Biomedical subjects

B Browne

Publications and source records attributed to B Browne.

26 records · Page 2Linked to original sources

PubMed1987

Lithium intoxication: manifestations and management.

The clinical diagnosis of lithium intoxication can be elusive because of the slow onset and diversity of toxic manifestations. Mental status and neurologic symptoms often predominate. After the diagnosis is made, management depends on the clinical presentation and serum lithium level. Hemodialysis is the treatment of choice for severe lithium intoxication. Two cases of lithium intoxication are presented that demonstrate that predisposing factors and drug interactions play major roles. A review is given of the pathophysiology, presenting signs, symptoms, and approaches to treatment of lithium intoxication.

Adult↗

PubMed1987

Monoamine oxidase inhibitors and narcotic analgesics. A critical review of the implications for treatment.

There has been a recent renewal of interest in the use of monoamine oxidase inhibitors, but the concurrent administration of narcotic analgesics is often a cause for concern. This review clarifies the different types of MAOI/narcotic interactions and offers guidelines for the use of narcotic analgesics in the presence of MAOIs. The MAOI/pethidine interaction has two distinct forms: an excitatory and a depressive form. Pethidine must never be used in the presence of MAOIs because of the risk of a fatal excitatory interaction. Morphine does not cause this excitatory interaction, and is the drug of choice provided an allowance is made for possible potentiation of the depressive narcotic effect. It is inevitable that strong analgesia will occasionally be required as an emergency measure in patients on MAOIs, and insufficient attention is paid in psychiatric textbooks to the two different types of interactions and their therapeutic implications.

Adult↗

PubMed1986

Structure-activity relationships of enkephalins containing serially replaced thiomethylene amide bond surrogates.

An isomeric series of four leucine-enkephalin analogs containing the thiomethylene ether unit as an amide bond replacement in all positions have been prepared by solid phase methods. The resulting pseudopeptides divulged widely differing retentive behaviors on reversed phase high performance liquid chromatography (HPLC). An analog containing the Phe psi[CH2S]Leu dipeptide replacement at the 4-5 position exhibited binding close to the parent, leucine enkephalin; its guinea pig ileum (GPI) activity was the highest of the analogs tested. Another compound, Tyr psi[CH2S]Gly1-2]-Leu-enkephalin, also displaced 3H-etorphine well in the binding assay, but caused increased contractions in the GPI assay at low concentrations. The Phe psi[CH2S]Leu results are not compatible with the necessity of a beta-turn structure for agonist activity in the GPI assay.

Amides↗

PubMed1986

Planned role change: avoiding political pitfalls.

Modern health care has placed increasing demands on health professionals to expand their roles or to create new roles in order to provide comprehensive service to clients. An understanding of various social theories is an essential background when planning and undergoing a process of transition from one role to another. The authors have applied principles from these theories to the process of role change or innovation in organizations. A problem-solving format is used to outline the process of entry to a clinical system and planning a role change. This practical guide formulates the questions to be addressed during the process and can be used by practitioners or by educators of any professional discipline.

Health Workforce↗

PubMed1984

Quantitative studies of the evolution of the thalamus in primates.

A quantitative study of the thalamus and metathalamus has been carried out on brains of six different primate species. The allometric formula devised by Stephan, Bauchot and Andy (1970) has been slightly modified as two steps have been utilized in order to attain the required magnification of the final photomicrograph (a positive print, as opposed to Stephan et al's negative print). The thalamic and metathalamic structures are divided on the basis of their developmental stages into two groups--paleothalamus and neothalamus, so that their proportions to each other in primate phylogeny can be estimated. The results show that the neothalamus extends the paleothalamus by two-thirds (2/3rds) in Tupaia and by more than three-quarters (3/4ths) in Cercopithecus. Of all the thalamic groups, the dorsolateral thalamic nuclear group is most dominant in all primate species, except Tupaia, where the ventrolateral thalamic nuclei are larger than all other nuclei. The pulvinar is the most dominant nucleus in all species except Tupaia. These quantitative results conform, in most places, with the observations of other researchers, while they do not agree much with the qualitative observations of the thalamus in the same species (Simmons 1974). How this study has a bearing on the phylogenetic positions of the Tupaioidea and the Tarsioidea in the Primate Order, is briefly discussed.

Animals↗

PubMedDate not supplied

The electrocardiographic features of hypothermia.

Hypothermia results in the development of several characteristic electrocardiographic changes. As the core body temperature decreases, several changes in cardiac rhythm occur. Prolongation of the PR, QRS, and QT intervals are also seen. Muscle tremor artifact may be present, even in the absence of clinical shivering. A characteristic secondary deflection on the terminal portion of the QRS complex (Osborn wave) is usually found. All of these features are reversible with rewarming.

Arrhythmias, Cardiac↗

PubMedDate not supplied

Interpretation and clinical significance of the QRS axis of the electrocardiogram.

The frontal plane QRS axis of the standard 12-lead electrocardiogram (ECG) is easily and accurately measured by the clinician. A simple method of estimating this axis is discussed. This axis is age-dependent. We reviewed the literature to determine if evidence exists of an association between an "abnormal" QRS axis and clinically significant myocardial disease. We also examined the literature for clinical correlation of a "normal" QRS axis with the absence of myocardial pathology. We found that although an abnormal QRS axis (falling outside the limits of +30 degrees and +90 degrees) occurs in a small number of normal individuals, its presence should prompt a thorough evaluation of all the parameters of the ECG to look for myocardial disease.

Cardiomyopathies↗

PubMedDate not supplied

The importance of an annual report.

An annual report, by summarizing the emergency department's accomplishments, is an effective means of highlighting the vital role of the emergency department within the hospital system and the community. The report should begin with an Executive Summary and proceed to detail the clinical, educational, research, administrative, financial, and other essential aspects of the status and development of the department.

Annual Reports as Topic↗