Biomedical subjects
Publications and source records attributed to B Bobrański.
Sixteen N-substituted urethanes were investigated as potential antiinflammatory agents. Most of them showed no stronger activity than phenylbutazone. The most active in the xylene hyperemia test were N,N'-dicarbethoxy-N,N'-dicyclohexyl-1,3-diaminopropane (XVI) and cyclohexyl piperidine-1-carboxylate (XIII). None of the studied compounds showed analgesic activity.
Fourteen new derivatives of hexahydro[1,4]diazepine-7H-5,7-dione were synthesized and tested for neurotropic activity. Some of them showed strong analgesic activity in the hot plate test.
Some new compounds containing cyclohexyl substituents, with a structure similar or analogous to that of traditional antiinflammatory drugs, were synthesized and their antiinflammatory activity was investigated. The strongest activity was shown by alpha-(p-cyclohexylphenyl)-gamma-valerolactone W 8.
A series of p-(N-barbituryl)phenyl- and cyclohexylalkanoic acids and their esters were synthesized. The preliminary pharmacological screening using the carrageenin, xylene and cotton tests revealed strong anti-inflammatory activity of several compounds in some of the tests performed, compound (Ij) being active in all the tests.
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Starting from 3,3'-spirobi-5-bromomethyltetrahydrofuranone-2 (2) the amino derivatives 3a--g were obtained. The pharmacological examination showed that the new compounds are deprived of the hypnotic activity characteristic for 3,3'-spirobi-5-methyltetrahydrofuranone-2 (2) and behaved in most tests as tranquillizers.
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