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Biomedical subjects

B Braffman

Publications and source records attributed to B Braffman.

22 records · Page 2Linked to original sources

The phakomatoses: Part II. von Hippel-Lindau disease, Sturge-Weber syndrome, and less common conditions.

The phakomatoses appear to represent a group of disorders characterized, in part, by the common features of neuroectodermal mal-development, undecided differentiation of cells, and disturbed patterns of cell migration. With progress in genetics and cell biology, the precise deficits in the genome and the specific biochemical abnormalities associated with these defects will be elucidated. It is expected that the apparent diversity of these lesions will then be understood as a coherent series of missteps along the common pathway of normal growth and development.

Adult↗

Diagnosis and imaging of gastrointestinal tract cancers.

Recent trends in the diagnosis and imaging of cancers of the gastrointestinal tract include developments in screening for colorectal cancer and innovations in ultrasonography and magnetic resonance imaging of primary and metastatic hepatic tumors. Mathematical models suggest that screening for colorectal cancer will be as cost-effective as several other widely accepted screening programs, including the Papanicolaou smear for cervical cancer and screening mammography. There is considerable discussion regarding the relative roles of procedures such as fecal occult blood testing, sigmoidoscopy, colonoscopy, and radiology in screening strategies. The issue remains unsettled. In ultrasonography, the use of intraoperative ultrasound allows for the detection of more metastatic lesions in the liver than do preoperative computed tomography and ultrasound. Esophageal endoscopic ultrasonography has been used for the preoperative assessment of depth of invasion by esophageal cancer. The technique is limited in cases of stenotic cancer in which the endoscope cannot be passed through the lesion. Similarly, endorectal ultrasound can be used for staging of rectal cancer. Color Doppler ultrasound has been used for the evaluation of blood flow in relationship to hepatic neoplasms. Magnetic resonance imaging has been used not only for detecting liver tumors but also for differentiating between neoplasm and hemangioma.

Diagnostic Imaging↗

Subdiaphragmatic bronchogenic cyst with gastric communication.

Upper gastrointestinal series and computed tomography of the abdomen in an elderly women demonstrated a large multiloculated mass in the left subphrenic space that communicated with the fundus. The resected specimen showed histopathological features of bronchopulmonary foregut malformation.

Bronchogenic Cyst↗