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Biomedical subjects

B Bingham

Publications and source records attributed to B Bingham.

31 records · Page 2Linked to original sources
PubMed1991

The safety and efficacy of Emla cream topical anesthesia for myringotomy and ventilation tube insertion.

Emla cream is a eutectic mixture of lignocaine and prilocaine which can be used to anesthetize the tympanic membrane for myringotomy and ventilation tube insertion. This paper describes the anesthetic method and considers the safety and efficacy of this technique in 37 tympanic membranes from 29 adult patients. All of the patients easily tolerated the procedure. Patients with experience of previous tympanic membrane anesthetic techniques stated a preference for the Emla cream technique. No patient complained postoperatively of vertigo or tinnitus. Pure tone audiometry was performed on all 29 patients in whom a ventilation tube was inserted, both before tube insertion and at review consultation (between one month and 12 months after tube insertion. There was no audiometric evidence of ototoxicity.

Administration, Topical↗
PubMed1991

The organic composition of earwax.

Earwax is a mixture of desquamated keratinocytes and hair combined with the secretions of both the ceruminous and the sebaceous glands of the external ear canal. This study analyzed earwax using the combination analytical technique of gas chromatography and mass spectrometry. The major organic components of earwax identified were long chain fatty acids, both saturated and unsaturated, alcohols, squalene and cholesterol. This study demonstrated that it is not currently possible to quantify statistically the substances which constitute earwax with accuracy. The presence of foreign substances within earwax was identified as a complicating factor in the analysis of earwax.

Cerumen↗
PubMed1991

Persistence of the foramen of Huschke in the adult: an osteological study.

The foramen of Huschke, which appears during the embryological development of the tympanic bone, usually closes by the age of five years. A review of 377 dried skulls revealed that the foramen of Huschke was present in adult life in 7% of the skulls examined. A patent foramen of Huschke in the adult may, in rare cases, be the cause of temporomandibular joint herniation or fistulization through the anterior wall of the bony external canal.

Adult↗
PubMed1990

Quelprud's nodule: a post-auricular cartilaginous nodule.

A number of minor variations to the configuration of the external ear are well recognized. This paper brings attention to one entity which is characterized by a small cartilaginous nodule or prominence arising from the posterior surface of the pinna and which we have named Quelprud's nodule. A prospective clinical survey of 208 patients attending an ENT clinic revealed that nearly one-third of the population studied possess this nodule. There was an equal sex incidence. The Quelprud's nodule was identified within families in a distribution which suggests an autosomal dominant inheritance with variable expressivity.

Adolescent↗
PubMed1990

The organization and expression of the light gene, a heterochromatic gene of Drosophila melanogaster.

The light (lt) gene is located in the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster. This gene is necessary for normal levels of pigmentation in a number of adult and larval tissues and is required for viability. Hybrid dysgenic and X-ray induced mutations have been used to identify the gene and compare its organization to that of euchromatic genes. Molecular mapping of lt mutations and its major transcripts has shown that the lt gene is at least 17 kb. By injecting cosmid clones that include this region into lt mutant embryos, we have defined a 30-kb region that can transiently rescue the pigmentation defect in the Malpighian tubules. The major transcription unit of this gene is comprised of exons that are single copy. It is unusual in its organization in having a heterogeneous array of middle repetitive DNA sequences within its intronic and flanking regions.

Animals↗
PubMed1985

Targeted selection experiments and enzyme polymorphism: negative evidence for octanoate selection at the G6PD locus in Drosophila melanogaster.

Published studies have reported significant selection with respect to the G6pd locus for Drosophila melanogaster reared on Na-octanoate food. We have reexamined the selective effects of Na-octanoate on egg to adult viability with respect to the G6pd polymorphism using specially constructed X chromosomes. Four experiments were carried out using different 6Pgd backgrounds in two recombinant sets of chromosomes segregating for the G6pd locus but constructed so as to minimize variation over most of the X chromosome. In addition, two measures of viability were used, and the size of the experiments and their associated degrees of freedom are approximately double those reported in the former studies. Our results find no evidence for differential selection on G6pd genotypes (males and females) by Na-octanoate and, therefore, do not corroborate the positive results of selection reported by other investigators. The reasons for our different results are discussed.

Animals↗