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Biomedical subjects

B C Frichot

Publications and source records attributed to B C Frichot.

10 recordsLinked to original sources
PubMed1978

Familial atypical multiple mole-melanoma syndrome.

A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.

Adult↗
PubMed1978

Spontaneous regression of metastatic malignant melanoma in 2 sibs with xeroderma pigmentosum.

The clinical and pathology findings in 2 sibs with xeroderma pigmentosum (XDP), complicated by metastatic malignant melanoma which underwent spontaneous regression, are described. The pathology of one of these patients showed features of possible spontaneous regression, namely foamy histiocytes, capillary proliferation, and a chronic inflammatory infiltrate which was devoid of malignant cells, suggesting the possibility that an immunological mechanism was at work. It was of interest that a recent review of 27 cases of spontaneous regression of metastatic melanoma since 1900 contained a patient with XDP. Adding our 2 cases, at least 10% of the spontaneous regressions of metastatic melanoma occurred in patients with XDP. This unusual association raised the question that the genotype for XDP may possibly foster control of metastatic malignant melanoma in some as yet unknown way.

Adult↗
PubMed1977

Cancer control in xeroderma pigmentosum.

This study of identical twins affected with xeroderma pigmentosum, with follow-up and re-evaluation after a period of eight years, is unique in that it demonstrates clearly the value of cancer control methods, primarily the avoidance of solar radiation. The findings in the identical twins have been evaluated in context with their other affected siblings who also have shown a remarkable low rate of skin cancer upon initiation of cancer control (solar radiation avoidance).

4-Aminobenzoic Acid↗
PubMed1975

Family studies of malignant melanoma and associated cancer.

This study comprises five cancer prone families with one or more occurrences of melanoma in context with a variety of other histologic types of cancer, including an excess of multiple primary malignant tumors. The genetic mode of transmission of cancer in each family was consistent with a dominant factor which has seemingly predisposed these patients to a general cancer diatheses. The tumor spectrum included malignant melanoma and cancers of the breast, gastrointestinal tract, lung and lymphoproliferative system. Recently, S1 and S2 antigens were noted to occur with malignant melanoma and the same variety of tumors which have occured in these five families.

Adult↗