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Biomedical subjects

B Chattopadhyay

Publications and source records attributed to B Chattopadhyay.

At least 19 recordsLinked to original sources
PubMed1992

Pseudobacteraemia with multiply-resistant Klebsiella pneumoniae resulting from contamination from the blood gas machine on a neonatal unit.

Klebsiella pneumoniae with an unusual antibiotic susceptibility pattern was isolated from blood cultures of seven unwell premature babies on the Special Care Baby Unit. Although the organism was sensitive to cefuroxime it was resistant to ceftazidime. It was also resistant to gentamicin, tobramycin, netilmicin, piperacillin and aztreonam but sensitive to ciprofloxacin, imipenem and amikacin. On extensive investigation to trace the source, a K. pneumoniae with the same susceptibility pattern as that obtained from blood cultures was isolated from the probe and probe cover on the blood gas machine but not from any other environmental samples or clinical specimens. Where clinically indicated, antibiotics were used to treat these babies, with success. The difficulty, however, of differentiating between true septicaemia and pseudobacteraemia could be enormous as withholding treatment will have disastrous consequences in genuine cases of bacteraemia.

Bacteremia↗
PubMed1991

Postoperative endophthalmitis.

Postoperative endophthalmitis is a rare complication of ophthalmic surgery. The use of prophylactic antibiotics and scrupulous surgical techniques will help to reduce its incidence, but sporadic cases may still occur. If postoperative endophthalmitis is a diagnostic possibility aggressive investigation and initial management improves the prognosis. More work needs to be done to evaluate the penetration of newer antibiotics into the eye and their therapeutic role. The use of corticosteroids also needs to be more carefully defined in the treatment of this potentially devastating disease.

Coagulase↗
PubMed1979

In vitro combination of mecillinam with cephradine or amoxycillin for organisms resistant to single agents.

Of 36 multi-resistant Gram-negative bacilli isolated from different cases of urinary tract infection, 18 strains of Escherichia coli, klebsiella, enterobacter, proteus, providencia and serratia with the exception of Acinetobacter species showed synergy when mecillinam was combined with cephradine or amoxycillin in the ratio of 1:1. Combination with cephradine was synergistic on sixteen occasions and amoxycillin on six. Synergy, which might have clinical relevance, was demonstrated only when the test organism was either fully or moderately sensitive to one of the two antibiotics combined but not when resistant to both.

Amdinocillin↗
PubMed1978

Human milk bank in a district general hospital.

A human milk bank was organised in the special care baby unit of a district general hospital. The staff of the unit and members of a voluntary organisation helped to contact donors and arrange collection of milk samples. Over two years 2093 samples of expressed breast milk were collected from 187 donors and examined bacteriologically. Of these samples, 1171 (56%) grew no bacteria. If the organism count exceeded 2.5 X 10(6)/1 but was less than 1 X 10(9)/1 samples were subjected to mild heat treatment. If the count exceeded 1 X 10(9)/1 the milk was not fed to babies. Sixty-five babies received milk from the bank during the second year. Although these infants were vulnerable, mortality and morbidity were not adversely affected by the banked milk they received. The cost of establishing and running a human milk bank need not be high. Extensive resources such as extra staff and laboratory and transport facilities were not needed. Enthusiastic co-operation and good will between hospital staff, voluntary helpers, and donors contributed greatly to the success of the scheme.

Costs and Cost Analysis↗
PubMed1977

Noxythiolln-resistant organisms in a district general hospital.

Twelve strains of Pseudomonas aeruginosa, three strains of Klebsiella aerogenes, and two strains of Escherichia coli were found to be resistant to noxythiolin. Some of the pseudomonads were isolated from patients in the same ward, not all of whom were on noxythiolin treatment. The strains from these patients were indistinguishable from each other on phage typing, which suggested cross-contamination. No Gram-positive organism was found to be resistant to noxythiolin. Noxythiolin should not be used before a disc diffusion sensitivity test has been performed to determine whether the organisms are sensitive to it. This is particularly important when pseudomonads are the offending organisms.

Cross Infection↗
PubMed1977

Giardiasis.

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Adolescent↗