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Biomedical subjects

B Catanese

Publications and source records attributed to B Catanese.

At least 37 records · Page 2Linked to original sources
PubMed1983

Oral absorption of bendazac lysine salt in man after repeated administrations.

The plasma levels of the lysine salt of bendazac were studied in man after repeated administrations. The substance was administered in 500 mg tablets three times daily for 21 days. Concentrations of bendazac ranging between 15 and 30 micrograms/ml were found in the plasma within 10 hours after the first administration. No significant differences were observed between the first and following days of treatment. Common laboratory and clinical tests did not show any marked change.

Administration, Oral↗
PubMed1983

Basic data supporting the use of the l-lysine salt of bendazac in cataract.

Bendazac, as such or in the form of its l-lysine salt, has a protective effect against lens protein denaturation both in vitro and in vivo. In vitro this effect has been documented on the lens proteins of rats, rabbits and pigs by using nephelometry, electrophoresis and electron microscopy. In vivo the protective effect has been observed after treatments ranging in duration from 3 to 14 days depending on the dosage used; the minimal effective dose produced a serum level of 35 micrograms/ml of bendazac. The penetration of the drug into the lens has been shown by both radioassay and HPLC; the lens concentration of bendazac increases with the duration of treatment. The mechanism of the protective action of bendazac against lens protein denaturation is discussed together with the implications of such protective action in the treatment of cataract.

Administration, Oral↗
PubMed1981

Binding of organic ions by proteins. 2. Effects of 1-benzyl-3-indazoleoxyacetate at low concentration on the oxygen affinity of human hemoglobin.

The oxygen equilibrium of human hemoglobin has been studied in the presence of 1-benzyl-3-indazoleoxyacetate (BZ). The results show that: (a) The overall oxygen affinity of hemoglobin is a function of BZ concentration, but the cooperative character of the equilibrium curve appears insensitive to the drug up to the maximal concentration studied (5 x 10(-2) M); (b) The functional expression of the interaction between hemoglobin and BZ is not affected by the presence of protons, i.e., the change in oxygen affinity determined by BZ is the same at any pH value studied; (c) The aromatic region of BZ molecules is of primary importance for the functional change of hemoglobin; (d) The difference in moles of BZ bound per mole of tetrameric unliganded and oxygenated hemoglobin corresponds to 2; these functionally relevant binding sites on the protein are probably located at alpha 1, beta 1 and alpha 2 beta 2 interfaces; (e) Thermodynamically, entropy effects dominate the reaction between hemoglobin and BZ.

Dose-Response Relationship, Drug↗
PubMed1980

Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera.

The presence in the serum of albumins having a globulin-like electrophoretic mobility (globulin-like migrating blood albumins or GLIMBAL) has been determined by immunoelectrophoresis in rat and human sera. GLIMBAL have been detected occasionally (14%) in rat sera during the acute inflammation induced by yeast injection. GLIMBAL were, on the other hand, present in pathological human sera from patients with rheumatoid arthritis (50%), systemic lupus erythematosus (69%), and liver disease (17%). These data indicate that the occurrence of GLIMBAL in human sera is more frequent than previously described. Many pathological conditions are accompanied by electrophoretic changes of serum, consisting of an increase of globulins and eventually albumin decrease; our data indicate that these changes may in some conditions reflect a process of albumin transformation rather than an increase in globulin synthesis.

Animals↗
PubMed1980

Serum levels of benzydamine following the topical use of this drug in gynecology.

The serum levels of benzydamine were studied after administration by vaginal douching (at a concentration of 0.0%) to patients with and without vaginal inflammation. In both experimental groups benzydamine produced similar serum concentrations which were lower than those obtained by other administration routes, excluding the possibillity of eventual systemic effects. These data are a further confirmation that, whenever possible, topical use is preferable to systemic use in order to reduce the incidence of systemic side effects to a minimum and to obtain a more selective therapy.

Absorption↗