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Biomedical subjects

B C Corya

Publications and source records attributed to B C Corya.

28 records · Page 2Linked to original sources

M-mode echocardiography in the evaluation of patients for aneurysmectomy.

In order to determine whether echocardiography could be useful in predicting surgical mortality of aneurysmectomy, preoperative condensed M-mode echocardiographic scans were taken from both mid (standard position) and low (nearer apex) intercostal spaces and/or from the subxiphoid area in eighteen patients who were sent to surgery for aneurysmectomy. Eleven of the eighteen patients survived aneurysmectomy. All eleven had mid left ventricular dimensions less than 3.3 cm/m2 and low dimensions of 3.8 cm/m2 or less. Of the seven patients who died, the mid and low left ventricular dimensions exceeded 3.3 cm/m2 and 3.8 cm/m2, respectively, with one exception. The combination of abnormal mitral valve closure, a dilated mid dimension and lack of normal motion in opposing wall segments was only seen in six nonsurvivors. Echocardiography can provide information concerning the state of the left ventricle in patients with ventricular aneurysms and these findings may be helpful in predicting surgical mortality for aneurysmectomy.

Adult↗

Serial echocardiographic abnormalities in nonbacterial thrombotic endocarditis of the mitral valve.

This report describes the clinical course and serial echocardiographic abnormalities in a patient with nonbacterial thrombotic endocarditis and repeated embolic episodes. Serial echocardiograms revealed a mass of abnormal echoes on the anterior mitral leaflet and progressive restriction of mitral valvular motion. Cineangiographic studies demonstrated a large filling defect in the area of the mitral valve. Surgical intervention confirmed the presence of a large vegetation on the mitral valve. The surgical specimen consisted of a sterile, partially organized fibrin thrombus. The echocardiographic abnormalities are described and discussed in relation to the clinical and pathologic findings.

Adult↗

Coronary angiographic, echocardiographic, and electrocardiographic studies on a patient with variant angina due to coronary artery spasm.

A 45-year-old Caucasian female patient with a clinical rehistory and ECG's conforming to the syndrome of variant angina as characterized by Prinzmetal is presented. ECG's recorded during spontaneous pain demonstrated ST-segment elevation and symmetrical peaking of the T-waves in the lateral precordial leads and short runs of ventricular tachycardia. Similar ECG changes were recorded during treadmill exercise- and hand-grip exercise-induced chest pain. An echocardiogram recorded during angina induced by hand-grip exercise demonstrated progressive flattening of septal motion. Multiple views of the coronary system by selective coronary cineangiography were normal with the patient at rest. Angina was then induced by hand-grip exercise and a repeat right anterior oblique view of the left coronary system revealed marked spasm of the left anterior descending artery proximal to the first septal perforator.

Angina Pectoris↗

Echocardiography in acute myocardial infarction.

Sixty-four patient with acute transmural myocardial infarction had daily echocardiograms while in the coronary care unit. Patients with previous infarction were excluded. The electrocardiographic site of infarction was anterior wall in 28, inferior wall in 33 and both anterior and inferior wall in 3 patients. Echocardiograms satisfactory for interpretation were obtained in 92 percent of cases. Abnormal left ventricular wall motion corresponding to the electrocardiographic site of infarction was seen in the echocardiogram in 84 percent of cases. Exaggerated normal motion in noninfarcted areas was seen in 30 percent. The left ventricular internal dimension correlated with clinical heart failure (P less than 0.005) and was increased in 50 percent. Abnormal mitral valve closure, which reflects increased left ventricular end-diastolic pressure, was present in 33 percent. This finding did not correlate significantly with clinical heart failure. By combining the measurements of left ventricular internal dimension and mitral valve closure, it was possible to predict hospital mortality from the echocardiograms. The results indicate that echocardiography is a useful technique in the study and management of patients with acute myocardial infarction.

Acute Disease↗

Myocardial blood flow response to isometric (handgrip) and treadmill exercise in coronary artery disease.

Thirty patients undergoing coronary cineangiography for diagnosis or evaluation of coronary artery disease had myocardial blood flow studies pre and post handgrip (isometric) exercise just prior to cineangiography. The handgrip was maintained at one-third maximum effort for three minutes. The patients also had treadmill exercise testing a day or two prior to the study. Treadmill testing was carried out until angina or positive ST-segment changes occurred or the patient attained 90% of predicted maximal heart rate. Of the 30 patients, seven had no coronary artery disease and 23 had significant disease, i.e., greater than 75% occlusion of at least one major coronary artery. Six of the 23 patients (26%) with disease had angina with handgrip and demonstrated a decreased myocardial blood flow, a significantly different response from the patients without agina (P less than 0.001). For the group without angina, the blood flow response was not significantly different from the normal group. Treadmill tests were positive in 19 of the 23 patients with coronary disease (83%). The arterial systolic and diastolic pressure rise was almost identical with the two stresses. The heart rate response, however, was significantly different (P less than 0.001), the rate increase being greater with treadmill exercise. The myocardial blood flow data demonstrate the relative insensitivity of handgrip exercise for the diagnosis of coronary artery disease. In terms of the supply demand ratio (diastolic pressure time/systolic pressure time) concept for subendocardial perfusion, it is possible that the difference between handgrip and treadmill stress may be due to the different heart rate response, more rapid heart rates having a relatively greater effect on diastolic than on systolic time indices, all other factors being equal.

Angina Pectoris↗

Applications of echocardiography in acute myocardial infarction.

Echocardiography has many attributes that are desirable for diagnostic and research studies in acute myocardial infarction patients. It does not alter the physiologic state being evaluated, is relatively inexpensive, and does not interfere with other hospital procedures. For these reasons, the test may be repeated frequently and used to monitor the changes after acute infarction. Useful information about left ventricular volume, diastolic pressure, and segmental wall motion may be obtained. Because echocarciographic estimates of stroke volume, ejection fraction, and velocity of circumferential fiber shortening are based on motion seen in only one "ice-pick" view of the heart, it is likely that they will be less reliable in patients with asynergy of contraction. Although a definite diagnosis of acute myocardial infarction cannot be made by echocardiography, abnormalities of wall motion may occur very early and support a clinical impression of infarction. An echocardiogram may also reveal changes suggesting ischemia or infarction (abnormal motion) in patients who have atypical chest pain and no other objective evidence of coronary artery disease.

Acute Disease↗

The diagnostic attributes of echocardiography in the patient with chest pain or pulmonary edema.

In the critically ill or clinically unstable patient, echocardiography is particularly useful in that it provides a safe, painless, and yet reliable bedside method for evaluating the anatomy and physiology of the heart. In addition to diagnostic information, serial echocardiograms may be obtained as often as clinically indicated to monitor and detect hemodynamic changes which may be of prognostic value to the clinician. The ultimate role of echocardiography in coronary artery disease is not yet known, and many of the observations and uses we have discussed are still being investigated and substantiated. For the individual patient with coronary artery disease, it is too early to know whether the information available from the echocardiogram will influence the course or outcome of the disease.

Aortic Dissection↗