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Biomedical subjects

B Bower

Publications and source records attributed to B Bower.

27 records · Page 2Linked to original sources
PubMed1982

In vitro lymphocyte blastogenic responses and titers of humoral antibodies from periodontitis patients to oral spirochete isolates.

Humoral antibodies and in vitro blastogenic responses of patients with moderate to advanced periodontitis and of orally healthy (control) individuals to 11 spirochetes were assayed. Eight isolates of Treponema denticola, two isolates of T. vincentii, and one isolate of T. phagedenis were grown anaerobically, sonicated, and centrifuged to remove cellular debris. The blastogenic responses of peripheral blood lymphocytes were measured by [3H]-thymidine uptake. Antibody titers (immunoglobulins A, G, and M) to the spirochetes were measured with the micro-enzyme-linked immunosorbent assay. Dark-field microscopic enumeration of spirochetes was made from subgingival plaque. Spirochetes comprised 20% of the total number of microorganisms seen in plaque from the patients, whereas no spirochetes were seen in plaque from the controls. The blastogenic responses to the spirochetes were not statistically different (P greater than 0.05) between patients and controls. The immunoglobulin G and M antibody titers of the patients were generally lower than the titers of the controls, but the differences were rarely statistically significant. In contrast, the patients possessed significantly higher immunoglobulin A titers to seven spirochetes (T. denticola). No correlation was found between the percentage of spirochetes in the plaque sample and the blastogenic responses or titers of antibodies from an individual to the 11 spirochetes.

Adult↗
PubMed1980

Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.

Of the 265 children aged between 6 and 18 months admitted to hospital in a 26-month period each with his first febrile convulsion, there were 64 who satisfied our criteria for a simple febrile convulsion. Of these, 43 (random) were entered into a double-blind trial of continuous sodium valproate versus phenobarbitone, and 21 were untreated. The dosage was phenobarbitone 3-6 mg/kg per day; sodium valproate 30-60 mg/kg per day. 39 completed treatment (21 phenobarbitone, 18 sodium valproate), 2 in each group being withdrawn because of unacceptable side effects. Close supervision and random serum drug estimations showed compliance to be good. After a mean treatment period of 12 months (mean age 25 months) there had been one recurrence in the sodium valproate group compared with 7 in the untreated group (P less than 0.05), and 4 recurrences in the phenobarbitone group. The difference between treatment and no treatment was significant (P less than 0.05). These results suggest that in simple febrile convulsions occurring between 6 and 18 months of age sodium valproate is as effective as phenobarbitone in preventing recurrence and that either treatment is better than none.

Clinical Trials as Topic↗
PubMed1978

Neurogenic galactorrhea-amenorrhea.

Neuroendocrine function in two women with galactorrhea-amenorrhea arising from abnormalities in the PRL reflex arc was compared to that of normal women. Basal gonadotropins were lower than normal, and one patient lacked episodic secretion of LH; however, the serum gonadotropin rise after iv LRH was in the normal range in both patients. Mean basal PRL levels were slightly elevated in one patient and were normal in the other, and the PRL levels after TRH, chlorpromazine, and levodopa testing were similar to those seen in normal women. Breast stimulation did not increase PRL levels in either patient. PRL levels fell with bromergocryptine therapy, galactorrhea ceased, and normal menses resumed. These studies indicate that chronic afferent impulses originating in the PRL reflex arc can result in galactorrhea and amenorrhea and that bromergocryptine therapy in such patients can restore normal menses.

Adult↗