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B Bondy

Publications and source records attributed to B Bondy.

14 recordsLinked to original sources
PubMed1990

Methodology of 3H-spiperone binding to lymphocytes.

Alterations in lymphocyte binding capacity for the dopamine antagonist 3H-spiperone may be of great interest in psychiatric and neurological disorders: an increase in capacity noted in lymphocytes of schizophrenic patients and their families may well turn out to be a phenotypic vulnerability marker. Since the 3H-spiperone binding assay with lymphocytes does not fulfill common receptor-binding assay criteria and depends more on crucial analytical conditions, shortcomings in binding assay might possibly lead to irreproducible results. A detailed methodological description of the binding assay and subsequent calculations has therefore been given in this paper.

Binding, Competitive↗
PubMed1990

Mesenteric ischemia.

In all forms of mesenteric ischemia, early diagnosis and treatment is imperative. As this disease entity can be evident as a sole clinical event or a secondary event, close observation and suspicion of the diagnosis is advised in those who are at high risk. As the nurse caring for these patients, careful monitoring of the patient's fluid and electrolyte status, nutritional and gastrointestinal status is essential. This, along with assessing for complications and recurrence of ischemia, are the sine qua non of treatment for mesenteric ischemia.

Humans↗
PubMed1989

Influence of CGP 361A, propranolol and diazepam on autonomous reactions to different stressors.

1. To evaluate the influence of beta-blockers and minor tranquilizers on autonomous stress response, 40 healthy subjects selected with regard to personality traits were randomly assigned to 5 groups. 2. Mental arithmetic induced the most pronounced increase in heart rate (HR), blood pressure and epinephrine secretion. 3. Beta-blockers reduced HR increases due to mental stress, whereas the minor tranquilizer reduced skin conductance level throughout the whole trial. 4. Our data provide evidence that different structured situations induce specific response patterns that are differentially modified by beta-blockers and minor tranquilizer.

Adrenergic beta-Antagonists↗
PubMed1987

3H-spiperone binding sites in lymphocytes as possible vulnerability marker in schizophrenia.

The binding parameters for the dopamine antagonist 3H-spiperone to lymphocytes were investigated in nonmedicated schizophrenics (N = 43), in medicated schizophrenics (N = 25), as well as in 38 first- and second-degree relatives of schizophrenics, in a psychiatric control group (N = 27) and in normal, healthy controls (N = 40). The density of lymphocyte 3H-spiperone binding sites (Bmax) was significantly increased in all acute and chronic schizophrenic patients and in patients undergoing neuroleptic treatment for 2 weeks to several months and remained on a constant level during a drug-free remission period, suggesting that Bmax is a state independent variable. Elevated binding seems to be associated with schizophrenia; it could not be found in other psychiatric patients. In pedigree and family studies it became obvious that all relatives with one or more previous episodes of schizophrenia had similar increased binding capacity. But even in some well-state relatives elevated spiperone binding could be found, although they never had symptoms of the disease. Among these relatives of schizophrenics, there was an association between increased spiperone binding and the transmission of the disease. Although conclusive data about the precise genetic control obtainable in twin studies are still missing, we would suggest that elevated lymphocyte spiperone binding may be a marker of susceptibility to schizophrenia.

Adolescent↗
PubMed1985

Binding of 3H-spiperone to human lymphocytes: a biological marker in schizophrenia?

The specific binding of the dopamine antagonist 3H-spiperone to lymphocytes from a healthy control group (n = 40), a group of acute, unmedicated schizophrenic patients (n = 27), and a psychiatric control group (n = 16) was investigated. There were no differences in binding parameters between the healthy controls (Bmax 2.6 +/- 0.7 fmoles/10(6) cells; Kd 0.17 +/- 0.07 nM) and the psychiatric control group. Binding capacity of 3H-spiperone was significantly increased in lymphocytes from the schizophrenic patients (Bmax 14.4 +/- 9.3 fmoles/10(6) cells). Moreover, a slight decrease in affinity was observed (Kd 0.44 +/- 0.21 nM). Because the increase in binding appeared only in schizophrenic patients, this peripheral model could prove valuable as a diagnostic criterion.

Acute Disease↗
PubMed1976

Significance of daily rhythm for the interpretation of functional diagnostic procedures.

For the first time, the reaction of the cardiovascular system during day and night in young people was examined. We were mostly interested in the influence of the nervous system and any autonomic mechanism. We examined 20 subjects at 4-hour intervals on the ergometer (active exercise) and on the tilt-table (passive exercise) to find out the rhythm in the circulatory regulation. The test person was kept in vertical position on the tilt-table for 10 minutes. On the ergometer he had to perform a work-load of 100 Watt for 10 minutes. We measured pulse rate and blood pressure; we introduced new terms for the evaluation. "Orthostatic Index" and "Performance Index" will be further explained. The results were: A minimum in the orthostatic stability around 1 p.m. and 1--5 am, and a performance maximum at 1 p.m. and 5 p.m. Further details will be reported.

Blood Pressure↗
PubMed1976

Methods of measuring physical fitness.

Clinical pharmacology is in need of standarized test-methods for guaranteeing objective controls of therapeutic efficacy. In the field of cardiology, test methods had been created for electrocardiographic and special cardiologic examinations by Kaltenbach, Korkmann et al. For objectivating the therapeutic success in hypertension and orthostatic tolerancy, some regimens had been made and published in their journal, according to the test methods of Kirchhoff. This report is to discuss the criteria which show an assessment for the range and the limit of efficacy of functional circles and circular systems determining the efficiency.

Blood Pressure↗
PubMedDate not supplied

[Catecholaminergic receptors of the blood cells of schizophrenics].

The simultaneous determination of serum CA and their receptors in blood cells offers a possibility to evaluate disturbances of the DA and NA neuronal systems in man. High affinity binding sites for 3H-yohimbine in platelets, 3H-DHA on granulocytes and 3H-spiperone in lymphocytes from healthy control persons, unmedicated (n = 28), and medicated (n = 8) schizophrenics as well as from an unmedicated psychiatric control (n = 14) were investigated. Furthermore, the actual concentration of the circulating CA was determined with HPLC-ECD. In unmedicated schizophrenics as compared to controls, specific binding of 3H-spiperone to lymphocytes was markedly elevated in capacity and less in affinity as compared to controls. For beta2-receptors a significant decrease was found in capacity with no change in affinity. The changes in alpha2-receptors with a slight decrease in capacity were less distinct. The concentrations of circulating CA ranged from normal values up to a more than 3 fold increase in NA and DA, whereas A concentrations were practically unchanged. No overall change in these data was found in the medicated schizophrenic patients. 3H-spiperone binding was characteristically increased only in schizophrenics, but did not elevate above control data in the non-schizophrenic psychiatric control group. Preliminary experiments of family studies suggest that this model could be valuable as a vulnerability marker.

Adult↗