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Biomedical subjects

B Bjerre

Publications and source records attributed to B Bjerre.

At least 37 records · Page 2Linked to original sources
PubMed1979

Prevalence of nine different micro-organisms in the female genital tract. A comparison between women from a venereal disease clinic and from a health control department.

In a study of the prevalence of nine different micro-organisms in the female genital tract in a Swedish population, significantly higher isolation rates occurred among women attending a venereal disease clinic than among those attending a gynaecological health control department. The prevalence of Candida albicans, however, was similar in different groups, individual susceptibility being the most important factor. Chlamydia trachomatis, Trichomonas vaginalis, and Mycoplasma hominis occurred concomitantly with Neisseria gonorrhoeae, indicating a similar epidemiology for all these agents. Younger patients seemed to have an increased susceptibility to C. trachomatis whereas older patients had an increased susceptibility to T. vaginalis.

Adolescent↗
PubMed1978

Further treatment after conization.

Conization was performed on 1,500 patients with carcinoma in situ of the uterine cervix. One hundred and seventy-five needed further treatment, 165 because of residual disease and 10 because of a recurrence. This finding indicates a recurrence frequency similar to the incidence of carcinoma in situ in a normal population.

Cervix Uteri↗
PubMed1976

Conization as only treatment of carcinoma in situ of the uterine cervix.

Knife conization was performed in 2,099 cases with abnormal vaginal smears. The frequency of complications was low. Carcinoma in situ was diagnosed in 1,500 cases and follow-up showed that conization was curative in 87%. The curative rate was depending on whether the resection margins were free of pathologic epithelium or not. If smears were repeatedly negative the first year after conization a new diagnosis of cancer was made in 0.4%. It was not possible to decide whether these lesions were residual changes or true recurrences. Treatment of carcinoma in situ by conization has so far reduced the frequency of invasive cervical cancer by 60%.

Adolescent↗
PubMed1976

Significance of obstetric factors in prognosis of low birthweight children.

Obstetric factors were studied in an unselected series of mothers of LBW-children and compared with those in a corresponding control series. Both groups consisted of 161 women with single pregnancies and 16 with twin pregnancies. Of the 188 LBW-children, 14% were twins. Of the single infants, 42% were appropriate for gestational age (AGA), i.e. within the 10th to 90th percentile according to Swedish curves for intrauterine growth, and 58% small for gestational age (SGA). The commonest causes of low birthweight (LBW) in the AGA-group were bleeding (34%) and premature rupture of the membranes (28%). In the SGA-group toxaemia was found in 15%, but in 50% of the SGA-group no cause of LBW was demonstrable. In this latter group the average placental weight was low. The mortality was noted and 89% of the living children were examined neurologically at 5 years of age. The prognosis of the child depended on the duration of pregnancy. Bleeding during pregnancy was a prognostically unfavourable sign, but even serious bleeding complications did not exclude a normal development of the child. The prognosis was best for those infants in whom no cause of LBW was demonstrable.

Birth Weight↗
PubMed1975

Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse.

Nerve growth factor (NGF) induced a marked increase in the adrenergic nerve terminal networks of several peripheral organs in intact adult and young adult mice. The animals were investigated at 3 days and at 2 months after 6 daily subcutaneous injections of the 7S species of NGF (1 mug/g body weight each dose). At 3 days after the end of the treatment an increased fluorescence intensity, as well as an increased density of the adrenergic terminal plexuses was observed by fluorescence histochemical techniques in iris, salivary glands, heart, intestine, spleen and pancreas. These changes were paralleled by significant increases (up to 55%) in the endogenous NA levels. Increased NA levels were also detected in the brain of the NGF-treated animals. At 2 months after treatment the effects had almost totally disappeared, demonstrating that the NGF-induced overgrowth of the sympathetic axons was only temporary. The increased adrenergic innervation probably resulted from a stimulatory effect of NGF on collateral sprouting from the intact adrenergic axons. In line with the idea that the terminals of peripheral axons are continuously renewed, it is suggested that endogenous NGF could play a regulatory role in such a continuous growth process of the fully developed, adult sympathetic nervous system, directed at the maintenance of an adequate adrenergic terminal network.

Age Factors↗
PubMed1975

A study of the de- and regenerative changes in the sympathetic nervous system of the adult mouse after treatment with the antiserum to nerve growth factor.

In the adult mouse, the antiserum to nerve growth factor (NGF) induced marked atrophic changes of the ganglionic cell bodies in the superior cervical ganglion (SCG) and a disappearance of adrenergic nerve terminals in several peripheral tissues. By fluorescence histochemistry a lower-than-normal content of the noradrenaline (NA) transmitter was observed within the entire adrenergic neurone only 1 day after a single injection of NGF-antiserum (0.1 ml/g body weight). An atrophy of adrenergic nerve cell bodies and a disappearance of adrenergic nerve terminals were observed after 3 days, but the antiserum-induced effects did not appear maximally developed until 7 days after treatment. These fluorescence histochemical findings were paralleled by a gradual decrease of the endogenous NA levels in peripheral tissues and also of the weight of the SCG. A gradually proceeding restoration towards normal of the adrenergic innervation apparatus was observed fluorescence histochemically following a 5-day treatment with NGF-antiserum (0.1 ml/g body weight each dose), and after 6 weeks to 3 months a normal or close to normal fluorescence microscopical appearance was regained in the peripheral tissues and also in the SCG. These findings were parelleled by the results of the determinations of endogenous NA in peripheral tissues and by the results of weighing the SCG. We discuss some important differences between NGF-antiserum and 6-hydroxydopamine with respect to their mode of action on the mature sympathetic nervous system. Finally, we suggest that a decreased availability of NGF in a terminal area, due to an interference with endogenous NGF by NGF-antibodies, may temporarily result in an impaired function of the supplying adrenergic neurone, including a degeneration of nerve terminals.

Animals↗