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Biomedical subjects

B Cedergren

Publications and source records attributed to B Cedergren.

At least 55 records · Page 3Linked to original sources
PubMed1978

Serum protein and red cell enzyme polymorphisms in affective disorders.

Frequencies of serum groups (Hp and Gc) and red cell enzyme types (PGM1, 6-PGD and ES D) were studied in 195 patients with affective disorders. The patients were classified into four groups: (1) bipolar (manic-depressive) psychosis; (2) unipolar, recurrent, depressive psychosis; (3) non-psychotic reactive depression, and (4) unclassifiable. The Hp2 gene was increased in reactive and unclassifiable patients, the PGM1 1 gene was increased in bipolar patients and the ES D1 gene in reactive patients. No associations were found between affective disorders and the Gc and 6-PGD systems.

Affective Symptoms↗
PubMed1978

Blood groups and affective disorders.

Frequencies of ABO, Rh, MNSs, P, Kell, Lewis and Duffy blood groups were studied in a total of 219 patients with affective disorders. The patients were classified into four groups: (1) bipolar (manic-depressive) psychosis; (2) unipolar recurrent depressive psychosis; (3) nonpsychotic 'reactive' depression, and (4) 'unclassifiable'. The following statistically significant results were found: an increased frequency of the blood group factor B among psychotic (bipolar and unipolar) patients compared to nonpsychotic patients, a decreased frequency of the SS phenotype in the unclassifiable group and an increased frequency of the K(+) phenotype among the nonpsychotic patients. Previous results concerning differences between bipolar and unipolar patients with respect to the A and O blood types were not confirmed in this investigation.

Affective Symptoms↗
PubMed1978

HLA antigens in allergic contact dermatitis.

The relationship between HLA factors and allergic contact dermatitis was examined in a series of 149 patients with unequivocal positive reactions to one or several allergens on epicutaneous testing. Nine statistically significant associations involving 6 different HLA antigens and 6 different allergens were found. Four allergens (chromium, formalin, balsam of Peru and wool alcohol) were positively associated with the B7 antigen. Furthermore chromium allergy was associated with A3, formalin allergy with A2 (negative association) and A9, nickel allergy with B8 and colophony allergy with B27. The B7 antigen and the combination A3+B7 showed significant regressions on number of allergies. The results fit the hypothesis that some HLA factors (like B7) may predispose for multiple contact allergy and others for allergen specific reactions.

Adult↗
PubMed1977

Red cell enzyme types in psoriasis.

Seven red cell enzyme systems were examined for electrophoretic variation in a series of psoriatic patients. In two polymorphic (ADA, ES D) and four non-polymorphic systems (SOD, MDH, LDH, Dia) no deviations from normal controls were found. In the acid phosphatase system the frequency of the pa gene was found to be decreased.

Acid Phosphatase↗
PubMed1977

Genetic markers in psoriasis. Correlations to age at onset, continuity of symptoms and the risk of developing the disease.

In a study on genetic markers (22 HLA antigens, 6 blood group types, 3 serum groups and 3 red cell enzymes) in psoriatic patients the following statistically significant differences were found between patients and controls: 1) The HLA factors B13 and Bw17, the Lewis blood group Le(a-b-) and the blood group factor A were overrepresented among the patients. A decrease in the frequencies of the HLA factors B7 and B8 was noted, confirming several similar findings by other investigators. 2) In the Ss (MNSs), C3 and haptoglobin (Hp) systems the psoriatic patients showed a decreased frequency of heterozygotes. 3) Among patients with continuous symptoms the blood group factor A and the blood group Fy (a+b-) were overrepresented. 4) Patients with late onset of psoriasis showed an increase in the blood group (Fy(a+bb-) and a decrease in the haptoglobin type 2-2. Relative risk figures have been calculated for different phenotypes. Certain genetic combinations were found to be grossly overrepresented among the patients. The mechanisms behind the associations appear to differ. In three systems (Ss, C3 and Hp) the deviations in psoriatic patients suggest the presence of heterozygote advantage.

Adolescent↗
PubMed1977

Increased serum levels of the pregnancy zone protein in psoriasis.

On the basis of immunological studies on psoriasis in recent years, it seems probable that immunological mechanisms are of importance and that psoriasis could be regarded as an immunogenetic disease. In this study, increased serum levels of an immunosuppressive factor, the pregnancy zone protein (PZ), were found in psoriatic patients. Patients with elevated levels (greater than 2 S.D. units) of PZ showed a positive association with continuous symptoms and a negative association with blood groups A and Fy(a+b-). Thus, induction of PZ occurs mainly in psoriatic patients who have a particular genetic constitution. The results support the hypothesis that PZ is not only an immunosuppressive but also an immunoreactive protein.

Adolescent↗
PubMed1976

The Vel blood group in northern Sweden.

Using the potent anti-Vel, Paul., a detailed study of the Vel blood group has been made in the Northern region of Sweden. Family studies have shown Vel to be independent of P1, though some association with P groups was detected since P2 was more frequent amongst Vel(-) than expected. The frequency of Vel(-) was 0.0006.

Blood Group Antigens↗