR, 1.96; 95% CI, 1.02 to 3.75; p < 0.04) were independent factors associated with the development of PPCs, which was, in turn, associated with an increased mortality rate and the length of ICU or surgical ward stay. CONCLUSIONS: Our results confirm the relevance of the ASA score in a selected population and stress the importance of the length of the surgical procedure and the need for postoperative mechanical ventilation in the development of PPCs. In addition, preoperative pulmonary function tests do not appear to contribute to the identification of high-risk patients.

Bronchial Fistula↗
PubMed2000

[Factors favoring the choice of classical surgery for the treatment of recurrent idiopathic pneumothorax].

We report 3 cases of recurrent idiopathic pneumothorax treated first by video-surgery then by classical surgery. These cases illustrate the difference in hospital stay and patient satisfaction, which is not always in favor of video-surgery. We also examine our personal experience with a series of 480 cases of pneumothorax treated by surgery, reporting the length of hospital stays and work stoppage. Delays were short with classical surgery and the recurrence rate was very low. In our opinion, the low cost and low rate of re-operations warrants the use of classical surgery.

Adult↗
PubMed1998

[Cystic opacity of the posterior mediastinum].

A patient with atypical clinical signs had a thoracic schwannoma in the left paravertebral gutter. Rigorous analysis of the standard x-rays, computed tomography examination and magnetic resonance imaging gave the diagnosis and guided surgical resection. The pathology report confirmed the imaging findings.

Humans↗
PubMed1998

[Acute respiratory insufficiency in patients with bronchopulmonary cancer].

Acute respiratory failure is relatively frequent in patients with bronchogenic cancer. The respiratory disorder may be related to tumor extension itself or opportunistic infection above or below the tumoral stenosis. Radiotherapy and chemotherapy can also be causal. The condition is particularly serious in patients with one lung. We discuss the different complications, their frequency and conditions of occurrence.

Acute Disease↗
PubMed1996

Indirect muscarinic receptor activation by pentamidine on airway smooth muscle.

1. Pentamidine is routinely used to reduce the incidence of Pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus, but it has been described as inducing pulmonary adverse effects, such as cough and bronchospasm. 2. In this paper we have investigated the effects of pentamidine on guinea-pig isolated main bronchi and human isolated bronchi. Pentamidine induced a concentration-dependent contraction in both preparations with pD2 values of 9.64 +/- 0.07 (n = 8) and 9.73 +/- 0.06 (n = 8) and a maximal effect (Emax) of 40 +/- 4% and 34 +/- 5% of the response to acetylcholine (1 mM) in guinea-pig and human bronchi respectively. Atropine (0.01 to 0.1 microM) and the muscarinic M3 receptor antagonist, hexahydro-siladiphenidol (0.1 and 1 microM) inhibited pentamidine-induced concentration-responses in both preparations in a non-competitive manner, whereas only high concentrations of the M1 receptor antagonist pirenzipine (1 microM) inhibited pentamidine concentration-response curves. 3. The cholinesterase inhibitor, tacrine (1 microM), potentiated the effect of pentamidine; in contrast, morphine inhibited pentamidine-induced responses. 4. The bronchoconstrictor effect of pentamidine on guinea-pig and human isolated bronchi was not modified by the H1 histamine receptor antagonist, mepyramine, by indomethacin or by the neurokinin NK1 and NK2 receptor antagonists, CP-96,345 and SR 48969 respectively, suggesting that neither histamine receptor stimulation, arachidonic acid derivative formation, nor tachykinin release are involved in pentamidine-induced contraction of human and guinea-pig airways. 5. Our overall results suggest that pentamidine induces contraction of guinea-pig and human isolated bronchi through prejunctional cholinergic nerve stimulation.

Adult↗
PubMed1996

[Postpneumonectomy pulmonary edema. Review of the literature. Apropos of 2 new cases].

Postpneumonectomy pulmonary edema is a poorly understood clinical entity. We report two new cases and review the literature. The main manifestations are increased pulmonary perfusion flow, endothelial damage, and amputation of the lymphatic system. Treatment depends on the physiological situation of the lung remaining after pneumonectomy. Prevention requires co-operation between the medical and surgical teams.

Humans↗