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Biomedical subjects

B Choudhury

Publications and source records attributed to B Choudhury.

14 recordsLinked to original sources

Treatment of aneurysmal bone cysts with percutaneous sclerotherapy using polidocanol. A review of 72 cases with long-term follow-up.

Aneurysmal bone cyst is a rare tumour-like lesion which develops during growth. Our aim was to determine the efficacy of the administration of percutaneous intralesional 3% polidocanol (hydroxypolyaethoxydodecan) as sclerotherapy. Between July 1997 and December 2004 we treated 72 patients (46 males, 26 females) with a histologically-proven diagnosis of aneurysmal bone cyst, at various skeletal sites using this method. The sclerotherapy was performed under fluoroscopic guidance and general anaesthesia or sedation and local anaesthesia. The mean follow-up period was 34 months (26.5 to 80). The patients were evaluated using the Enneking system for functional assessment and all the lesions were radiologically quantified into four grades. The mean age of patients was 15.6 years (3 to 38) and the mean number of injections was three (1 to 5). Ten patients were cured by a single injection. The mean reduction in size of the lesion (radiological healing) was found to be 76.6% (61.9% to 93.2%) with a mean clinical response of 84.5% (73.4% to 100%). Recurrence was seen in two patients (2.8%) within two years of treatment and both were treated successfully by further sclerotherapy. Percutaneous sclerotherapy with polidocanol is a safe alternative to conventional surgery for the treatment of an aneurysmal bone cyst. It can be used at surgically-inaccessible sites and treatment can be performed on an out-patient basis.

Adolescent↗

Biobleaching of nonwoody pulps using xylanase of Bacillus brevis BISR-062.

The efficiency of xylanase of Bacillus brevis BISR-062 as a prebleaching agent was evaluated on three nonwoody pulps at two different pH values (7.0 and 8.5). Crude xylanase was found to have an optimum temperature and pH of 65-70 degrees C and 7.0, respectively. The stability of the enzyme was determined at two pH values (7.0 and 8.0), and it lost approx 50% of its activity at both values within 2 h at 50 degrees C. However, the enzyme was found to be effective as a prebleaching agent only with rice straw pulp. A maximum brightness gain of 6 points was obtained with this pulp at pH 7.0. The strength properties of the rice straw pulp at pH 7.0 also improved as the result of enzyme treatment.

Bacillus↗

Lactic acid fermentation in cell-recycle membrane bioreactor.

Traditional lactic acid fermentation suffers from low productivity and low product purity. Cell-recycle fermentation has become one of the methods to obtain high cell density, which results in higher productivity. Lactic acid fermentation was investigated in a cell-recycle membrane bioreactor at higher substrate concentrations of 100 and 120 g/dm3. A maximum cell density of 145 g/dm3 and a maximum productivity of 34 g/(dm3.h) were achieved in cell-recycle fermentation. In spite of complete consumption of substrate, there was a continuous increase in cell density in cell-recycle fermentation. Control of cell density in cell-recycle fermentation was attempted by cell bleeding and reduction in yeast extract concentration.

Biomass↗

Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core.

In response to the in vivo environment, the Salmonella enterica serovar Typhimurium lipopolysaccharide (LPS) is modified. These modifications are controlled in part by the two-component regulatory system PmrA-PmrB, with the addition of 4-aminoarabinose (Ara4N) to the lipid A and phosphoethanolamine (pEtN) to the lipid A and core. Here we demonstrate that the PmrA-regulated STM4118 (cptA) gene is necessary for the addition of pEtN to the LPS core. pmrC, a PmrA-regulated gene necessary for the addition of pEtN to lipid A, did not affect core pEtN addition. Although imparting a similar surface charge modification as Ara4N, which greatly affects polymyxin B resistance and murine virulence, neither pmrC nor cptA plays a dramatic role in antimicrobial peptide resistance in vitro or virulence in the mouse model. Therefore, factors other than surface charge/electrostatic interaction contribute to resistance to antimicrobial peptides such as polymyxin B.

Animals↗

Azocarbazole Polymethacrylates as Single-Component Electrooptic Materials.

A series of amorphous azobenzene and carbazole-containing polymers was prepared, which incorporates both electrooptic activity and photoconductivity into a single multifunctional structural unit. The polymers were cast as thin films and were shown to be suitable for photoinducing birefringence reversibly with polarized light, as well as for the inscription of photorefractive diffraction gratings after electric field poling. Since the polymer series encompasses a range of spacer lengths (from 3 to 10 methylene groups) between the multifunctional side chains and the polymer backbone, these materials are suitable for study of the influence of chromophore mobility on these optical phenomena. The extent of orientational order which could be photoinduced in the films was found to decrease with increasing spacer length, as did the photoconductivity and the photorefractive two-beam optical coupling gain. In thin films of polymers with the highest glass transition temperature, a birefringence of 0.065 could be photoinduced, with a time constant of <0.8 s. A two-beam optical gain of 0.024 µm-1 was also demonstrated in films of the polymer with the highest glass transition temperature, although this gain was exceeded by absorption losses.

Journal Article↗

Susceptibility of Plasmodium falciparum to chloroquine in tea garden tribes of Assam, India.

P. falciparum was the predominant parasite ( > 80%) species in malaria ridden tea estates of Assam. A simplified 3 day in vivo test to determine chloroquine sensitivity in tea garden tribes revealed that the majority of the cases (85%) were S/RI, 7% were RI, and 3% were RII and 5% were RIII, respectively. Early case detection and treatment were deemed necessary to reduce morbidity and mortality due to P. falciparum in these tea estates.

Adolescent↗

Foot and mouth disease in gayals (Bos gaurus frontalis) in Calcutta Zoo.

A brief description is given of an outbreak of foot and mouth disease in gayals (Bos gaurus frontalis) which occurred in Calcutta Zoo in October 1990. Four of the five affected animals died within ten days of onset of the disease. The disease did not spread to other animals in the Zoo.

Animals↗

Age changes in some somatometric characters of the Assamese Muslims of Kamrup district, Assam.

Growth in weight, stature, sitting height, lower extremity length, head circumference and girth of biceps, chest and calf were studied in a cross-sectional sample of Assamese Muslims in Kamrup district, Assam, India. The sample comprised 835 boys and 894 girls, aged 3-20 years. The average growth pattern for the linear body dimensions was analysed by fitting Preece Baines model I to the mean values. The other dimensions were analysed in terms of simple line charts. Average final size and age at peak velocity of the linear dimensions were derived from the fitted curves. The data for height and weight were compared with other samples of the same district, with national urban and rural growth data for India, and with the NCHS growth standards. Mean height and weight of Assamese Muslim children fluctuates between the 5th and 10th centile of the NCHS standards up to approximately 15 years in boys and 13 years in girls. Thereafter, average length and weight lags behind the American standards, ending up below the 5th centile. The differences between the growth of Assamese Muslims and other populations are discussed.

Adolescent↗

Environmental effects on morphine content in opium poppy (Papaver somniferum L.).

Ten cultivars of opium poppy were tested for morphine content during the past five years at the Indian Agricultural Research Institute (IARI), New Delhi. Techniques employed to determine the adaptive potential (Finlay and Wilkinson, 1963; Eberhart and Russel, 1966), relative stability and environmental interaction showed the significant varietal differences when the cultivars' mean square was tested over pooled deviations as the error term. Significant V- X -E (linear) component suggests the existence of genetically conditional differences in the stability of cultivars. Highest morphine content was observed in cultivar H and least in R. Four cultivars exceeded the grand mean. Within the five-year study period three were observed to have given the highest morphine content.

Drug Stability↗