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Biomedical subjects

B Berde

Publications and source records attributed to B Berde.

At least 19 recordsLinked to original sources

Physicians as employees of the pharmaceutical industry.

It is evident that a knowledge of medicine is indispensable for the discovery, development and, indeed, for the marketing of medicines. That is why the pharmaceutical industry has to employ physicians in research and marketing. However, this group of employees has always presented special problems. What I have to say relates to physicians, i.e. doctors who have trained as clinicians and who, initially at least, were drawn to clinical medicine. My remarks do not apply to pharmacologists, toxicologists and biochemists, i.e. natural scientists, who may have pursued their basic studies in a medical faculty and obtained a degree in medicine.

Drug Industry↗

[Importance of chemical mediators for the pathogenesis and treatment of hemicrania].

The vascular mechanism of migraine attacks--intracranial vasoconstriction during the prodromal stage and passive vasodilatation of extracranial arteries during the painful phase--has been confirmed by modern methods. In addition, number of humoral factors--plasmakinin, serotonin, histamine--intervene in the chain of events that culminates in migraine headache. In addition to these three humoral mediators, the part played by tyramine in migraine of alimentary origin, the precipitating effect of oestrogen decrease in menstrual migraine and the hypothetical role of prostaglandins and prolactin are discussed. The multifactorial mechanism of migraine accounts for the very variable profiles of effective anti-migraine drugs.

5-Hydroxytryptophan↗

[Importance of humoral mediators for the pathogenesis and treatment of migraine (author's transl)].

The vascular mechanism of migraine attacks -- intracranial vasoconstriction during the prodromal stage and passive vasodilatation of extracranial arteries during the painful phase -- has been confirmed by modern methods. In addition, number of humoral factors -- plasmakinin, serotonin, histamine -- intervene in the chain of events that culminates in migraine headache. In addition to these three humoral mediators, the part played by tyramine in migraine of alimentary origin, the precipitating effect of oestrogen decrease in menstrual migraine and the hypothetical role of prostaglandins and prolactin are discussed. The multifactorial mechanism of migraine accounts for the very variable profiles of effective anti-migraine drugs.

Acetates↗