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Biomedical subjects

B Cathala

Publications and source records attributed to B Cathala.

At least 37 records · Page 2Linked to original sources

Early cerebral prognosis of anoxic encephalopathy using brain energy metabolism.

Cerebral arteriovenous differences in oxygen content [C(a-v)O2] and glucose content [C(a-v)gluc] were used to predict outcome in 20 patients who remained comatose after resuscitation for cardiopulmonary arrest. Cerebral prognosis was good when C(a-v)O2 values were greater than 1.8 mMol/L and the oxygen glucose index (OGI) was greater than 85%. Our results suggest that cerebral recovery is linked with increased oxidation associated with the beginning of nonglycolytic metabolism.

Adolescent↗

[Plasma fibronectin. Role in severe infections and intensive care].

Plasma fibronectin (pFN) levels were measured in 52 patients throughout their stay in an intensive care unit. At the same time a close watch was kept for signs of sepsis. Low pFN levels regularly accompanied--but did not precede--infectious episodes and were also found in patients without septic complications. These findings indicate that a fall in pFN does not constitute a factor of increased susceptibility to infection.

Adult↗

[Increase in mean platelet volume in shock-related thrombocytopenia].

In a retrospective study the mean platelet volume (MPV) was measured in citrated plasma of 16 patients with hypovolaemic or infectious toxic shock. Bone marrow examination was carried out in most cases. Eighty p. cent of the patients had an increase in MPV, and the increase persisted even after thrombocytopenia had regressed. Cytological examination of the bone marrow failed to provide evidence that bone marrow deficiency was a predominant factor in the pathogenesis of thrombocytopenia in any of these patients. In this particular patient population, bone marrow examination should be reserved to those cases where persistent thrombocytopenia coexists with normal MPV.

Blood Platelets↗

Factor II related antigen and antithrombin III levels as indicators of liver failure in consumption coagulopathy.

In order to detect impaired synthesis of blood coagulation factors associated to consumption coagulopathy, a simultaneous evaluation of factor II-related antigen (II rAg) and of antithrombin III (AT III) was carried out in 16 patients affected with severe defibrination. An in vitro preliminary study on plasma and serum demonstrated that the levels of II rAg and of AT III, assessed by the Laurell technique with Behring antisera, were not reduced by the coagulation process. The patients were, a posteriori, classified into two groups according to the absence (group A) or the presence (group B) of factors predisposing to liver failure such as metastasis, cirrhosis, and prolonged shock. II rAg and AT III levels are significantly correlated; they are in the normal range in group A but reduced in group B. Thus II rAg or AT III level determinations are useful markers in the detection of liver failure associated to the consumption phenomenon. These results also suggest that part of the decreased AT III levels reported in severe cases of disseminated intravascular coagulation may be the consequence of an associated liver failure.

Antigens↗

[Massive blood transfusion in 50 seriously injured patients. Occurrence of pulmonary oedema (author's transl)].

This retrospective study shows correlations between the occurrence of pulmonary and massive blood transfusion in 50 seriously injured patients. They received massive transfusions on an average of 13 titers (minimum 51, maximum 30 l) including from 0 to 7,51 of macromolecular solutions (average 2,43 1). These seriously injured patients were divided into 4 groups: --20 thoracic injured patients with associated abdominal lesions, --15 thoracic injured patients without any abdominal lesions, --4 peripheral traumatism with abdominal lesions, --11 polytraumatic patients (considering only lesions of the limbs). There is a significant difference between seriously injured patients with associated abdominal lesions who were transfused and the other groups studied. Sixteen patients experienced pulmonary edema the diagnosis of which was reinforced on grounds of clinical, biological and radiological evidences. Significant difference (p:minor 0,05) were noted as regard the incidence of pulmonary edema when comparing the volume of fluids administrated to the different groups. New out of 16 patients died, mainly because of refractory hypoxia. When more than 25 liters of fluids are transfused, the prognosis is poor. Though pulmonary edema may be brought about by transfusion, other etiologic possibilities are to be investigated.

Abdominal Injuries↗

[Hemodynamic effects of dopamine, dobutamine and isoproterenol in chronic respiratory insufficiency].

A study of the effects of dopamine, dobutamine and of isoprenaline was carried out in 20 patients with chronic respiratory insufficiency, 16 of whom had pulmonary arterial hypertension (PAP: 22 mmHg). The following findings emerged: --absence of any significant effect of dobutamine on heart rate,--increase in systolic and mean PAP, after infusion of dobutamine,--increase in systolic and mean PAP, after infusion of dopamine,--decrease in BP after administration of infusion of dobutamine,--decrease in pulmonary arterial resistances under the influence of isoprenaline,--decrease in total systemic resistances after the administration of dobutamine,--increase in ventricular, systolic work after the infusion of dopamine.

Aged↗