Biomedical subjects
Publications and source records attributed to B C Lamkin.
There are numerous cutaneous findings associated with liver diseases. Although most of these changes are nonspecific and therefore are of limited value in the actual diagnosis of hepatic disease, recognition of the association may be useful for diagnosis and for monitoring the patient's response to treatment.
A case of Staphylococcus aureus--induced bullous dermatosis limited to the sites of glucocorticosteroid-induced striae atrophicae is described. Skin with compromised mechanical integrity may be more susceptible to disruption by invasion of bacteria and/or by their exotoxin. The pathogenesis of striae atrophicae and the mechanism of blister formation by S. aureus are reviewed in an effort to relate these two phenomena.
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Juvenile dermatitis herpetiformis occurred in a 20-month-old girl. She had granular lgA, C3, and fibrin bound to the basement membrane zone of the skin by direct immunofluorescence and negative serum antibodies against the skin on indirect immunofluorescence. The HLA typing of peripheral lymphocytes was A1, Aw30, B8, Bw51 without clinical evidence of malabsorption syndrome. A rapid improvement was observed on dapsone therapy. These findings strongly suggest that juvenile dermatitis hepetiformis is a disease entity different from chronic bullous dermatosis of childhood.