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B Cain

Publications and source records attributed to B Cain.

5 recordsLinked to original sources
PubMed2000

PC2 and 7B2 null mice demonstrate that PC2 is essential for normal pro-CCK processing.

Analysis of CCK content in extracts of whole forebrain from PC2 and 7B2 null mouse brain showed a significant decrease relative to wild-type brains. More detailed analysis revealed that CCK 8 amide levels in cerebral cortex and forebrain regions were more decreased than in hypothalamus. CCK 8 content in PC2 null mouse intestines was identical to control. Null mutant brains contained less CCK 8 than wild type and no other forms were seen when analyzed by gel filtration chromatography. No brain area examined was completely devoid of CCK, suggesting that other enzymes can partially compensate for the loss of PC2. This is the first demonstration that any endoprotease is important for CCK processing but also suggest the presence of a redundant system to ensure production of active CCK in the brain.

Animals↗
PubMed1998

A model of evaporation from the skin while wearing protective clothing.

A simple model was developed to describe the transport of water vapour from subjects working in hot environments while wearing chemical-protective clothing. The goal of the modelling was to obtain a better estimate of evaporative cooling of the subjects, as it was hypothesised that calculations of evaporative heat loss based on changes in dressed weight over-estimate the actual benefit experienced by the subjects. The model employed measured values of vapour pressure within the clothing ensemble to estimate the skin vapours pressure. The resistance of the clothing ensemble to water vapour transport was calculated from measurements of the physical properties of the materials in conjunction with estimates of the resistance of air layers between the clothing layers. The model predicts mean evaporation rates from the skin that are approximately 60% of those calculated from measured changes in dressed weight. Error analysis failed to account for the magnitude of this difference and possible explanations for the difference are advanced. A brief examination of the effect of wicking suggests that some of the difference results from a reduction of the resistance of the garment to water vapour due to wicking of liquid sweat through fabric layers.

Humans↗