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Biomedical subjects

B Bouillon

Publications and source records attributed to B Bouillon.

9 recordsLinked to original sources
PubMed1992

[Multiple trauma: preclinical needs, transportation, time sequences].

Compared to the magnitude of the trauma problem few precise data exist on prehospital care of trauma patients. The aim of the study was the collection and careful evaluation of prehospital data on trauma patients concerning time sequences, patients' status and prehospital interventions. From 1. 1. 1987 to 31. 12. 1990 all 49,045 prehospital emergencies in Cologne were prospectively registered. 8792 trauma patients were treated by an emergency physician in the field. 9.5% were severely injured, defined by a trauma score less than or equal to 12. 9.9% of the trauma patients were intubated, 54.9% received an i.v. line, and 20.6% were triaged to a trauma center. Our data form a valid base for analysis of the effectiveness of prehospital trauma care.

Adult↗
PubMed1992

Pharmacotherapy in shock syndromes: the neglected field of pharmacokinetics and pharmacodynamics.

Promising effects of adjuvant drugs in experimental shock models often are not confirmed in subsequent clinical trials, e.g., steroids, fibronectin, naloxone, immunotherapeutics. A key difficulty in establishing a therapeutic benefit in clinical studies, apart from study design shortcomings, is the lack of knowledge and application of principles of clinical pharmacokinetics and -dynamics. In shock states the relationship between an administered fixed dose regimen and the drug effect is strongly influenced by dynamic changes in absorption, distribution, metabolism, and elimination of the drug, all of which vary between individual patients. This article describes several neglected aspects of clinical pharmacology relevant to shock research under clinical conditions and discusses the indications, prerequisites, and limitations of "applied pharmacokinetics." The inclusion of therapeutic drug monitoring in clinical shock studies should be applied more frequently to establish experimental results in the "real world" of ICU settings.

Animals↗
PubMed1991

[Glucocorticoids in multiple trauma and infection--still a topic for discussion?].

The clinical use of glucocorticoids in trauma and sepsis has not yet been approved on the basis of clinical trials. Current knowledge in the area of pathogenesis is reviewed, and against this background the mechanisms of steroid action will be discussed, the current status of clinical testing in both trauma and sepsis will be evaluated, and ways of testing the effectiveness will be proposed. Although most trials up to now have shown a positive overall effect in trauma patients, a further prospective randomized controlled study with a more homogeneous study population and including trauma scores is necessary before trauma can be reliably accepted as a firm indication for glucocorticoid treatment. In the discussion on sepsis syndrome a variety of reasons are suggested for the failure of earlier studies to show beneficial effects. Besides methodological aspects, one of the main reasons is the neglected field of pharmacologic-pharmacokinetic principles. A new study should be performed under therapeutic drug-monitoring (TDM) conditions once more is known about the target concentration range.

Animals↗
PubMed1989

[Quality of life--criterion in the treatment strategy of severely injured patients].

A cohort study of 202 patients showed that all different aspects of quality of life--physical function, psychological function, social function and symptoms--were altered after multiple injury. Sixty-three percent of the patients rated their quality of life after trauma as average or bad. Since the quality of life is a relevant problem after trauma, it is necessary to use it as an important endpoint to judge results after multiple injury. Findings from such studies must be integrated into existing diagnostic and therapeutic concepts.

Activities of Daily Living↗
PubMed1989

[Score systems, their importance for the intensive care patient].

Scoring systems are a technique for defining patients for scientific and management purposes. A hypothetical, severely ill patient with cirrhosis, peritonitis, renal insufficiency and coagulation problems can be precisely classified: Child C, Mannheim-Peritonitis-Index 34 and APACHE II score 27 which results in a mortality of at least 70% of patients. At our own hospital, the continuous APACHE score (CAPS) has been developed and tested. The CAPS performed better than daily APACHE scores and provided useful trend information for the individual patient.

Critical Care↗
PubMed1989

[Biocompatibility and mechanical strength of various dura mater preparations after intraperitoneal implantation in rats].

Biocompatibility and mechanical strength of 3 different dura mater preparations were studied during 1, 2 and 4 weeks in a rat model. Two preparations produced by conventional methods did not markedly differ, whereas the third one, which had been freeze-dried after addition of glycerol, exhibited some special properties, showing higher mechanical strength throughout the whole period of implantation, and lower tendency to form adhesions, and inducing weaker leucocytic reaction. For certain surgical problems this soft, strong and compatible dura preparation could be an appropriate alternative.

Animals↗
PubMed1987

Quality of life: an important endpoint both in surgical practice and research.

Surgery asks patients to trade present discomfort and risk for future gains. Although research reports on the effectiveness of surgery have largely focused on mortality, length of hospital stay, major complications, and laboratory analyses, the principal criteria guiding surgeons' clinical decisions and patients' acceptance of treatment are most often the patients' subjective feelings and capabilities, the quality of their lives. This is true for both major and minor surgical procedures. We discuss the role of information on functional capacity, overall well-being, and quality of life in the assessment of surgical outcomes. Broadening the choice of endpoints beyond traditional, so-called "hard" variables in surgical studies has advantages for both surgeons and patients.

Clinical Trials as Topic↗
PubMed1985

[Gastric outlet stenosis (benign): definition, incidence, therapy?].

According to a strict definition of a benign gastric outlet obstruction i.e. delayed vomiting, changing of symptoms, weight loss and intraoperative test by Hegardilators (less than 14), 2.2% real stenoses among 619 operative treated duodenal ulcer patients were found. All patients were treated by SPV and digital dilatation of the stenosis through a gastrotomy. During up to a 10 year follow-up no reoperation was necessary. All patients showed Visick-classification of I and II. In conclusion SPV with digital dilatation showed good clinical results for patients with benign gastric outlet obstruction in long-term follow up.

Adult↗