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Biomedical subjects

B Bentley-Phillips

Publications and source records attributed to B Bentley-Phillips.

At least 19 recordsLinked to original sources

Hydroquinone.

Explore the source record for details and available documents.

Humans

The treatment of onychomycosis with miconazole tincture.

Treatment of onychomycosis is usually unsatisfactory. A small clinical trial using a solution of miconazole (Daktarin; Janssen) in alcohol was undertaken to assess its potential in this difficult condition. Ten unselected patients completed the 32-week trial and the results, irrespective of whether the infecting organism was fungal or monilial, are recorded. A much larger and controlled trial is essential before firm conclusions may be drawn, but the results, particularly in Candida infections, are encouraging.

Administration, Topical

Hereditary hypotrichosis. A previously undescribed syndrome.

A syndrome of hereditary hypotrichosis with an unusual natural history and clinical features was encountered in a Caucasian family of four generations with a total of twenty-four members of whom eleven were affected. The mode of inheritance was autosomal dominant with variable penetrance. The loss of hair involved the scalp, eyebrows, eyelashes and body hair, manifesting itself in the school years and progressing to almost complete baldness. There were no associated abnormalities and no sex limitation. Clinical, genetic, biochemical, mechanical, histological and immunological aspects were studied. Essential differences between this type of hereditary hypotrichosis and others previously recorded are stressed.

Adult

Cutaneous reactions to topical application of hydroquinone. Results of a 6-year investigation.

The investigation was designed to assess the safety of hydroquinone in cosmetic skin-lightening products, and to determine the optimal concentration for the purpose. The 840 volunteers who took part in the 6-year trial were drawn from various race groups with skins varying from very fair to very dark. They were subjected to open tests, "normal usage" tests, and standard 48-hour closed-patch tests. In all, over 7,000 test areas were examined. The results show that concentrations of hydroquinone of 3% and less produced negligible adverse effects, irrespective of the base or the colour of the user's skin. It is stressed that any confusion of hydroquinone with the hazardous monobenzyl ether of of hydroquinone (monobenzone, MBH) should be avoided.

Administration, Topical