PubMed Health⌕ Search

Biomedical subjects

B Belden

Publications and source records attributed to B Belden.

4 recordsLinked to original sources
PubMed1999

Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy.

A retrospective review of 34 infants who started long-term peritoneal dialysis at </=3 months of age was conducted. Six of the patients died during infancy, leaving 28 infants who survived >1 year and who underwent a formal neurodevelopmental evaluation. In addition to dialysis, treatment of the patients included the use of calcium carbonate as the sole phosphate binder in all patients and supplemental nasogastric tube feeding in 27. At 1 year of age, the 28 patients had a mean head circumference standard deviation score of -0.96+/-1.2. The mental developmental score of 22 (79%) patients fell in the average range, while only 1 (4%) child was significantly delayed. Of 19 children retested at >/=4 years of age, 15 (79%) performed in the average range and 1 (5%) performed in the impaired range. Of 16 patients >/=5 years of age, 15 (94%) attended school full time and in age-appropriate classrooms. Twenty-four patients received their initial kidney transplant at a mean age of 2.1+/-0.8 years. This experience provides evidence that the combination of aggressive nutrition, the elimination of aluminum as a phosphate binder, the provision of dialysis, and subsequent transplantation all contribute to a favorable developmental outcome in infants who develop end-stage renal disease in early infancy.

Child Development↗
PubMed1999

Does perinatal phenobarbital exposure affect developmental outcome at age 2?

The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years. Between 1991 and 1994, 401 pregnant patients at risk for delivery prior to 34 weeks' gestation were invited to participate; 48 mothers declined entry. Before delivery, pharmacy randomized the pregnant women to receive phenobarbital and vitamin K or identically appearing placebo in a blinded fashion. Developmental follow-up at age 2 years was performed. Children from the treatment group scored significantly lower on the Bayley Mental Developmental Index (mean MDI +/- 1 SD) than children whose mothers were randomized to the placebo group [104 +/- 21 (n = 59) vs. 113 +/- 22 (n = 62), p = 0.023]. Of 36 independent variables, randomization group was one of five that individually contributed to the prediction of the Bayley MDI score (p < 0.05). It was concluded that perinatal phenobarbital therapy may impair developmental outcome.

Adult↗
PubMed1990

Nutritional and behavioural aspects of nasogastric tube feeding in infants receiving chronic peritoneal dialysis.

Eight infants initiated chronic peritoneal dialysis and received nasogastric tube feedings during their first month of life. In each case, the nasogastric tube feedings were initiated because of poor oral intake and the desire to avert the development of an aversive feeding interaction between parent and child. The nutritional regimen was designed to allow normal or catch up weight gain appropriate for height age. The caloric and protein intake of the infants averaged 98.5 +/- 10.2 kcal/kg/day and 2.7 gm/kg/day, respectively, during the first year of life. Between 25% and 100% of the formula intake was provided by the nasogastric route. Group standard deviation score for height was -1.74 +/- 0.7 at one year. Five of the infants received behavioral therapy because of persistent food refusal. Therapy consisted of reinforcing prompted food acceptance and ignoring food refusal. This approach was conducted by a multidisciplinary team and successfully converted the non-oral feeder to a total oral feeding regimen in each case.

Enteral Nutrition↗