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Biomedical subjects

B Bussel

Publications and source records attributed to B Bussel.

90 records · Page 5Linked to original sources
PubMed1976

Human sleep and 5-HTP. Effects of repeated high doses and of association with benserazide (RO.04.4602).

On account of the conflicting data concerning the action of 5-HTP on human sleep, repeated high doses were administered to three healthy subjects. The paradoxical sleep time and percentage tend to show a decrease during the 2nd week of treatment, followed by a rebound effect after the end of the treatment. In two subjects who initially had a small amount of slow wave sleep (SWS), the treatment induced an increase in SWS that persisted after the end of the treatment. Similar results were obtained after administration of 5-HTP together with RO.04.4602.

5-Hydroxytryptophan↗
PubMed1976

Excitability of human motoneurones after discharge in a conditioning reflex.

A new method of exploring the H reflex excitability cycle is proposed which permits the exploration of motoneurones that discharged in response to the conditioning shock. This is made possible by using a test stimulus supramaximal for the alpha motor fibres of the nerve, which causes a collision in the alpha fibres between the orthodromic conditioning reflex volley and the antidromic motor volley. As a result of this collision, a test reflex contraction appears in the EMG, due to motoneurones that have already discharged in the conditioning response. This method permits studies in human subjects of the poststimulus refractory period of motoneurones as well as the early inhibitory phenomena related to the conditioning stimulus and response. It is shown that during the initial period of the classical H reflex excitability cycle, the test shock explores only alpha motoneurones corresponding to a fringe of cells subliminally excited by the conditioning stimulus. The difference between the populations of motoneurones tested by the two methods explains the differences between the features of the cycles obtained.

Evoked Potentials↗
PubMedDate not supplied

Post-traumatic haemorrhage in corpus callosum: a case study of disconnection syndrome.

This paper reports the case of a 16-year-old man who had sustained a traumatic head injury. Neuroradiological examinations showed haemorrhagic lesion in corpus callosum. The patient initially demonstrated several symptoms of disconnection syndrome; however, these clinical signs later resolved in subtle dysfunctions that could be evidenced only by statistical analyses of performances to specific tests. It is thus suggested that comparable cases may be undetected by standard examination procedures.

Adolescent↗
PubMedDate not supplied

[The role of vestibular and proprioceptive afferent pathways in the reaction to pushing (author's transl)].

The reaction to pushing was studied in 6 normal subjects and 3 patients with bilateral peripheral vestibular lesions. The reaction to pushing was tested on the anterior tibial and soleus, by modifying the proprioceptive afferent impulses. The respective parts of the vestibular, proprioceptive, visual components, and of a sudden, start are analyzed; the afferent impulses obtain information from the initial posture and modulate the relative importance of these different factors at a supra-segmentary level.

Afferent Pathways↗
PubMedDate not supplied

[Physiopathology of spasticity and flexion spasms].

Spasticity, flexion and extension spasms occur after lesions of motor descending pathways. Three different mechanisms can explain these disorders of tone: pure muscular alterations, segmental synaptic sprouting and liberation of spinal reflex activity. This last mechanism, which is also the most classically described has been studied long ago. Amongst all hypotheses which can explain spasticity (hyperexcitability of alpha motoneuron, gamma motoneuron, or reduction of presynaptic inhibition) reduction of presynaptic inhibition is the only one to have been clearly demonstrated. A new treatment is proposed: intrathecal Baclofen. It seems to act by reducing the excitability of alpha motoneuron.

Baclofen↗