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Biomedical subjects

B C Mehta

Publications and source records attributed to B C Mehta.

At least 55 records · Page 3Linked to original sources
PubMed1989

Effect of iron deficiency on renal function.

Renal function was assessed by determining three hour creatinine clearance (THCC) values in 20 patients (13 males, seven females; age 16-55 years) of nutritional iron deficiency anaemia. Mean transferrin saturation was 4.6% (SD 2.3). Haemoglobin and THCC were determined twice at the interval of three days before therapy. All patients received total dose iron-dextran intravenously. Three days after therapy, haemoglobin and THCC were determined again. Paired 't' test was used to determine the significance of the difference. There was no significant difference between the two pretherapy mean haemoglobin values (6.1 +/- 3.5 g/dl and 5.6 +/- 4.5 g/dl; p greater than 0.2), and the two pretherapy mean THCC values (67.2 +/- 36.9 ml/min and 70.3 +/- 22.8 ml/min; p greater than 0.5). There was no significant difference (p greater than 0.5) between pre-and post-therapy mean haemoglobin levels (6.6 +/- 2.2 g/dl). The difference between the pre-therapy and post-therapy THCC (95.3 +/- 34.0 ml/min) was statistically significant (p less than 0.01). It is concluded on the basis of these results that renal function as measured by THCC is impaired in iron deficiency anaemia, and it improves significantly within three days of total dose intravenous iron-dextran therapy when there is no significant increase in haemoglobin value. This is likely to represent the effect of iron at the tissue level independent of the anaemia.

Adolescent↗
PubMed1989

Bone marrow iron in nutritional anaemias.

Bone marrow smears of 168 patients with nutritional anaemias attending the Dr. J.C. Patel, Department of Hematology, K.E.M. Hospital were stained by Prussian blue method for iron (haemosiderin). Iron in the bone marrow was classified as absent, decreased, normal or increased. Amongst 93 cases with transferrin saturation (TS) of less than 16% and normoblastic erythropoiesis, bone marrow iron was absent in 48 (51.6%) and decreased in 45 (48.4%). In 50 cases with TS of less than 16% and marrow showing megaloblasts and/or giant myelocytes and metamyelocytes, bone marrow iron was absent in 15 (30%), decreased in 22 (44%), normal in 7 (14%) and increased in 6 (12%). In 25 cases with TS over 16% and megaloblastic erythropoiesis, bone marrow iron was absent in 4 (16%), decreased in 1 (4%), normal in 7 (28%) and increased in 13 (52%). In 150 (89.3%) patients out of 168, bone marrow iron and TS gave concordant results whereas in 18 (10.7%), the results were discordant; former was encountered in cases of uncomplicated iron deficiency while latter was found with megaloblastic morphology of the marrow. It is concluded that there is a good correlation between TS and bone marrow iron and hence, either of the criteria can be used for the diagnosis of iron deficiency especially when it is not complicated by megaloblastosis.

Anemia, Hypochromic↗
PubMed1989

Iron loading anaemias.

Iron loading anaemias are characterized by anaemia, high serum iron, transferrin saturation and ferritin values, and haemosiderin deposits in parenchymal cells and reticuloendothelial tissue with or without organ dysfunction. Sideroblastic anaemias and congenital dyserythropoietic anaemias (CDA) are important types of iron loading anaemias. Two cases of sideroblastic anaemia and five cases of CDA type I are presented as prototypes of iron loading anaemias. Increased gastrointestinal absorption of iron remains the main mechanism of iron loading in these anaemias. Phlebotomy can be used to reduce the iron load in those with mild or moderate anaemia, whereas desferrioxamine can be used to chelate excessive iron in all cases irrespective of severity of anaemia.

Adolescent↗
PubMed1988

Effect of iron deficiency anaemia and its treatment on the absorption and elimination of phenformin.

1. The extent of phenformin absorption and its rate of urinary excretion have been assessed in adult patients with iron deficiency anaemia, a condition which compromises gastrointestinal function. 2. Phenformin (100 mg) was administered orally to patients before treatment, three days after the start of a course of iron treatment (oral 300 mg b.d. or total intravenous iron) and at the end of 28 days, when haemoglobin was over 10 gm%. 3. No significant difference was found between mean total amounts of phenformin and 4-hydroxyphenformin excreted in urine, before treatment or after 3 or 28 days replacement therapy. It is concluded that phenformin absorption is not affected by iron deficiency. 4. In addition, iron deficiency had no significant effect on phenformin elimination half-life.

Adult↗